The document discusses recent advances in the understanding of facial aging. It notes that volume loss, including of soft tissue and bone, is as or more important than gravity in facial aging. Recent work has demonstrated that techniques focusing on restoring lost volume through procedures like fat grafting have produced outstanding rejuvenation results. This reflects an increased emphasis on volume restoration to address facial aging.
Dr Patrick Treacy explains how the use of a combination of
restorative dermal techniques allowed him to address the
poor skin texture and facial sagging in a patient with cancer
related cachexia
Patrick Treacy explains how the use of a combination of restorative dermal techniques allowed him to address the poor skin texture and facial sagging in a patient with cancer related cachexia
Calcium Hydroxylapatite Over a Decade of Clinical Experiencekpyu
Background: Calcium hydroxylapatite is one of the most well-studied dermal fillers worldwide and has been
extensively used for the correction of moderate-to-severe facial lines and folds and to replenish lost volume.
Pink bands in a criss- cross pattern on a ten- nis player’s shoulder, blue strips surrounding a cy- clist’s knee, a red streak along a hurdler’s Achilles tendon: clearly athletes, Olympic and otherwise, subscribe to the use of elastic therapeutic, or kinesiology, tape. But is this a fashion statement or does kinesiology tape have a real function?
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative O...Mark Babizhayev
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative Oral Dosage Forms of Non-Hydrolized Carnosine and Carcinine. Int J Clin Dermatol Res. 5(5), 116-143.
The Evolution of Kinesiology Tape...more than pretty colours?RockTape
Cross-crossing pink bands across a tennis player’s shoulder, blue strips surrounding a cyclist’s knee, and a red streak along a hurdler’s Achilles tendon. Clearly athletes, Olympic and otherwise, subscribe to the use of elastic therapeutic or kinesiology tape. But is this a fashion statement or does kinesiology tape have a real function?
The DUBLiN Lift: To establish the clinical effectiveness of combining five treatments in the rejuvenation of the ageing face in an effort to increase aesthetic effect, patient safety, and reduce laser downtime.
Dr Patrick Treacy explains how the use of a combination of
restorative dermal techniques allowed him to address the
poor skin texture and facial sagging in a patient with cancer
related cachexia
Patrick Treacy explains how the use of a combination of restorative dermal techniques allowed him to address the poor skin texture and facial sagging in a patient with cancer related cachexia
Calcium Hydroxylapatite Over a Decade of Clinical Experiencekpyu
Background: Calcium hydroxylapatite is one of the most well-studied dermal fillers worldwide and has been
extensively used for the correction of moderate-to-severe facial lines and folds and to replenish lost volume.
Pink bands in a criss- cross pattern on a ten- nis player’s shoulder, blue strips surrounding a cy- clist’s knee, a red streak along a hurdler’s Achilles tendon: clearly athletes, Olympic and otherwise, subscribe to the use of elastic therapeutic, or kinesiology, tape. But is this a fashion statement or does kinesiology tape have a real function?
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative O...Mark Babizhayev
Babizhayev MA (2017) Treatment of Skin Aging and Photoaging with Innovative Oral Dosage Forms of Non-Hydrolized Carnosine and Carcinine. Int J Clin Dermatol Res. 5(5), 116-143.
The Evolution of Kinesiology Tape...more than pretty colours?RockTape
Cross-crossing pink bands across a tennis player’s shoulder, blue strips surrounding a cyclist’s knee, and a red streak along a hurdler’s Achilles tendon. Clearly athletes, Olympic and otherwise, subscribe to the use of elastic therapeutic or kinesiology tape. But is this a fashion statement or does kinesiology tape have a real function?
The DUBLiN Lift: To establish the clinical effectiveness of combining five treatments in the rejuvenation of the ageing face in an effort to increase aesthetic effect, patient safety, and reduce laser downtime.
Best facial cosmetic surgeons Best facial plastic surgeon Browlift Charlotte endoscopic brow lift Charlotte’s top facial plastic surgeon Facial plastic surgeons Facial plastic surgery Face lifts Facial mini-tuck Lip enhancement Lip augmentation Nose job Nose job cost Nose surgery Rhinoplasty Rhinoplasty Expert Rhinoplasty and teens Revision rhinoplasty Teen Rhinoplasty, Charlotte Teen Rhinoplasty, North Carolina Teen Rhinoplasty Expert Top rhinoplasty surgeons Best Charlotte rhinoplasty surgeons Most experienced rhinoplasty surgeons
Nano-composite scaffolds based on electrospun nanofibers have gained great attention due to their ability to emulate natural extracellular matrix (ECM) that affects cell survival, attachment and reorganization.
