Coagulase-negative Staphylococcus aureus includes Staphylococcus epidermidis and Staphylococcus saprophyticus, both characterized as gram-positive cocci in clusters that are catalase positive and coagulase negative. They do not ferment mannitol and can be differentiated by novobiocin sensitivity, with S. saprophyticus being resistant. S. epidermidis is known to cause pyogenic infections related to prosthetic implants, while S. saprophyticus is associated with urinary tract infections.

1. Coagulase negative
staphylococcus aureus
CONS

2. 1. Staphylococcus epidermidis
2. Staphylococcus saprophyticus

3. Characteristics
• Gram positive cocci in clusters
• Catalase positive
• Coagulase negative
• Non hemolytic on blood agar
• Do not ferment mannitol
• They are differentiated by novobiocin sensitivity
-s. saprophyticus is novobiocin resistant

9. • S. epidermidis cause pyogenic infections especially in
prosthetic implant materials
• S. saprophyticus cause pyogenic infections of the urinary
tract infection