Apss2010 abstract
•Download as DOC, PDF•
0 likes•205 views
This study explored the relationship between absolute beta power during REM sleep and regional cerebral glucose metabolism in 10 adults with primary insomnia. Regression analyses found significant negative correlations - decreased beta activity was associated with increased glucose metabolism in three brain areas. These areas included the left frontal cortex and bilateral temporal and parietal cortices. These preliminary results suggest decreased beta power during REM sleep in primary insomnia may reflect increased activity in posterior brain regions involved in quiet, resting states. However, larger sample sizes are needed to replicate these findings.
Report
Share
Report
Share
![The Relationship Between Absolute Beta Power and rCMRglc in Primary Insomnia
during REM Sleep.
Alman J, Miewald J, Cashmere D, Nofzinger E, Buysse DJ, Germain A
Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
Introduction: Primary Insomnia (PI) is characterized by increased arousal and poor
sleep. However, the neurobiological correlates of PI during REM sleep have been
scarcely studied. We explored the relationship between whole-night absolute beta power
during REM sleep and relative regional cerebral metabolic rate of glucose (rCMRglc) in
adults with PI.
Methods: Ten PI subjects (mean age 37.86±9.38 years) were included in this analysis.
All were medication free and completed 3 nights of polysomnographic recordings and
[18F]-fluoro-2-deoxy-D-glucose positron emission tomography scans during REM sleep.
Regression analyses were conducted to evaluate the correlations between whole-night
REM sleep absolute power spectral values for beta2 activity (16-32 Hz) and rCMRglc.
Results: No significant positive correlation between beta activity and rCMRglc during
REM sleep was observed. Significant negative correlations between beta activity and
rCMRglc during REM sleep were observed in three brain areas. The first area (x, y, z,
coordinates: -10, 48, 10, Z=3.36, P=0.03) included the left inferior and middle frontal
gyri and extended into cingulate gyrus. The largest area (x, y, z, coordinates: 52, -66, 14,
Z=4.15, P<.001) encompassed the right inferior, middle, and superior temporal gyri and
the fusiform gyrus, parahippocampal gyrus and hippocampus. Bilaterally, it also included
the posterior cingulate, precuneus, and superior parietal lobule. The last area (x, y, z,
coordinates: -34, -44, -20, Z=4.38, P=.04) included the left fusiform gyrus, superior,
inferior, and middle temporal gyri.
Conclusion: In adults with PI, decreased whole-night beta activity was associated with
increased rCMRglc during REM sleep in the temporal and parietal cortices bilaterally and
in the left frontal regions. Posterior brain regions have been related to quiet, resting
states. Replication of these preliminary results in large samples is required.
Support: This research was supported by the National Institutes of Health (MH053035;
MH024652; MH66227; RR024153) and the Department of Defense (PT073961-
W81XWH-07-PTSD-IIRA).](https://image.slidesharecdn.com/apss2010abstract-120428100916-phpapp02/85/Apss2010-abstract-1-320.jpg)
Recommended
Lateral inhibition
Lateral inhibition refers to the inhibition of neighboring neurons in the brain pathways when activated simultaneously. In the visual system, neighboring pathways from receptors to the optic nerve show lateral inhibition, meaning neighboring visual neurons respond less when activated together than when one is activated alone. This increases the contrast between strong and weak signals perceived in the brain.
Poster Human Neurophysiology
This is a poster which describes an experiment which was executed by our group. A part was our own experiment (the i-Doser part) and the other part was classical.
We came up with the i-Doser experiment, which was voted as the winning experiment. Furthermore, our poster was chosen as the best poster out of all the other posters. (June 2010)
Concept _
The Heartbreak Kid is a comedy film starring Bill Stiller about a man named Eddie who rushes into marriage with his new girlfriend Lila, only to discover on their honeymoon that she is awful and crazy. While trying to hide his new marriage from his dream girl Miranda, Eddie finds himself in hilarious predicaments. The film is directed by the Farrelly Brothers and is loosely based on a 1975 film of the same name. It is expected to be another comedy hit from the duo known for films like There's Something About Mary and Dumb and Dumber.
