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Botulinum toxin in cerebral palsy
• Available in powder form
• Acts on motor end plates
• Stop the release of acetylcholine
• So, decreases the muscle activity of spastic
muscle .
• This injection is more effective in younger
children .. Recommended age is 2-6 years
• Recommended dose in one go is 300 IU
• Given in hamstrings , rectus femoris ,
gastronemius , iliopsoas , tibialis posterior
• Also given in pronator teres , flexor carpi
ulnaris and adductor pollicis
• Posture and gait pattern improves within a
week.
• Its not a permanent form of treatment
• After 6 months to 1 year , effect started
weaning off.

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Botulinum toxin in cerebral palsy

  • 1. Botulinum toxin in cerebral palsy • Available in powder form • Acts on motor end plates • Stop the release of acetylcholine • So, decreases the muscle activity of spastic muscle . • This injection is more effective in younger children .. Recommended age is 2-6 years • Recommended dose in one go is 300 IU
  • 2. • Given in hamstrings , rectus femoris , gastronemius , iliopsoas , tibialis posterior • Also given in pronator teres , flexor carpi ulnaris and adductor pollicis • Posture and gait pattern improves within a week. • Its not a permanent form of treatment • After 6 months to 1 year , effect started weaning off.