Promoted protein absorption, cellular reactions, activation of specific gene expression and intracellular signaling, and high surface area to volume ratio are also important properties of nanofibrous scaffolds.
Moreover, several bioactive components, such as bioceramics and functional polymers can be easily blended into nanofibrous matrixes to regulate the physical-chemical-biological properties and regeneration abilities.
Simultaneously, functional growth factors, proteins and drugs are also incorporated to regulate cellular reactions and even modify the local inflammatory microenvironment, which benefit periodontal regeneration and functional restoration
Nano-composite scaffolds based on electrospun nanofibers have gained great attention due to their ability to emulate natural extracellular matrix (ECM) that affects cell survival, attachment and reorganization.
Promoted protein absorption, cellular reactions, activation of specific gene expression and intracellular signaling, and high surface area to volume ratio are also important properties of nanofibrous scaffolds.
Moreover, several bioactive components, such as bioceramics and functional polymers can be easily blended into nanofibrous matrixes to regulate the physical-chemical-biological properties and regeneration abilities.
Simultaneously, functional growth factors, proteins and drugs are also incorporated to regulate cellular reactions and even modify the local inflammatory microenvironment, which benefit periodontal regeneration and functional restoration
Current opinion-article-volume-loss-versus-gravity
1. Volume loss versus gravity: new concepts in facial aging
Alexander S. Donath, Robert A. Glasgold and Mark J. Glasgold
Purpose of review
The earliest techniques of facial rejuvenation have been
continuously adapted to reflect changes in the
understanding of the aging face. Significant,
paradigm-shifting advances in this understanding have
been made in recent years which have allowed application
of specific therapeutic modalities, resulting in dramatically
improved results over those achieved with traditional facial
rejuvenation.
Recent findings
Pioneering work by several authors has shown that gravity is
not the sole determinant of the aging face. These authors
have demonstrated that volume loss, including that of soft
tissue and bone, is at least equally important in the
pathogenesis of the stigmata of aging. Rejuvenative
techniques developed to reverse these atrophic changes
have exhibited outstanding results. The consequence is an
increasing emphasis on the use of volume restoration
procedures to address the aging face.
Summary
Recent improvements in the understanding of the facial
aging process have brought about newly refined techniques
for facial rejuvenation, ushering in a new era of plastic
surgery for the aging face which is being manifested by
increasingly natural results.
Keywords
autologous fat grafting, gravity, lipoatrophy, volume loss
Curr Opin Otolaryngol Head Neck Surg 15:238–243. ß 2007 Lippincott Williams &
Wilkins.
Glasgold Group Plastic Surgery, Highland Park, New Jersey, USA
Correspondence to Alexander S. Donath, MD, Glasgold Group Plastic Surgery,
31 River Road, Highland Park, NJ 08904, USA
Tel: +1 732 846 6540; fax: +1 732 846 8231; e-mail: a_donath@yahoo.com
Current Opinion in Otolaryngology & Head and Neck Surgery 2007,
15:238–243
ß 2007 Lippincott Williams & Wilkins
1068-9508
Introduction
The recent years have born witness to some of the most
exciting advances in the field of facial plastic surgery in
modern times. The relentless quest for the ideal reversal
of the stigmata of aging has led to observations which
have challenged, and indeed largely overturned,
traditional tenets of aging face theory. Armed with these
observations, pioneers in the field have developed and
honed novel, imaginative techniques in an attempt to
provide the most natural rejuvenation ever achieved.
Following a review of the current concepts in the aging
face, including its bony foundation, muscular structure,
ligamentous support, and skin, we focus on the changes in
subcutaneous tissue with age. An overview of volume
restoration is then presented, and we conclude with the
approach now utilized in our practice – complementary
use of volume restoration with more traditional pro-
cedures [1
] – and discuss how this approach reflects
recent changes in understanding of facial aging.
Bone
Intriguing work has been put forth by Pessa and col-
leagues [2,3], which implicates a contribution of bony
remodeling in the pathogenesis of the aging face. Using
computed tomography, these studies demonstrated a
posterior–inferior rotation of the facial skeleton toward
the cranial base with age. This posterior remodeling is
thought to further undermine midfacial support and
projection, including that of the inferior orbital rim,
and to contribute, therefore, to malposition of the lower
eyelid with lateral bowing and scleral show.
In addition to the generalized bony remodeling described
by Pessa et al., a particular area of bony atrophy which has
been previously described by Mittleman [4] is the
anterior mandibular groove. This area lies between the
mentum and the body of the mandible, just anterior to
the soft tissue of the jowl region. The corresponding soft
tissue depression over the anterior mandibular groove has
thus been termed the prejowl sulcus. Soft tissue atrophy
occurs in the prejowl sulcus as well, exacerbating the
depression caused by bony atrophy; neither is addressed
by traditional facelifting techniques.
