BScN Sympatholytics.pptx

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adnanali979088

Pharmacology

Health & Medicine

CLASSIFICATION OF β-BLOCKERS
According to receptor selectivity
1-Non-selective-(β1 + β2)
Propranolol
Timolol
2- Selective-(β1)
Atenolol
Metoprolol
α and β mixed
Labetalol and Carvedilol
3/11/2023 ANS 2

PHARMACOLOGICAL EFFECTS
Heart :
↓ Force of contraction
↓ Heart rate
↓ Cardiac output
↓ Blood pressure
Lungs:
Bronchoconstriction
3/11/2023 ANS 3

PHARMACOLOGICAL EFFECTS
Skeletal muscle
Inhibits tremor related with anxiety
↓ exercise capacity
Metabolic effect
1- Hyperlipidemia
2- Hypoglycemia
Eye
↓ intraocular pressure by ↓ the secretion of aqueous humor
3/11/2023 ANS 4

$CLINICAL INDICATIONS OF β-BLOCKERS CARDIAC USES : Hypertension Angina Pectoris Myocardial infraction Supraventricular arrhythmias Chronic Congestive Cardiac failure 3/11/2023 ANS 5$

CLINICAL INDICATIONS OF β-BLOCKERS
NON-CARDIAC USES :
Glaucoma
Anxiety
Migraine
Essential tremors
Thyrotoxicosis
Pheochromocytoma
Alcohol or opioids withdrawal symptoms
Portal hypertension
3/11/2023 ANS 6

ADVERSE EFFECTS OF β-BLOCKERS
Cardiac arrhythmias
Sexual impairment
Metabolic disturbances
Hypoglycemia
Hyperlipidemia
Bronchoconstriction
Lethargy
Fatigue
Weakness
3/11/2023 ANS 7

ADVERSE EFFECTS OF β-BLOCKERS
Depression
Dizziness
Visual disturbances
Hallucinations
Short-term memory loss
Emotional liability
Vivid dreams
3/11/2023 ANS 8

CONTRAINDICATIONS OF β-BLOCKERS
Asthma
Heart block
Acute heart failure
Diabetes
Peripheral vascular disease
3/11/2023 ANS 9

CLASSIFICATION OF α-BLOCKERS
BASED ON RECEPTOR SELECTIVITY:
A- SELECTIVE (α1)
Prazosin
Terazosin
Doxazosin
Tamsulosin
C- NON-SELECTIVE (α1, α2 )
Phentolamine
Phenoxybenzamine
3/11/2023 ANS 10

PHARMACOLOGICAL EFFECTS OF α-BLOCKERS
A-CVS:
1-Hypotension
2-Tachycardia
EYES AND NOSE
1-Nasal Congestion
2-Miosis

THERAPEUTIC USES OF α-BLOCKERS
1-Pheochromocytoma
2-Chronic hypertension
3-Benign prostatic hypertrophy (BPH)
4- Peripheral vascular disease

ADVERSE EFFECTS OF α-BLOCKERS
1-Orthostatic hypotension
First dose syncope or First dose effect (Prazosin)
2-Tachycardia
3-Nasal Congestion
4-Inhibition of ejaculation

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