Mapa Coonceptual Jean piaget
El documento describe las etapas del desarrollo de la inteligencia y la adquisición del lenguaje según Jean Piaget, incluyendo la etapa sensoriomotora desde los 0 a los 2 años, la preoperacional desde los 2 a los 7 años, las operaciones concretas desde los 7 a los 12 años y las operaciones formales desde los 12 a los 15 años. Cada etapa se caracteriza por diferentes habilidades lingüísticas y cognitivas.
Tudo sobre investimentos
Estudo deenvolvida pela Cyrela indicando principais pontos que justificam investimento em imoveis.
cam lqm 1082 g 919
This document is a marksheet for a Quranic Language Department course in the 2011/2012 semester. It lists 21 students with their matriculation numbers and names. It provides their marks for midterm exams, quizzes, oral exams, activities, and final exams, which are combined for a grand total out of 100. Most students received grades of C, D, or E, with scores ranging from 35 to 54 out of 100.
Recommended
Lateral inhibition
Lateral inhibition refers to the inhibition of neighboring neurons in the brain pathways when activated simultaneously. In the visual system, neighboring pathways from receptors to the optic nerve show lateral inhibition, meaning neighboring visual neurons respond less when activated together than when one is activated alone. This increases the contrast between strong and weak signals perceived in the brain.
Poster Human Neurophysiology
This is a poster which describes an experiment which was executed by our group. A part was our own experiment (the i-Doser part) and the other part was classical.
We came up with the i-Doser experiment, which was voted as the winning experiment. Furthermore, our poster was chosen as the best poster out of all the other posters. (June 2010)
Concept _
The Heartbreak Kid is a comedy film starring Bill Stiller about a man named Eddie who rushes into marriage with his new girlfriend Lila, only to discover on their honeymoon that she is awful and crazy. While trying to hide his new marriage from his dream girl Miranda, Eddie finds himself in hilarious predicaments. The film is directed by the Farrelly Brothers and is loosely based on a 1975 film of the same name. It is expected to be another comedy hit from the duo known for films like There's Something About Mary and Dumb and Dumber.
Mapa Coonceptual Jean piaget
El documento describe las etapas del desarrollo de la inteligencia y la adquisición del lenguaje según Jean Piaget, incluyendo la etapa sensoriomotora desde los 0 a los 2 años, la preoperacional desde los 2 a los 7 años, las operaciones concretas desde los 7 a los 12 años y las operaciones formales desde los 12 a los 15 años. Cada etapa se caracteriza por diferentes habilidades lingüísticas y cognitivas.
Tudo sobre investimentos
Estudo deenvolvida pela Cyrela indicando principais pontos que justificam investimento em imoveis.
cam lqm 1082 g 919
This document is a marksheet for a Quranic Language Department course in the 2011/2012 semester. It lists 21 students with their matriculation numbers and names. It provides their marks for midterm exams, quizzes, oral exams, activities, and final exams, which are combined for a grand total out of 100. Most students received grades of C, D, or E, with scores ranging from 35 to 54 out of 100.
Writing
The document outlines the pre-writing and writing stages of composing a paragraph. In the pre-writing stage, writers collect facts, develop ideas, and identify the main idea. The writing stage involves organizing ideas into sentences, paragraphs, and parts. Paragraphs follow a basic structure, including a topic sentence, supporting details, and a concluding sentence.
Charla de violencia familiar
La charla sobre violencia familiar en Mahates buscó mejorar la convivencia en el hogar a través de una charla dirigida por el psicólogo de la alcaldía municipal el 11 de abril de 2012 sobre la violencia intrafamiliar.
