Biacore Molecular Interactions

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The document describes the Biacore Molecular Interactions Shared Resource (BMISR) and its capabilities. The BMISR uses a Biacore T-100 system to detect and characterize molecular interactions in real-time without labelling. It can be used to determine if and how strongly two molecules interact, identify binding partners, and characterize affinity and kinetics. Examples of applications mentioned include studying protein-DNA, small molecule-protein, protein-peptide, and protein-RNA interactions.

Technology

Biacore Molecular Interactions Shared Resource (BMISR) Aykut Uren, MD, Director [email_address]

BMISR ,[object Object],[object Object],[object Object]

What can you use? ,[object Object],[object Object],[object Object],[object Object]

What can you do? Detect Binding Yes/No Identify Specificity Binding Partners Characterize Affinity Kinetics Concentration Thermodynamics

Biacore T-100 Integrated Microfluidics Gold Sensor Chip SPR Detection System

Biacore T-100 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Sample Applications (Chang) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Protein peptide interactions Protein RNA interactions

Shared Resources are partially supported by the Georgetown Howard University Center for Clinical and Translational Studies (GHUCCTS) 1UL1RR031975-01 In your publications, remember to mention support provided from the GHUCCTS.

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