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A	
  video-­‐based	
  educa.onal	
  tool	
  to	
  
increase	
  HPV	
  vaccine	
  series	
  
ini.a.on	
  among	
  adolescents:	
  
does	
  mode	
  of	
  delivery	
  ma;er?
Yasmeen Wermers
Dr. Kristen Feemster MD
Developed with collaboration with Noble Medical LLC
What	
  is	
  
HPV?
HPV
-­‐ STI	
  (sexually	
  transmi;ed	
  Infec.on)	
  	
  
-­‐ sexual	
  contact	
  	
  
-­‐ vaginal,	
  anal,	
  or	
  oral	
  sex
(Human Papillomavirus)
HPV Leads to Cancer
Cervical	
  Cancer	
   	
  Penile	
  Cancer
Anal	
  Cancer	
  
Genital	
  warts	
  	
  
http://www.cdc.gov/cancer/hpv/
Hard	
  to	
  detect	
  
-­‐ Many	
  get	
  infected	
  with	
  HPV	
  
-­‐ Stays	
  in	
  body	
  	
  
-­‐ No	
  symptoms	
  	
  
-­‐ Can	
  be	
  passed	
  easily	
  	
  
-­‐ Even	
  w/o	
  symptoms	
  	
  
-­‐ Age	
  21	
  to	
  65	
  years	
  old	
  
-­‐ Cancer	
  Symptoms	
  
-­‐ Avoid	
  Cervical	
  Cancer	
  with	
  pap	
  
smear	
  
HPV
http://www.cdc.gov/std/hpv/stdfact-hpv.htm
33,200HPV-associated cancers occur in the United States each year

http://www.cdc.gov/cancer/hpv/statistics/
20,600HPV-associated cancers occur among females in the United States each year
http://www.cdc.gov/cancer/hpv/statistics/
12,600HPV-associated cancers occur among Males in the United States each year
http://www.cdc.gov/cancer/hpv/statistics/
http://www.cdc.gov/cancer/hpv/statistics/
THERE IS A VACCINE
HPV Vaccines
Cervarix Garasil Gardasil 9
FemalesFemalesFemales
Males Males
• Vaccine only prevents
• 11-12 years old with catch up vaccination up through
• Women can get HPV vaccine through age 26
• Men can get vaccinated through age 21
• Three-dose series
http://www.cdc.gov/hpv/vaccine.html
• Overall	
  Vaccina.on	
  Rates	
  Low	
  
• Not	
  offered	
  by	
  all	
  providers	
  
• Hesitancy	
  among	
  pa.ents	
  
• Hesitancy	
  among	
  providers
Objective
• To measure effectiveness of a
video tool to provide information
targeting HPV and vaccine for
teens
Karabots Center
Karabots Drexel Hill
Research Locations
Urban Setting Suburban Setting
Method
•Scout out patients in eligible age range prior to research
•11-17 years old
•Ask for consent
•Randomize intervention
•VIS (pamphlet) = Placebo
•Noble Medical LLC Video
•Ask questions regarding experience with intervention
•Allow provider to meet with patient
•Follow up patients immediately visit
•Check vaccination records 3 and 6 months later
Recruiting Hurdles
•No show
•Patients by themselves
•No Legal Guardian
•Language barrier
•Extreme Hesitancy
•Autism
•Lack of understanding of HPV
•Consent to sexual activity
•No Interest
•Provider Interruption
Results
Patients
Approached
(n=185)
Enrolled (n=65) Excluded (n=120)
Excluded
(n=120)
Already vaccinated (n=24)
Opted out (n=6)
Adult is not guardian (n=6)
Not interested (n=71)
Non English Speaking (n=3)
Enrolled (n=65)
Intervention
(video) (n=43)
Placebo (VIS)
(n=22)
Gender of Video
Male (n=25) Female (n=18)
Dosage Received
after day zero
encounter
Male 

n(%)
Female Placebo
1st Dose
2nd Dose
3rd Dose
No Doses
19 (79.2)
2 (8.3)
0
3 (12.5)
9 (60) 12 (54.5)
1 (6.7) 3 (13.6)
3 (20) 0
2 (13.3) 7 (31.8)3 (12.5) 2 (13.3) 7 (31.8)
Encounter Location
Drexel Hill
Karabots 63
7
N %
90
10
Guardian Relation
Mother
N %
Father
Grandparent
Step-Parent
61
8
0
0
87.1
0
0
11.4
1 1.4Other
Child’s Gender N %
Female
Male
36
34
51.4
48.6
Average Age 13
Insurance Status
Private
Medicaid
Uninsured
Other
N %
36
31
0
50.0
43.1
0
6.95
“I liked viewing the information on the __ during the
visit” iPad VIS
N (%)
Strongly Disagree (1)
Strongly Agree (5)
Somewhat Agree (4)
Neutral (3)
Somewhat Disagree (2)
N (%)
38 (86.4) 24 (92.3)
1 (3.8)4 (9.1)
0 1 (3.8)
1 (2.3) 0
1 (2.3) 0
“It was easy to view the material presented on
the_____” iPad VIS
N (%)
Strongly Disagree (1)
Strongly Agree (5)
Somewhat Agree (4)
Neutral (3)
Somewhat Disagree (2)
N (%)
40 (90.9) 25 (96.2)
02 (4.5)
0 0
1 (2.3) 0
1 (2.3) 1 (3.8)
“I would like to see more information presented this
way during medical appointments” iPad VIS
N (%)
Strongly Disagree (1)
Strongly Agree (5)
Somewhat Agree (4)
Neutral (3)
Somewhat Disagree (2)
N (%)
32 (72.7) 21 (80.7)
06 (13.6)
2 (4.5) 3
1 (2.3) 0
3 (6.8) 1 (3.8)
“My provider recommended HPV vaccine today” iPad VIS
N (%)
Strongly Disagree (1)
Strongly Agree (5)
Somewhat Agree (4)
Neutral (3)
Somewhat Disagree (2)
N (%)
26 (59.1) 15 (57.7)
1 (3.8)1 (2.3)
12 (27.2) 6 (23.1)
1 (2.3) 1 (3.8)
4 (9.1) 3 (11.5)
“Do you know anyone who has
received or has had their child
received HPV vaccine?”
Yes No
N % %
34 48.6 36 51.4
N
Results
Noble Health LLC Video is slightly more
effective than VIS at informing patients
about HPV and the HPV vaccine
Discussion
• Video slightly more effective
• Effective for patients slightly hesitant
about vaccine
• Consider second Intervention
• Adolescent platform
• Adolescent vaccines
Summary Slide
•HPV (Human Papillomavirus)
•Low Rates
•Intervention Study of 70 patients
•Urban and Suburban CHOP clinics
•2 interventions
•Video is testing variable
•Show video is slightly more effective
SUMR Reflection
• Conduct proper research
• Understand background effort
• Tedious procedure
• maneuver through adversities
• Interest in Vaccine and HPV
• Enjoyed working with patients
• Interest in vaccine access
Thank you for your time
Any Questions?
Thank you!

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CHOP Presentation