Introduccion
Este documento introduce un estudio sobre la baja disponibilidad de medicamentos vitales no disponibles en la IPS Proinsalud de San Juan de Pasto, Colombia. Explica que aunque estos medicamentos son usados para tratar enfermedades raras, su acceso es dispendioso debido a los altos costos y trámites requeridos para su adquisición, además del bajo potencial del mercado colombiano que no es atractivo para compañías multinacionales. El estudio utilizará entrevistas con médicos, químicos farmacéuticos
Investigación ( 4 )
La profesora organizó a los estudiantes en equipos de trabajo según el tipo de contaminación sobre el que querían trabajar en su proyecto. Ella explicó nuevamente el objetivo del proyecto y pasó por cada mesa para corregir y aclarar dudas sobre cómo formular el objetivo. No hubo recursos ni evaluaciones durante la clase, solo se reforzó la redacción del objetivo del proyecto que habían iniciado la semana anterior.
8682111023368338mail
Upload your existing presentations, documents, videos, pdfs etc.
(Note: Our bulk uploader below lets you upload multiple files in one go)
Aceptacion
La aceptación debe manifestarse de forma expresa o tácita para que haya un acuerdo contractual. La aceptación solo concurre cuando es conforme con todos los elementos de la oferta original. Si hay cualquier modificación o desacuerdo, incluso sobre una cláusula secundaria, se considera una nueva oferta en lugar de una aceptación. La aceptación debe comunicarse al proponente dentro del plazo de validez de la oferta original para que se formalice el contrato.
Herramientas informaticas 1
La profesora se llama Luz Duran y la estudiante es Leidy Hernández Rojas.
Are Date ?
Dates contain many vitamins, minerals, and antioxidants that provide health benefits. However, dates also contain a high amount of natural sugars and have a high glycemic index, which can cause blood sugar levels to spike. While dates can be a healthy substitute for sweets if consumed in moderation, their high glycemic properties are associated with potential weight gain. Dates are best consumed in small portions and as part of an overall healthy diet low in refined carbs and sugars.
Seis sombreros para pensar.
El documento describe la técnica de los "Seis Sombreros para Pensar", la cual propone usar seis sombreros metafóricos (hechos de diferentes colores) para representar seis modos distintos de pensamiento: acción, emoción, forma, desempeño, juicio y aprendizaje. El objetivo es enseñar a las personas a pensar de manera más estructurada y completa antes de hablar o tomar decisiones.
Howard White Recommendation
Dr. Adams is a widely respected carbonate sedimentologist within Anadarko's Technology Group. He has provided critical analysis that has greatly assisted exploration and development teams in their successful programs. Adams has extensive knowledge of geology while specializing in carbonate sedimentology and diagenesis. He is able to convey reservoir observations to teams using his skills as a presenter. Adams has served as both an adviser and technical leader within Anadarko, and his leadership skills and technical advice were sought on several occasions for complicated carbonate reservoirs.
Molecular tools for pet of human depression ok 080513
Three studies examined serotonin transporter binding in major depressive disorder using PET. Two found lower binding and one found higher binding in depressed patients compared to controls. Two other studies found higher binding in depression. Bhagwagar et al. found no difference between recovered depressed patients and controls.
Cannon et al. found significantly higher serotonin transporter binding in the brains of patients with major depressive disorder compared to bipolar disorder patients and healthy controls using [11C]DASB PET.
Meltzer et al. found paradoxically that lower serotonin 1A receptor binding potential in the dorsal raphe nucleus was associated with more severe depression and slower treatment response in late-life depressed patients. Closer examination showed a positive
Psychotherapy the biological dimension
is it real word can affect your brain?
many people say not and don't believe that the psychotherapy change not only our behavior but also it can change the brain structure
Main
neural mechanisms to predict subjective level of fatigue in the futur: a magnetoencephalography study
Consortium_Poster
This study examined the association between increased fasting blood serum glucose levels and reduced default mode network connectivity in cognitively normal elderly subjects. The study found that higher glucose levels were negatively associated with connectivity in regions of the default mode network, including the hippocampus, parahippocampal formation, and fusiform gyrus. This negative association was seen in subjects regardless of their ApoE genotype. The results demonstrate that elevated glucose levels are negatively associated with default mode network connectivity and may increase risk for Alzheimer's disease.
