Abstract Summary: ASRAFifth
Edition Guidelines
• • Hemorrhagic complications from regional
anesthesia are extremely rare.
• • The 5th edition of ASRA’s Evidence-Based
Guidelines (2025) reviews data since 2018.
• • Maintains an 'antihemorrhagic' (patient-
safety first) approach due to limited RCT
evidence.
• • Shifts terminology: 'low dose' and 'high
dose' replace 'prophylactic' and 'therapeutic'
Editor's Notes
#1
Speaker Notes:
- Emphasize the rarity of hemorrhagic complications in regional anesthesia.
- Highlight ASRA’s ongoing commitment to patient safety through conservative, evidence-informed approaches.
- Explain why randomized trials are impractical for such rare events.
- Discuss terminology update from “prophylactic/therapeutic” to “low/high dose” for better clinical accuracy.
- Mention the inclusion of drug-specific assays as a new practice tool.
- Conclude by noting that each recommendation now specifies its evolution from earlier versions.