Muscle
Pervasive in the literature is the concept that muscle
undergoes relaxation with aging. The orbicularis oculi
and zygomaticus muscles have been among the most
frequently cited, being credited in the past with roles in
descent of the midface and having procedures developed
238
2. warranted to further elucidate the relative role of colloidal
fluid loss in cutaneous aging.
Volume restoration
While the degree to which specific structures outlined
above undergo atrophy in the face remains the subject of
some debate, what has become increasingly clear is that
volume loss plays a pivotal role in the development of
stigmata of the aging face [1
,6,29,30
,31
,32]. No longer
is there a domination of the dogma that the primary event
is a gravity-induced sagging of all facial structures.
Indeed, it is our position that gravity does nothing more
than determine the direction in which the atrophic,
deflated soft tissues hang. The effect is exaggerated by
the lengthening of the skin envelope, secondary to the
histologic changes outlined above. With this appreci-
ation, the surgeon is able to choose from an increasing
number of materials for soft tissue augmentation, both
temporary and permanent [1
,29,31
,33].
Autologous fat grafting
Fat grafting has been used successfully for soft tissue
augmentation since 1893 [34]. The early experiences,
however, were such that, while fat produced more
natural results than other available fillers [35], the long-
evity of the graft was disappointing. Even as recently as
the late 1980s and early 1990s, well respected plastic
surgeons were publicly denouncing fat transfer through
injection [36–39]. Fortunately, with additional experi-
ence they adjusted their technique and obtained more
encouraging results [40,41]. Surgeons have now been
able to demonstrate qualitatively that fat grafting can
create not only excellent changes in contour, but also
long-lasting results [41–44]. There is, however, a
relative paucity of quantitative data to support these
findings. As a result, our group is currently evaluating the
long-term volumetric changes in the face quantitatively
with three-dimensional imaging analysis (Vectra 3D
Imaging System; Canfield Imaging Systems, Fairfield,
New Jersey, USA). Much of the credit for the improved
success and longevity of autologous fat belongs to Cole-
man, who has encouraged atraumatic handling and
methodical layering of the material to improve surviva-
bility [33,42,45
,46–49]. Current applications include
not only cosmetic facial enhancements, but also trau-
matic deformities, hemifacial atrophy, HIV-associated
lipodystrophy, postliposuction irregularities, and others
[50].
In the senior authors’ practice, fat transfer has been
utilized for facial rejuvenation with very satisfying cos-
metic results and longevity for the past 10 years, with
minimal complications [1
]. Primary areas of treatment
include the infraorbital region, anterior and lateral
cheek, brow and upper eyelid, prejowl sulcus, and man-
dibular angle (Fig. 1). The use of fat grafting in these
areas, in a complementary fashion with facelifting and
blepharoplasty, has afforded rejuvenative results pre-
viously unattainable with standard techniques.
In addition to the outstanding results of lipotransfer for
volume restoration, surgeons have become increasingly
interested in the apparent rejuvenative effects on the
skin itself. Coleman [45
] has noted improved skin
quality, with softening of wrinkles, decreased pore size,
and improved pigmentation during the first year post-
treatment. Topographical skin analysis systems such as
the recently developed VISIA system (Canfield Imaging
Systems) may determine whether the effect from fat
grafting is an effective skin rejuvenation technique in
comparison to chemical peels and laser resurfacing. Aside
from effects on normal, aged skin, when fat has been
grafted beneath depressed scars there was improvement
not only in the depression, but also in the character of
the scar itself, with an apparent transformation to normal-
appearing skin [33]. Other authors have reported a
diverse range of improvements in soft tissue conditions,
including radiation damage, breast capsular contracture,
damaged vocal cords, and chronic ulceration, as well as
regrowth of calvarial bone [51–55]. While many of
the exact mechanisms for these effects remain to be
described, what seems to be at the center of these
changes is the presence of stem cells in human adipose
tissue. This has proven the most abundant source of
stem cells in the body [56–57], and the coming years
will undoubtedly yield further applications as our under-
standing improves.
240 Facial plastic surgery
Figure 1 Pre- (left) and 4-year postoperative (right) images of a
56-year-old patient who underwent autologous fat grafting to
the inferior orbital rims, cheeks, buccal regions, and prejowl
sulci
A deep-plane facelift was performed 2 years following fat transfer to
enhance the rejuvenative effect. Readily apparent is the volume restor-
ation in the midface and jawline. Reproduced with permission from
Lam et al. [1
].