An inhibitory pull–push circuit in frontal cortex
Push–pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull–push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull–push influence on excitatory neurons—an inversion of the canonical push–pull of feedforward input.
Yoga
The document summarizes two experiments that evaluated the effects of meditation on the central and autonomic nervous systems. In Experiment 1, brain imaging and physiological measures were taken before and after 5 days of meditation. Experiment 2 measured EEG and physiological responses. Both found lower skin conductance, increased breathing amplitude, and higher heart rate variability after meditation, indicating reduced sympathetic and increased parasympathetic activity. Experiment 1 also found increased theta brain wave activity in frontal regions. The results suggest meditation promotes relaxation of the body and mind through improved autonomic nervous system regulation with less effort.
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...BARRY STANLEY 2 fasd
IMPORTANCE Research to date has not determined a safe level of alcohol or tobacco use during pregnancy. Electroencephalography (EEG) is a noninvasive measure of cortical function that has previously been used to examine effects of in utero exposures and associations with
neurodevelopment.
OBJECTIVE To examine the association of prenatal exposure to alcohol (PAE) and tobacco smoking (PTE) with brain activity in newborns.
CONCLUSIONS AND RELEVANCE These findings suggest that even low levels of PAE or PTE are
associated with changes in offspring brain development.mapping functional brain activation using iodoantipyrine in male serotonin tr...
This study used functional brain mapping with [14C]-iodoantipyrine to examine regional cerebral blood flow (rCBF) in serotonin transporter knockout (KO) mice and wild-type (WT) mice during fear conditioning recall. The following key findings were reported:
1) During recall, KO mice showed increased freezing and rCBF in the amygdala compared to WT mice. KO mice also showed decreased rCBF in the hippocampus.
2) Conditioning increased rCBF in the amygdala and hippocampus in both genotypes. It decreased rCBF in somatosensory and motor cortices.
3) There were genotype differences in rCBF responses to conditioning in prefrontal
More Related Content
Viewers also liked
Writing
The document outlines the pre-writing and writing stages of composing a paragraph. In the pre-writing stage, writers collect facts, develop ideas, and identify the main idea. The writing stage involves organizing ideas into sentences, paragraphs, and parts. Paragraphs follow a basic structure, including a topic sentence, supporting details, and a concluding sentence.
Charla de violencia familiar
La charla sobre violencia familiar en Mahates buscó mejorar la convivencia en el hogar a través de una charla dirigida por el psicólogo de la alcaldía municipal el 11 de abril de 2012 sobre la violencia intrafamiliar.
Introduccion
Este documento introduce un estudio sobre la baja disponibilidad de medicamentos vitales no disponibles en la IPS Proinsalud de San Juan de Pasto, Colombia. Explica que aunque estos medicamentos son usados para tratar enfermedades raras, su acceso es dispendioso debido a los altos costos y trámites requeridos para su adquisición, además del bajo potencial del mercado colombiano que no es atractivo para compañías multinacionales. El estudio utilizará entrevistas con médicos, químicos farmacéuticos
Investigación ( 4 )
La profesora organizó a los estudiantes en equipos de trabajo según el tipo de contaminación sobre el que querían trabajar en su proyecto. Ella explicó nuevamente el objetivo del proyecto y pasó por cada mesa para corregir y aclarar dudas sobre cómo formular el objetivo. No hubo recursos ni evaluaciones durante la clase, solo se reforzó la redacción del objetivo del proyecto que habían iniciado la semana anterior.
8682111023368338mail
Upload your existing presentations, documents, videos, pdfs etc.
(Note: Our bulk uploader below lets you upload multiple files in one go)
Aceptacion
La aceptación debe manifestarse de forma expresa o tácita para que haya un acuerdo contractual. La aceptación solo concurre cuando es conforme con todos los elementos de la oferta original. Si hay cualquier modificación o desacuerdo, incluso sobre una cláusula secundaria, se considera una nueva oferta en lugar de una aceptación. La aceptación debe comunicarse al proponente dentro del plazo de validez de la oferta original para que se formalice el contrato.
