Asthma - Dupixent - Sanofi
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Dupixent® by Sanofi received FDA marketing authorization in October 2018 for use as an add-on maintenance therapy in patients aged 12 years and older with moderate-to-severe asthma, particularly those with an eosinophilic phenotype or other specific conditions. In May 2019, the European Commission granted approval for Dupixent® to serve as an add-on maintenance treatment in patients aged 12 years and older who have severe asthma with type 2 inflammation and are inadequately controlled by high-dose inhaled corticosteroids, in conjunction with another maintenance medicinal product.
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U.S. Lupus Nephritis Market
The lupus nephritis biologics market, as of the current year (2019), stands at USD $243.07 million, with an anticipated growth rate of 9.0% for the period 2020 to 2026. In parallel, the market for the targeted biologic molecule X was valued at USD $24.31 million in 2019, and it is projected to experience a significant growth rate of 20.0% from 2020 to 2026.
Within the population of lupus nephritis patients, approximately 0.39 million individuals are affected, with 0.08 million of them opting for biologic treatments. In the case of the targeted biologic molecule X, it is chosen by 0.01 million patients suffering from lupus nephritis.
Notably, there are 152 ongoing clinical studies dedicated to the condition of lupus nephritis. Leading players in these clinical studies include F. Hoffmann-La Roche Ltd, Astellas Pharma Inc, Novartis, Bristol-Myers Squibb, and Aurinia Pharmaceuticals Inc.
Introduction:
Lupus nephritis is a chronic complication arising from systemic lupus erythematosus (SLE) and primarily affects the kidneys. SLE, an autoimmune disease where the body's immune system targets healthy cells and organs, is the underlying cause. Lupus nephritis is more prevalent in women, often occurring during their childbearing years.
Symptoms of lupus nephritis include foamy urine, edema (swelling, especially in areas with excess fluid, like legs, ankles, and feet), and the presence of blood in the urine.
Diagnosis:
Diagnosing lupus nephritis involves urine tests, blood tests, kidney biopsies, and ultrasound examinations.
Lupus Nephritis Patient Pool:
In the United States, there are approximately 0.58 million patients afflicted with Systemic Lupus Erythematosus, with 0.39 million of them experiencing lupus nephritis. Systemic Lupus Erythematosus has a prevalence rate of 150 cases per 100,000 and an incidence rate of 25 cases per 100,000. The prevalence rate for lupus nephritis is 20 cases per 100,000 persons.
Plant Biotechnology Market
Plant Biotechnology: Executive Summary:-
The global plant biotechnology market is growing at 6.7% CAGR over the forecast year of 2018-2027
Technology wise, Genomics segment show the major share 38.6% in 2018
By Region, Asia Pacific Countries show highest growth rate of 7.1% over the forecast period
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Genomics: The study of function , structure and other genetic details of a organisms. Using various tools:
PCR: Polymerase chain reaction is the process for amplify, making copy from a single DNA.
Sequencing: Sequencing is a precise order of a nucleotides in molecule.
Gene Editing: Genetic engineering process in which genome is modified within a living cell through the insertion, deletion, or replacement of one or more segments of DNA.
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Market Insight: Roxadustat, the approved drug, is the pioneer in the class of hypoxia-inducible factor prolyl hydroxylase inhibitors. Its potential market could reach a billion dollars in the years to come.
Patient Pool: Globally, an estimated 10-12% of the adult population suffers from CKD, with over 14% of the adult population in the United States affected by CKD, as reported by the United States Renal Data System (USRDS).
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Anemia is a common condition associated with Chronic Kidney Disease (CKD), encompassing myelodysplastic syndromes (MDS) and chemotherapy-induced anemia (CIA).
Anemia often develops in the early stages of CKD, typically when kidney function is reduced to 20-50% of normal capacity. Its severity tends to increase as CKD progresses.
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Complications may include irregular or unusually rapid heartbeats.
