Nerve pain can be caused by several underlying diseases and conditions. Common causes include HIV, cancer, diabetes, and certain medications used to treat these conditions. HIV patients often experience nerve pain in the hands and feet as the first symptom of the virus. Cancer and tumors can damage nerves as the growth presses on nerve tissue. Diabetes can lead to nerve damage from high blood sugar levels over time. While there is no permanent cure for nerve pain, natural remedies like omega-3 fatty acids, exercise, and alpha lipoic acid may help relieve symptoms by reducing inflammation and boosting the body's natural painkillers.