Herramientas informaticas 1
La profesora se llama Luz Duran y la estudiante es Leidy Hernández Rojas.
Are Date ?
Dates contain many vitamins, minerals, and antioxidants that provide health benefits. However, dates also contain a high amount of natural sugars and have a high glycemic index, which can cause blood sugar levels to spike. While dates can be a healthy substitute for sweets if consumed in moderation, their high glycemic properties are associated with potential weight gain. Dates are best consumed in small portions and as part of an overall healthy diet low in refined carbs and sugars.
Seis sombreros para pensar.
El documento describe la técnica de los "Seis Sombreros para Pensar", la cual propone usar seis sombreros metafóricos (hechos de diferentes colores) para representar seis modos distintos de pensamiento: acción, emoción, forma, desempeño, juicio y aprendizaje. El objetivo es enseñar a las personas a pensar de manera más estructurada y completa antes de hablar o tomar decisiones.
Howard White Recommendation
Dr. Adams is a widely respected carbonate sedimentologist within Anadarko's Technology Group. He has provided critical analysis that has greatly assisted exploration and development teams in their successful programs. Adams has extensive knowledge of geology while specializing in carbonate sedimentology and diagenesis. He is able to convey reservoir observations to teams using his skills as a presenter. Adams has served as both an adviser and technical leader within Anadarko, and his leadership skills and technical advice were sought on several occasions for complicated carbonate reservoirs.
Viewers also liked (14)
Similar to Apss2010 abstract
Molecular tools for pet of human depression ok 080513
Three studies examined serotonin transporter binding in major depressive disorder using PET. Two found lower binding and one found higher binding in depressed patients compared to controls. Two other studies found higher binding in depression. Bhagwagar et al. found no difference between recovered depressed patients and controls.
Cannon et al. found significantly higher serotonin transporter binding in the brains of patients with major depressive disorder compared to bipolar disorder patients and healthy controls using [11C]DASB PET.
Meltzer et al. found paradoxically that lower serotonin 1A receptor binding potential in the dorsal raphe nucleus was associated with more severe depression and slower treatment response in late-life depressed patients. Closer examination showed a positive
Psychotherapy the biological dimension
is it real word can affect your brain?
many people say not and don't believe that the psychotherapy change not only our behavior but also it can change the brain structure
Main
neural mechanisms to predict subjective level of fatigue in the futur: a magnetoencephalography study
Consortium_Poster
This study examined the association between increased fasting blood serum glucose levels and reduced default mode network connectivity in cognitively normal elderly subjects. The study found that higher glucose levels were negatively associated with connectivity in regions of the default mode network, including the hippocampus, parahippocampal formation, and fusiform gyrus. This negative association was seen in subjects regardless of their ApoE genotype. The results demonstrate that elevated glucose levels are negatively associated with default mode network connectivity and may increase risk for Alzheimer's disease.
An inhibitory pull–push circuit in frontal cortex
Push–pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull–push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull–push influence on excitatory neurons—an inversion of the canonical push–pull of feedforward input.
Yoga
The document summarizes two experiments that evaluated the effects of meditation on the central and autonomic nervous systems. In Experiment 1, brain imaging and physiological measures were taken before and after 5 days of meditation. Experiment 2 measured EEG and physiological responses. Both found lower skin conductance, increased breathing amplitude, and higher heart rate variability after meditation, indicating reduced sympathetic and increased parasympathetic activity. Experiment 1 also found increased theta brain wave activity in frontal regions. The results suggest meditation promotes relaxation of the body and mind through improved autonomic nervous system regulation with less effort.
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...BARRY STANLEY 2 fasd
IMPORTANCE Research to date has not determined a safe level of alcohol or tobacco use during pregnancy. Electroencephalography (EEG) is a noninvasive measure of cortical function that has previously been used to examine effects of in utero exposures and associations with
neurodevelopment.
OBJECTIVE To examine the association of prenatal exposure to alcohol (PAE) and tobacco smoking (PTE) with brain activity in newborns.
