1) St. Vincent de Paul made multiple attempts over several decades to establish a Catholic mission on the island of Madagascar, but faced many hardships as most missionaries died soon after arriving. 2) Despite the deaths of the missionaries, St. Vincent recognized God's call for the Vincentians to evangelize in Madagascar and continued sending missionaries there, believing their efforts would help establish God's kingdom for the people of Madagascar. 3) St. Vincent provided guidance and support to the missionaries through letters, but also acknowledged the incomprehensibility of God's plans when the missionaries faced difficulties and death. He maintained the mission was God's will despite the challenges.