Clinical research has evolved from traditional in-person trials (1.0) to virtual and hybrid trials (2.0), enabling patients to participate remotely through electronic forms and wearables, significantly improving data quality and patient compliance. This transition eliminates geographical limitations, allows convenient scheduling, and enhances the collection of diverse data points from multiple sources. Real-world examples demonstrate that technology in clinical trials can nearly double diagnosis rates for conditions like atrial fibrillation.

1. CLINICAL RESEARCH — 1.0
Paperwork (Consent, PRO/COA, Diaries,
additional forms, etc.)
Limited geographical location
Patients have to visit a hospital or site, in-
person
Data collection is inconsistent and incomplete
The Evolution of Clinical Trials
www.delvehealth.com

2. CLINICAL RESEARCH — 2.0
Electronic Forms (eConsent, ePRO/eCOA,
eDiaries, etc.)
No geographical limitations
Patients can schedule virtual visits, at their
convenience
Data collection is seamless and automatic via
wearables & biosensors
The Evolution of Clinical Trials
www.delvehealth.com

3. Increases the quality of the data
Improves long-term data collection (i.e., after 30
days, data compliance drops to around 30%)
Increases patient diversity
Increases patient compliance and retention, as it
is less time consuming for a patient to participate
www.delvehealth.com
The Benefits of Virtual and
Hybrid Clinical Trials

4. www.delvehealth.com
The Benefits of Virtual and Hybrid Clinical Trials
Data from
Wearables
Data from
Physicians
Data from
Hospitals
Data from
Imaging
Data from
In-Home Nurses
Data from
Mobile Phones

5. www.delvehealth.com
The Benefits of Virtual and Hybrid Clinical Trials
Data from
Wearables
Data from
Physicians
Data from
Hospitals
Data from
Imaging
Data from
In-Home Nurses
Data from
Mobile Phones
Single
Technology
Platform

6. A single platform and central repository
increases the quality of data outcomes
Multiple data points from a diverse set of
patient participants increases the data
quality overall
Multiple data points collected automatically
from patients allows for disease-specific
analytics, unique to your specific study
www.delvehealth.com
The Benefits of Virtual and
Hybrid Clinical Trials

7. Clinical Trials 1.0—A patient had to come into the
hospital to test how far they could walk, and the
resulting analysis could take a few days
Clinical Trials 2.0—A patient can now test via
wearable or smartphone and more accurate data
is automatically calculated and reported
www.delvehealth.com
Real World Examples of Benefits
Example 1: The Six-Minute Walk
Example 2: eBRAVE_AF Trial
Primary efficacy endpoint, newly diagnosed AF
within six (6) months nearly doubles with use of
technology
Clinical Trials 1.0—0.63% diagnosis rate
Clinical Trials 2.0—1.33% diagnosis rate