CONCLUSIONS AND RELEVANCE These findings suggest that even low levels of PAE or PTE are
associated with changes in offspring brain development.mapping functional brain activation using iodoantipyrine in male serotonin tr...
This study used functional brain mapping with [14C]-iodoantipyrine to examine regional cerebral blood flow (rCBF) in serotonin transporter knockout (KO) mice and wild-type (WT) mice during fear conditioning recall. The following key findings were reported:
1) During recall, KO mice showed increased freezing and rCBF in the amygdala compared to WT mice. KO mice also showed decreased rCBF in the hippocampus.
2) Conditioning increased rCBF in the amygdala and hippocampus in both genotypes. It decreased rCBF in somatosensory and motor cortices.
3) There were genotype differences in rCBF responses to conditioning in prefrontal
Poster: Resting state ph-fMRI after THC administration
This study used resting state functional magnetic resonance imaging (RS-fMRI) to examine the effects of delta-9-tetrahydrocannabinol (THC) on functional brain connectivity in 9 males. Participants received inhalations of 2, 6, or 10 mg of THC or a placebo in a randomized, double-blind, crossover design. THC decreased functional connectivity within predefined brain networks in a dose-dependent manner compared to placebo. Some of the decreases in connectivity correlated with self-reported feelings of being high. RS-fMRI demonstrated it can objectively measure dose-dependent changes in brain activity induced by THC without a task.
Paper
This study investigated differences in the density of nitric oxide synthase (NOS) interneurons in the striatum between individuals with Tourette Syndrome (TS) and normal controls (NC). Brain tissue from 5 TS and 5 NC individuals was stained using immunohistochemistry to label NOS interneurons. The staining procedure and a pilot study to determine the most effective antibody were described. Sections from each brain were analyzed under a microscope using the Optical Fractionator probe method to count and compare NOS interneuron densities in the caudate nucleus and putamen between groups. It was hypothesized that NOS interneuron density would be decreased in the striatum of individuals with TS.
Predicting effects of atomoxetine and citalopram in Parkinson's disease
This study developed predictive models to identify Parkinson's disease patients who are most likely to benefit from atomoxetine (a noradrenaline reuptake inhibitor) or citalopram (a serotonin reuptake inhibitor) treatments based on clinical and brain imaging data. A support vector machine approach achieved up to 85% accuracy in predicting treatment response based on factors like fractional anisotropy in white matter tracts, drug concentrations, disease severity measures, and brain activation patterns during a motor inhibition task. The clinical model could help with patient selection for future trials and treatment decisions, while the mechanistic model provides insights into noradrenergic and serotonergic systems involved in cognitive control.
Electrophysiology of Human Native Receptors in Neurological and Mental Disorders
Dr. Agenor Limon presents research integrating functional metrics with large anatomical, transcriptomic, and proteomic datasets to evaluate the relationship between synaptic E/I ratio and behavioral abnormalities across postmortem intervals and brain banks.
Alterations in synaptic function have been found in transcriptomic, genetic, and proteomic studies of neurological and mental disorders. Clinical and preclinical studies suggest that synaptic dysfunction and behavioral abnormalities in disorders like Alzheimer’s disease and schizophrenia may be mechanistically linked to the emergence of imbalances between excitatory (E) and inhibitory (I) receptors. However, until recently, the electrophysiological E/I synaptic ratio had only been measured in animal models.
Using pioneering methods developed in the lab including reactivation and microtransplantation of synaptic receptors from frozen human brains, Dr. Agenor Limon’s research team has obtained electrophysiological metrics of global synaptic E/I ratios in cortical brain regions of subjects that were affected by Alzheimer’s Disease and synaptic measurements in schizophrenia.
In this webinar, Dr. Agenor Limon will present recent research integrating functional metrics with large anatomical, transcriptomic, and proteomic datasets to evaluate the relationship between synaptic E/I ratio and behavioral abnormalities across postmortem intervals and brain banks.