Introduction to Roxadustat: Roxadustat is a small molecule hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor.
Route of Administration: Roxadustat is administered orally.
Treatment Scope: Roxadustat is used for the treatment of anemia in patients with dialysis-dependent chronic kidney disease (CKD), non-dialysis-dependent CKD, and those with myelodysplastic syndromes.
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Asthma exhibits a prevalence rate ranging from 15-20% in many countries, with the United States having a prevalence rate of 7.6%. Globally, asthma affects 339 million individuals. Patients suffering from asthma often take anti-inflammatories and anticholinergics as medications.
Prominent players in the asthma market include Teva Pharmaceutical Industries Ltd., Merck & Co., AstraZeneca Plc, GlaxoSmithKline Plc, Sanofi-Aventis SA, Philips Healthcare, Sunovion Pharmaceuticals, CareFusion Corporation, Inc., Boehringer Ingelheim GmbH, and Roche.
Asthma is a chronic respiratory condition characterized by narrowed airways, inflammation, and excess mucus production, resulting in breathing difficulties.
Causes of asthma include environmental factors, genetic predisposition, a history of viral infections, and the hygiene hypothesis.
Common symptoms encompass shortness of breath, anxiety or panic, chest tightness or pain, and coughing or wheezing attacks.
Diagnosis involves no single definitive test; doctors typically inquire about respiratory history and conduct physical examinations. Additional tests for lung conditions include spirometry, peak flow measurements, and various diagnostic procedures like allergy testing, sputum eosinophil assessment, methacholine challenges, nitric oxide tests (FeNO), and imaging tests.
Treatment strategies encompass breathing exercises, quick-acting treatments, long-term asthma control medications, anti-inflammatories, anticholinergics, long-acting bronchodilators, and biologic therapy drugs. Medications may be administered orally or via inhalation, with corticosteroids such as fluticasone, mometasone, budesonide, ciclesonide, beclomethasone, flunisolide, and others being common choices.
Acute myeloid leukemia
Acute myeloid leukemia originates in the bone marrow from immature white blood cells, specifically granulocytes or monocytes.
In the realm of drug therapy, the potential market for AML Type (AML with t(8;21)(q22;q22); (RUNX1;RUNX1T1)) was valued at USD$ 22.21 million in 2020. This particular AML subtype market is anticipated to exhibit a compound annual growth rate (CAGR) of 6.3% from 2021 to 2030.
Notably, Novartis is directing its attention toward newly diagnosed patients with FLT3-mutated acute myeloid leukemia. The key therapeutic solution on the horizon is Midostaurin 50 mg, expected to be launched in the coming years, promising advancements in treatment options for this patient group.
Acute myeloid leukemia (AML) is classified into various groups or systems, including the French-American-British (FAB) system and the World Health Organization (WHO) system.
The FAB system categorizes AML based on the appearance of leukemia cells under the microscope and the presence of specific antibody proteins on these cells. In contrast, the WHO system classifies AML by considering myeloid cells and the presence of abnormal chromosomal (genetic) changes within these cells.
The WHO system is commonly referenced, as it places a significant emphasis on the genetic makeup of leukemia cells, making it a valuable tool for predicting prognosis. Molecular biomarkers are employed for this purpose and to forecast responses to approved targeted therapies in AML patients.
A variety of molecular biomarkers and genetic alterations, including karyotypes, chromosomal translocations, inversions, deletions, and gene mutations, have been identified as prognostic indicators in AML.
Second-line induction therapy is the quickest path to regulatory approval for adult patients with relapsed or refractory AML. Notably, Annamycin has shown promise as a second-line induction therapy for these patients.
The FDA has approved several therapies for refractory or relapsed AML, such as Enasidenib (Idhifa®), Gemtuzumab ozogamicin (MylotargTM), Ivosidenib (Tibsovo®), and Gilteritinib (Xospata®).
