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D5_Yogie_Irawan.pptx
- 1. Yogie Irawan, Harsini,Yusup Subagio Sutanto PULMONOLOGY AND RESPIRATORY MEDICINE DEPARTMENT OF SEBELAS MARET UNIVERSITY MEDICAL FACULTY /Dr. MOEWARDI GENERAL HOSPITAL SURAKARTA 2023 DIFFERENCES IN INTERLEUKIN-6 AND NEUTROPHIL LEVELS IN PNEUMONIA PATIENTS WITH AND WITHOUT GARLIC (ALLIUM SATIVUM) SUPPLEMENTATION
- 2. Introduction Pneumonia is anacute lung inflammation caused by various microorganisms such as bacteria, viruses, fungi, or parasites. Uncontrolled and excessive inflammation in pneumonia patient causes higher mortality and morbidity rates. Garlic and its organosulfur content possess anti-inflammatory activity that has the potential to be used as additional therapy in pneumonia patients. The examination of IL-6 and neutrophils helps in diagnosis, used as a marker of inflammation, predictor of mortality and morbidity, and useful in evaluating the outcome of treatment.
- 3. Method Clinical study withpretest-posttest quasi-experimental design was conducted on pneumonia patients who were hospitalized at RSUD Dr. Moewardi Surakarta from August – October 2022 by consecutive sampling. The treatment group (n=20) received standard therapy plus 3.5 mg garlic capsules per day for 6 days while the control group (n=20) received standard therapy. IL-6 and neutrophil levels were calculated on the first and sixth days.
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- 5. Result Basic Characteristics Subjects p Value StudyControl Gender 0.525 Female 10 (50.0%) 8 (40.0%) Male 10 (50.0%) 12 (60.0%) Age 55.90 ± 13.92 57.50 ± 16.85 0.378 PORT PSI Score 81.50 ± 19.42 82.70 ± 12.85 0.819 Occupation 0.78 Housewife 6 (30.0%) 8 (40.0%) Seller Driver Student Construction laborer Employees Farmer Retired Unemployed 3 (15.0%) 1 (5.0%) 1 (5.0%) 0 (0.0%) 0 (0.0%) 2 (10.0%) 2 (10.0%) 5 (25.0%) 3 (15.0%) 1 (5.0%) 1 (5.0%) 1 (5.0%) 1 (5.0%) 2 (10.0%) 0 (0.0%) 3 (15.0%) Smoking history 0.519 Negative 11 (55.0%) 13 (65.0%) Positive 9 (45.0%) 7 (35.0%) Table 1. Basic Characteristics of Research Subjects
- 6. Result Table 2.IL-6 Level Before and After Medication Subjects IL-6 p Value IL-6 Difference Pretest Posttest Study 146.69 ± 151.63 53.11 ± 58.14 0.003 -93.58 ± 128.64 Control 97.05 ± 156.37 67.14 ± 78.0 0.881 -29.91 ± 173.42 p Value 0.234 0.665 0,027
- 7. Result Table 3.Neutrophil Level Before and After Medication Subjects Neutrophil p Value Neutrophil Difference Pretest Posttest Study 13525.90 ± 5210.53 9647.00 ± 3914.68 <0.001 -3878.90 ± 3271.79 Control 11858.90 ± 7520.05 10045.25 ± 3815.19 0.191 -1813.65 ± 4527.84 p Value 0.123 0.746 0.025
- 8. Discussion High levels ofIL-6 in patients indicate ongoing inflammation and are associated with clinical symptoms and severity of pneumonia. Arreola et al. 2015: the organosulfur content of garlic provides an immunoregulatory effect and affects immune cells thereby reducing IL-6 levels Shang et al. 2019: garlic can inhibit inflammation by inhibiting inflammatory mediators such as IL-6, TNF-α, and IL-1 so that it has good potential as a therapy for inflammatory diseases.
- 9. Discussion Neutrophils can produceROS and RNS to kill pathogens, but these toxic molecules can also damage tissues if their release is excessive. Alam et al. 2018: Administration of organosulfur content from garlic significantly reduced neutrophil levels with p<0.05 in the treatment group, and also reduced IL-6 levels. Schepetkin et al. 2019: Garlic's organosulfur content suppresses ROS production by neutrophils, and is an effective therapeutic modulator of innate immune response.
- 10. Conclusion There was asignificant IL-6 levels decrease in subjects who received garlic. There was a significant neutrophil levels decrease in subjects who received garlic. 1. 2.
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