Cryoglobulinemia- Basic Introduction,symptoms,types,diagnosis and treatment.

1. Made by:-Md.Neyaz Khan
1712101048
B.P.T.(2nd Year)
Galgotias University

2.  An abnormal protein present in the blood.
Form precipitate at low temp.(0-4 deg.)
Dissolve again when blood is heated.
Clump & Blocking blood vessels.
caused local ischaemia.
(toes & fingers become gangrenous)

4. 1. Skin lesion:-develops purplish or
reddish skin lesions on legs & hands.
2. Joint pain:-R.A are more common.
3. Peripheral neuropathy:- can damaged
the nerves causing numbness and
other problems.

5.  Classified into 3 groups based on Ig & rheumatoid
factor activity.
Type 1- is a monoclonal antibody that
doesn’t have rheumatoid factor activity.
eg:-Lymphoma
Type 2- is monoclonal that have
presence of rheumatoid factor.
Type 3- is polyclonal antibody with
rheumatoid factor.

6.  Type 2 & type 3 are Mixed with both IgG, & IgM.
 Most commonly with recurrent lower extremities
purpura, glomerulonephritis, & peripheral
neuropathy.

7.  Rheumatoid factor is a sensitive test for
cryoglobulinemia.
 Other routine tests include measuring blood levels
of rheumatoid factor activity, complement C4, other
complement components, and hepatitic C antigen.
 Biopsies of skin lesions and, where indicated, kidney
or other tissues can help in determining the nature
of the vascular disease.

8.  Advice to avoid or protect their extremities from
exposure to Cold.
 Drug used are prime risk factor because more than
90% of cases are associated with hepatitis C
infection.
 Prednisone, cylcophosphoamide should be
administered.