Effective pricing is essential to ensure that these drugs are accessible to patients.
Clinical effectiveness plays a crucial role in shaping the drug market for AML treatments.
Industry players are placing increased focus on specific mutations, as evidenced by clinical studies conducted by companies like Arog Pharmaceuticals, Inc. (founded in 2010), which is currently studying AML patients with FLT3 activation mutations (Clinical Trial Identifier: NCT01657682).
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Under the brand name "Oxra®," Sun Pharma will undertake the promotion and distribution of dapagliflozin. This medication is approved for use in the United States as a monotherapy and in combination therapy to enhance glycemic control in patients with type 2 diabetes.
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The lupus nephritis biologics market, as of the current year (2019), stands at USD $243.07 million, with an anticipated growth rate of 9.0% for the period 2020 to 2026. In parallel, the market for the targeted biologic molecule X was valued at USD $24.31 million in 2019, and it is projected to experience a significant growth rate of 20.0% from 2020 to 2026.
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Lupus nephritis is a chronic complication arising from systemic lupus erythematosus (SLE) and primarily affects the kidneys. SLE, an autoimmune disease where the body's immune system targets healthy cells and organs, is the underlying cause. Lupus nephritis is more prevalent in women, often occurring during their childbearing years.
Symptoms of lupus nephritis include foamy urine, edema (swelling, especially in areas with excess fluid, like legs, ankles, and feet), and the presence of blood in the urine.
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Diagnosing lupus nephritis involves urine tests, blood tests, kidney biopsies, and ultrasound examinations.
Lupus Nephritis Patient Pool:
In the United States, there are approximately 0.58 million patients afflicted with Systemic Lupus Erythematosus, with 0.39 million of them experiencing lupus nephritis. Systemic Lupus Erythematosus has a prevalence rate of 150 cases per 100,000 and an incidence rate of 25 cases per 100,000. The prevalence rate for lupus nephritis is 20 cases per 100,000 persons.
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Plant Biotechnology: Executive Summary:-
The global plant biotechnology market is growing at 6.7% CAGR over the forecast year of 2018-2027
Technology wise, Genomics segment show the major share 38.6% in 2018
By Region, Asia Pacific Countries show highest growth rate of 7.1% over the forecast period
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PCR: Polymerase chain reaction is the process for amplify, making copy from a single DNA.
Sequencing: Sequencing is a precise order of a nucleotides in molecule.
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Proteomics: The technology which allow to change the genetic material by removing, adding or changing the location in the genome.
Transcriptomics: The process to study a transcriptome (sum of all RNA molecules).
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Complications may include irregular or unusually rapid heartbeats.
Introduction to Roxadustat: Roxadustat is a small molecule hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor.
Route of Administration: Roxadustat is administered orally.
Treatment Scope: Roxadustat is used for the treatment of anemia in patients with dialysis-dependent chronic kidney disease (CKD), non-dialysis-dependent CKD, and those with myelodysplastic syndromes.
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Prominent players in the asthma market include Teva Pharmaceutical Industries Ltd., Merck & Co., AstraZeneca Plc, GlaxoSmithKline Plc, Sanofi-Aventis SA, Philips Healthcare, Sunovion Pharmaceuticals, CareFusion Corporation, Inc., Boehringer Ingelheim GmbH, and Roche.
Asthma is a chronic respiratory condition characterized by narrowed airways, inflammation, and excess mucus production, resulting in breathing difficulties.
Causes of asthma include environmental factors, genetic predisposition, a history of viral infections, and the hygiene hypothesis.
Common symptoms encompass shortness of breath, anxiety or panic, chest tightness or pain, and coughing or wheezing attacks.
Diagnosis involves no single definitive test; doctors typically inquire about respiratory history and conduct physical examinations. Additional tests for lung conditions include spirometry, peak flow measurements, and various diagnostic procedures like allergy testing, sputum eosinophil assessment, methacholine challenges, nitric oxide tests (FeNO), and imaging tests.
