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Benign Prostatic Hyperplasia ( BPH )
Pramod Bhandari
Intern
Department of General Surgery
Gandaki Medical College
(2074-12-25)
Case Presentation
Patient Profile
• Age/Sex: 61 y/ male
• Address: Baglung
• Date of Admission: 2074-12-22
Chief Complain
• Increased frequency of micturation for 2 years
• Dribbling of urine for 2 years
History of present illness
• Started to pass urine frequently during day i.e. 3-4 times
within an hour
• Woke up 3-4 times at night to pass urine
• Insidious and gradually progressive
• Inability to hold urine once he had desire to pass it
• Also soiled his undergarments
• Had to strain to start act of micturation
• Associated with thinning of stream followed by passage of
urine in drops wetting his undergarments
• Bladder was not completely empty
Past History
• Hemorrhoidectomy 30 years back
• Right inguinal hernioplasty 25 years back
• No history of trauma, instrumentation
• No history of Tuberculosis, Diabetes and HTN
Allergy History
• Not allergic to known food and drugs.
Family History
• No history of similar illness in the family
• No history of TB, DM and HTN in family members
Personal History
• Mixed diet
• Occasional drinker
• Left smoking 8 years back (used to smoke 20 pack year)
On Examination
• General condition
– Conscious, co-operative, well oriented to time, place and
person . No signs of respiratory distress.
• No evidence pallor, icterus, lymphadenopathy, clubbing,
cyanosis, oedema and dehydration.
• Vitals: Within normal limits
Systemic Examination
• Per abdominal:
Soft, non-tender
Approx. 5*3 cm2, non- tender, reducible buldge seen in left
inguinal region on straining, cough impulse positive
Bowel sound present
• Per rectal examination:
Smooth , rubbery swelling can be felt anteriorly in Rectum
Rectal mucosa can be freely moved over it
• Respiratory system: Bilaterally clear
• Cardiovascular system: first and second heart sound heard, no
murmur
Investigations
• Blood examination
• CBC- Within Normal limits
• Serology- Non reactive
• PT-INR: 1
• Ultarasonography (2074-11-29)
• Thickened and irregular urinary bladder wall
• Grade I prostatomegaly
• Uroflowmerty
 Voided volume 124 ml
 Max flow rate 5 ml/s
 Avg. flow rate 2 ml/s
 Post voidal residual volume 180 ml
• Cystoscopy
 Trilobar enlargement
 Some trabeculations with multiple saccules
Diagnosis
• Benign Prostatic Hyperplasia with left inguinal hernia
Management
• Surgical procedure: Transurethral resection of prostate
Spinal Anesthesia on 2074-12-23.
OT Findings
• Moderately enlarged prostate
• Severe trabeculations with saccules
Post Operative Course
• Irrigation contiued with 3 ways foley’s catheter
• IVF NS and Dextrose
• Inj. Cefriaxone
• Inj. Ketorolac
• Inj. Pantoprazole
• Inj. Tramadol
• Inj. Ondensetron
First post-op day:
• Shifted to ward
• Irrigation continued
• Inj. Ceftriaxone
• Tab. Ketorolac
• Tab. Pantoprazole
• Tab. Binfin
Benign Prostatic Hyperplasia
Anatomy of Prostate:
Etiology:
Theories
1. Hormonal
• Due to imbalance between androgen and estrogen
• Androgen level falls with increasing age but fall in
estrogen level is not equal
2. Neoplastic Theory:
• BPH is considered to be a benign neoplasm; adenoma.
