![Comparison of the two most common causes of carbapenem resistance
in Enterobacteriaceae: Klebsiella pneumoniae carbapenemase (KPC)
and New Delhi Metallo-β-Lactamase (NDM) type β-lactamases
KPC NDM
β-lactamase type Serine Metallo-β-lactamase
Ambler cass A B
Most commonly affected
species
K. pneumoniae K. pneumoniae
Other species commonly
affected
E. coli, E. cloacae E. coli, E. cloacae
Common MLST types ST258 Variable
Geographic epicenter NE USA India, Pakistan
β-lactam antibiotics affected
Penicillins, cephalosporins,
carbapenems
Penicillins, cephalosporins,
carbapenems
Phenotypic detection
Modified Hodge Test (MHT)
positive
Unknown (positive MHT likely)
Inhibitors Boronic acid EDTA
EDTA: ethylene diaminete traacetic acid.
Reproduced from: Sidjabat H, Nimmo GR, Walsh TR, et al. Carbapenem
Resistance in Klebsiella pneumoniae Due to the New Delhi Metallo-β-
lactamase. Clin Infect Dis 2011; 52:481, by permission of Oxford University
Press. Copyright © 2011.
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C21.21
Licensed to: UpToDate Individual Web - Athanasios Fortis |Support Tag: [1105-46.176.191.203-
5B56F7ACCD-6.14-178457681]
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Carbapenamase2
- 1. Comparison of the two most common causes of carbapenem resistance in Enterobacteriaceae: Klebsiella pneumoniae carbapenemase (KPC) and New Delhi Metallo-β-Lactamase (NDM) type β-lactamases KPC NDM β-lactamase type Serine Metallo-β-lactamase Ambler cass A B Most commonly affected species K. pneumoniae K. pneumoniae Other species commonly affected E. coli, E. cloacae E. coli, E. cloacae Common MLST types ST258 Variable Geographic epicenter NE USA India, Pakistan β-lactam antibiotics affected Penicillins, cephalosporins, carbapenems Penicillins, cephalosporins, carbapenems Phenotypic detection Modified Hodge Test (MHT) positive Unknown (positive MHT likely) Inhibitors Boronic acid EDTA EDTA: ethylene diaminete traacetic acid. Reproduced from: Sidjabat H, Nimmo GR, Walsh TR, et al. Carbapenem Resistance in Klebsiella pneumoniae Due to the New Delhi Metallo-β- lactamase. Clin Infect Dis 2011; 52:481, by permission of Oxford University Press. Copyright © 2011. © 2013 UpToDate, Inc. All rights reserved. | Subscription and License Agreement |Release: 21.2 - C21.21 Licensed to: UpToDate Individual Web - Athanasios Fortis |Support Tag: [1105-46.176.191.203- 5B56F7ACCD-6.14-178457681] Official reprint from UpToDate® www.uptodate.com ©2013 UpToDate® Print | Back