Treatment strategies encompass breathing exercises, quick-acting treatments, long-term asthma control medications, anti-inflammatories, anticholinergics, long-acting bronchodilators, and biologic therapy drugs. Medications may be administered orally or via inhalation, with corticosteroids such as fluticasone, mometasone, budesonide, ciclesonide, beclomethasone, flunisolide, and others being common choices.
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Acute myeloid leukemia originates in the bone marrow from immature white blood cells, specifically granulocytes or monocytes.
In the realm of drug therapy, the potential market for AML Type (AML with t(8;21)(q22;q22); (RUNX1;RUNX1T1)) was valued at USD$ 22.21 million in 2020. This particular AML subtype market is anticipated to exhibit a compound annual growth rate (CAGR) of 6.3% from 2021 to 2030.
Notably, Novartis is directing its attention toward newly diagnosed patients with FLT3-mutated acute myeloid leukemia. The key therapeutic solution on the horizon is Midostaurin 50 mg, expected to be launched in the coming years, promising advancements in treatment options for this patient group.
Acute myeloid leukemia (AML) is classified into various groups or systems, including the French-American-British (FAB) system and the World Health Organization (WHO) system.
The FAB system categorizes AML based on the appearance of leukemia cells under the microscope and the presence of specific antibody proteins on these cells. In contrast, the WHO system classifies AML by considering myeloid cells and the presence of abnormal chromosomal (genetic) changes within these cells.
The WHO system is commonly referenced, as it places a significant emphasis on the genetic makeup of leukemia cells, making it a valuable tool for predicting prognosis. Molecular biomarkers are employed for this purpose and to forecast responses to approved targeted therapies in AML patients.
A variety of molecular biomarkers and genetic alterations, including karyotypes, chromosomal translocations, inversions, deletions, and gene mutations, have been identified as prognostic indicators in AML.
Second-line induction therapy is the quickest path to regulatory approval for adult patients with relapsed or refractory AML. Notably, Annamycin has shown promise as a second-line induction therapy for these patients.
The FDA has approved several therapies for refractory or relapsed AML, such as Enasidenib (Idhifa®), Gemtuzumab ozogamicin (MylotargTM), Ivosidenib (Tibsovo®), and Gilteritinib (Xospata®).
Effective pricing is essential to ensure that these drugs are accessible to patients.
Clinical effectiveness plays a crucial role in shaping the drug market for AML treatments.
Industry players are placing increased focus on specific mutations, as evidenced by clinical studies conducted by companies like Arog Pharmaceuticals, Inc. (founded in 2010), which is currently studying AML patients with FLT3 activation mutations (Clinical Trial Identifier: NCT01657682).
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Under the brand name "Oxra®," Sun Pharma will undertake the promotion and distribution of dapagliflozin. This medication is approved for use in the United States as a monotherapy and in combination therapy to enhance glycemic control in patients with type 2 diabetes.
In China, the National Medical Products Administration (NMPA) approved dapagliflozin, both in combination with metformin and as a standalone treatment, for inadequately-controlled type-2 diabetes mellitus. It was introduced for the treatment of type 2 diabetes in China in 2018.
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The Shanghai Shenkang Hospital Development Center has outlined a three-year plan to promote clinical skills and innovations in municipal hospitals, reflecting a commitment to healthcare advancements.
Efforts are being made to expand distribution channels across diverse geographical regions. AstraZeneca is closely monitoring the Indian market to secure a significant share and prevent the infringement of dapagliflozin by generic manufacturers.
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ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
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ACCORDING TO apic.org,
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VISION
Being proactive
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being to preserve human and animal health and the effectiveness of antimicrobial medications.
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to prevent antimicrobial overuse, misuse and abuse.
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2024 State of Marketing Report – by Hubspot
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
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· Authentic influencer partnerships fuel brand growth
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Technology
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Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
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- 3. THANK YOU