This document discusses strategies for handling complex workers' compensation exposure claims that involve multiple injuries, illnesses, physicians, employers or exposures. It outlines steps to take such as investigating prior medical and employment history, conducting an employer and exposure investigation, determining when to obtain an independent medical examination, evaluating the IME results, and deciding whether to accept or deny the claim. The document also covers considerations for vocational rehabilitation, claim closure outcomes, and provides final thoughts around thoroughly reviewing medical records and legal issues.