Clinical Features:
• Urgency, Hesitency, Nocturia
• Overflow and terminal dribbling
• Difficulty in micturation with weak stream and dribble
• Acute retention of urine
• Tenderness in suprapubic region
• Feartures of UTI
• DRE: Enlarged prostate
Lower urinary tract symptoms (LUTS)
 Symptoms of voiding:
• Hesitency
• Poor flow
• Intermittent stream- stops and starts
• Dribbling
• Sensation of poor emptying of bladder
• Episodes of near retention
 Symptoms of storage
• Frequency
• Nocturia
• Urgency
• Urge incontinence
• Nocturnal incontinence
International Prostate Symptoms Score:
 Assesment:
Score;
• 0-7 : mild symptomatic
• 8-19 : moderately symptomatic
• 20-35: severely symptomatic
Differential Diagnosis:
• Urethral Stricture
• Bladder Tumor, Carcinoma Prostate
• Bladder Neck stenosis
Investigations
• Urine microscopy and culture
• Blood urea and serum creatinine
• Ultrasonography of abdomen and pelvis
• Urodynamic studies
• Cystoscopy
• Transrectal U/S
• Acid phosphatase
• Prostate Specific antigen (PSA)
• Intravenous Urography
• Serum Electrolytes
Management:
1. Conservative
• Wait and watch
• Urethral Catheterisation
• Spurapubic Cystostomy
• Correction of serum electrolytes
• Drugs:
o Alpha adrenergic blocker: Prazosin, Tamsulosin
o 5 alpha reductase inhibitor: Finasteride
2. Surgery
 Indications :
• Prostatism (frequency, urgency, dysuria)
• Acute retention of urine
• Chronic retention of urine with residual urine more than
200 ml
• Complications like hydroureter, hydronephrosis, recurrent
infection, stone formation
 Surgery Options
a. Conventional surgical options
i. Transurethral resection of prostate (TURP)
ii. Retropubic prostatectomy (Millin’s)
iii. Transvesical prostatectomy (Freyer’s)
iv. Perineal prostatectomy (Young’s)
b. Minimally invasive therapy
i. Laser therpy: Using Holmium
ii. Transurethral needle ablation of prostate
iii. Microwave hyperthermia with temp. of 45-50degree
iv. Prostatic urethral stents
v. Transurethral dilatation of prostate
Complications:
1. Local
a. Hemorrhage
b. Perforation of bladder
c. Incontinence
d. Retrograde ejaculaton
e. Urethral stricture
2. Systemic
a. Cardiovascular and pulmonary:
Atelectasis, pneumonia, myocardial infarction,
congestive cardiac failure, Deep vein thrombosis
b. Water intoxication (TURP syndrome)
Absorption of water leading to congestive cardiac
failure, hyponatremia and hemolysis.
Refrences
• Hamilton Bailey and McNeill Love.(2012) Bailey and Love’s
SHORT PRACTICE of SURGERY. 26th Edition. New York:
CRC Press
• Sriram Bhat M. (2013) SRB’s MANUAL OF SURGERY. 4th
Edition. New Delhi: Jaypee Brothers Medical Publishers
THANK YOU

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Bph

  • 1. Benign Prostatic Hyperplasia ( BPH ) Pramod Bhandari Intern Department of General Surgery Gandaki Medical College (2074-12-25)
  • 3. Patient Profile • Age/Sex: 61 y/ male • Address: Baglung • Date of Admission: 2074-12-22
  • 4. Chief Complain • Increased frequency of micturation for 2 years • Dribbling of urine for 2 years
  • 5. History of present illness • Started to pass urine frequently during day i.e. 3-4 times within an hour • Woke up 3-4 times at night to pass urine • Insidious and gradually progressive • Inability to hold urine once he had desire to pass it • Also soiled his undergarments
  • 6. • Had to strain to start act of micturation • Associated with thinning of stream followed by passage of urine in drops wetting his undergarments • Bladder was not completely empty
  • 7. Past History • Hemorrhoidectomy 30 years back • Right inguinal hernioplasty 25 years back • No history of trauma, instrumentation • No history of Tuberculosis, Diabetes and HTN
  • 8. Allergy History • Not allergic to known food and drugs. Family History • No history of similar illness in the family • No history of TB, DM and HTN in family members
  • 9. Personal History • Mixed diet • Occasional drinker • Left smoking 8 years back (used to smoke 20 pack year)
  • 10. On Examination • General condition – Conscious, co-operative, well oriented to time, place and person . No signs of respiratory distress. • No evidence pallor, icterus, lymphadenopathy, clubbing, cyanosis, oedema and dehydration. • Vitals: Within normal limits
  • 11. Systemic Examination • Per abdominal: Soft, non-tender Approx. 5*3 cm2, non- tender, reducible buldge seen in left inguinal region on straining, cough impulse positive Bowel sound present
  • 12. • Per rectal examination: Smooth , rubbery swelling can be felt anteriorly in Rectum Rectal mucosa can be freely moved over it • Respiratory system: Bilaterally clear • Cardiovascular system: first and second heart sound heard, no murmur
  • 13. Investigations • Blood examination • CBC- Within Normal limits • Serology- Non reactive • PT-INR: 1 • Ultarasonography (2074-11-29) • Thickened and irregular urinary bladder wall • Grade I prostatomegaly
  • 14. • Uroflowmerty  Voided volume 124 ml  Max flow rate 5 ml/s  Avg. flow rate 2 ml/s  Post voidal residual volume 180 ml • Cystoscopy  Trilobar enlargement  Some trabeculations with multiple saccules
  • 15. Diagnosis • Benign Prostatic Hyperplasia with left inguinal hernia
  • 16. Management • Surgical procedure: Transurethral resection of prostate Spinal Anesthesia on 2074-12-23. OT Findings • Moderately enlarged prostate • Severe trabeculations with saccules
  • 17. Post Operative Course • Irrigation contiued with 3 ways foley’s catheter • IVF NS and Dextrose • Inj. Cefriaxone • Inj. Ketorolac • Inj. Pantoprazole • Inj. Tramadol • Inj. Ondensetron
  • 18. First post-op day: • Shifted to ward • Irrigation continued • Inj. Ceftriaxone • Tab. Ketorolac • Tab. Pantoprazole • Tab. Binfin
  • 21. Etiology: Theories 1. Hormonal • Due to imbalance between androgen and estrogen • Androgen level falls with increasing age but fall in estrogen level is not equal
  • 22. 2. Neoplastic Theory: • BPH is considered to be a benign neoplasm; adenoma.
