Assignments

1. Pathogenesis of Atopic
Dermatitis
Siti Nurul Afiqah binti Johari
10-5-95

2. Atopic dermatitis
(AD) is a highly pruritic, recurring
inflammatory skin disease. It usually
develops in early childhood and is frequently
seen in children with a personal history of
respiratory allergy and/or a family history of
atopic disease.

3. Barrier function of skin

4. Skin barrier dysfunction
1. Ceramide deficiency
• Ceramides are main source of essential FA, a
key role in epidermal barrier function.
• Acts as a water modulator and permeability
barrier
• Decrease in ceramide level is main
attributable factor in barrier disrupted dry
skin of AD

6. 2. Filaggrin loss-of-function mutations

7. FLG
mutations
Corneocyte
deformation
Disruption of
organisation of
extracellular
lipid
Reduction in
NMFs
Increase in pH
Impaired
antimicrobial
properties
(S.aureus)

8. Immunopathologic mechanisms

10. Environment