  • 23. Clinical Features: • Urgency, Hesitency, Nocturia • Overflow and terminal dribbling • Difficulty in micturation with weak stream and dribble • Acute retention of urine • Tenderness in suprapubic region • Feartures of UTI • DRE: Enlarged prostate
  • 24. Lower urinary tract symptoms (LUTS)  Symptoms of voiding: • Hesitency • Poor flow • Intermittent stream- stops and starts • Dribbling • Sensation of poor emptying of bladder • Episodes of near retention
  • 25.  Symptoms of storage • Frequency • Nocturia • Urgency • Urge incontinence • Nocturnal incontinence
  • 27.  Assesment: Score; • 0-7 : mild symptomatic • 8-19 : moderately symptomatic • 20-35: severely symptomatic
  • 28. Differential Diagnosis: • Urethral Stricture • Bladder Tumor, Carcinoma Prostate • Bladder Neck stenosis
  • 29. Investigations • Urine microscopy and culture • Blood urea and serum creatinine • Ultrasonography of abdomen and pelvis • Urodynamic studies • Cystoscopy
  • 30. • Transrectal U/S • Acid phosphatase • Prostate Specific antigen (PSA) • Intravenous Urography • Serum Electrolytes
  • 31. Management: 1. Conservative • Wait and watch • Urethral Catheterisation • Spurapubic Cystostomy • Correction of serum electrolytes • Drugs: o Alpha adrenergic blocker: Prazosin, Tamsulosin o 5 alpha reductase inhibitor: Finasteride
  • 32. 2. Surgery  Indications : • Prostatism (frequency, urgency, dysuria) • Acute retention of urine • Chronic retention of urine with residual urine more than 200 ml • Complications like hydroureter, hydronephrosis, recurrent infection, stone formation
  • 33.  Surgery Options a. Conventional surgical options i. Transurethral resection of prostate (TURP) ii. Retropubic prostatectomy (Millin’s) iii. Transvesical prostatectomy (Freyer’s) iv. Perineal prostatectomy (Young’s)
  • 34. b. Minimally invasive therapy i. Laser therpy: Using Holmium ii. Transurethral needle ablation of prostate iii. Microwave hyperthermia with temp. of 45-50degree iv. Prostatic urethral stents v. Transurethral dilatation of prostate
  • 35. Complications: 1. Local a. Hemorrhage b. Perforation of bladder c. Incontinence d. Retrograde ejaculaton e. Urethral stricture
  • 36. 2. Systemic a. Cardiovascular and pulmonary: Atelectasis, pneumonia, myocardial infarction, congestive cardiac failure, Deep vein thrombosis b. Water intoxication (TURP syndrome) Absorption of water leading to congestive cardiac failure, hyponatremia and hemolysis.
  • 37. Refrences • Hamilton Bailey and McNeill Love.(2012) Bailey and Love’s SHORT PRACTICE of SURGERY. 26th Edition. New York: CRC Press • Sriram Bhat M. (2013) SRB’s MANUAL OF SURGERY. 4th Edition. New Delhi: Jaypee Brothers Medical Publishers