Key Topics Include:
- Understand the global synaptic excitation to inhibition ratio between excitatory and inhibitory synaptic receptors determined from reactivated frozen human brain tissue
- Understand the relationship between electrophysiological metrics of receptor function and multi-omic data in neurodegenerative disorders
- Understand the role of deviations of the excitation to inhibition ratio with clinical presentation in Alzheimer’s disease
A disinhibitory microcircuit initiates critical period plasticity in the visu...
Earlysensoryexperienceinstructsthematurationofneuralcircuitry in the cortex1,2. This has been studied extensively in the primary visualcortex,inwhichlossofvisiontooneeyepermanentlydegrades corticalresponsivenesstothateye3,4,aphenomenonknownasocular dominance plasticity (ODP). Cortical inhibition mediates this process4–6,butthepreciseroleofspecificclassesofinhibitoryneurons in ODP is controversial. Here we report that evoked firing rates of binocular excitatory neurons in the primary visual cortex immediatelydropbyhalfwhenvisionisrestrictedtooneeye,butgradually return to normal over the followingtwenty-four hours, despite the fact that vision remains restricted to one eye. This restoration of binocular-like excitatory firing rates after monocular deprivation resultsfromarapid,althoughtransient,reductioninthefiringrates of fast-spiking, parvalbumin-positive (PV) interneurons, which in turncanbeattributedtoadecreaseinlocalexcitatorycircuitinput onto PV interneurons.This reduction in PV-cell-evoked responses after monocular lid suture is restricted to the critical period for ODPandappearstobenecessaryforsubsequentshiftsinexcitatory ODP. Pharmacologically enhancing inhibition at the time of sight deprivation blocks ODP and, conversely, pharmacogenetic reduction of PV cell firing rates can extend the critical period for ODP. Thesefindingsdefinethemicrocircuitchangesinitiatingcompetitive
plasticityduringcriticalperiodsofcorticaldevelopment.Moreover, they show that the restoration of evoked firing rates of layer 2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ODP.
A disinhibitory microcircuit initiates critical period plasticity in the visu...
Early sensory experience instructs the maturation of neural circuitry in the cortex1, 2. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye3, 4, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition mediates this process4, 5, 6, but the precise role of specific classes of inhibitory neurons in ODP is controversial. Here we report that evoked firing rates of binocular excitatory neurons in the primary visual cortex immediately drop by half when vision is restricted to one eye, but gradually return to normal over the following twenty-four hours, despite the fact that vision remains restricted to one eye. This restoration of binocular-like excitatory firing rates after monocular deprivation results from a rapid, although transient, reduction in the firing rates of fast-spiking, parvalbumin-positive (PV) interneurons, which in turn can be attributed to a decrease in local excitatory circuit input onto PV interneurons. This reduction in PV-cell-evoked responses after monocular lid suture is restricted to the critical period for ODP and appears to be necessary for subsequent shifts in excitatory ODP. Pharmacologically enhancing inhibition at the time of sight deprivation blocks ODP and, conversely, pharmacogenetic reduction of PV cell firing rates can extend the critical period for ODP. These findings define the microcircuit changes initiating competitive plasticity during critical periods of cortical development. Moreover, they show that the restoration of evoked firing rates of layer 2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ODP.
Apss2009 abstract
1) The study compared pre-sleep waking quantitative EEG (qEEG) activity in veterans with PTSD, adults with primary insomnia, and good sleepers, hypothesizing that the patient groups would show increased fast-frequency qEEG activity.
2) They found no significant differences in sigma or beta band power between the groups during waking EEG.
3) In the PTSD group only, increased beta power during pre-sleep wakefulness correlated positively with severity of PTSD, depression, and anxiety symptoms.
Neurobiology of depression
(a) Several brain areas have been found to have abnormal activity or structure in patients with major depressive disorder (MDD) compared to healthy controls, including the prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, and orbitofrontal cortex.
(b) Imaging studies have found both hypoactivity and hyperactivity in different areas, and treatment has been shown to help normalize some of these abnormalities.
(c) The prefrontal cortex and limbic system including the hippocampus and amygdala appear to be particularly involved, and their structural and functional connections may contribute to MDD.
fnsys-09-00015
This study used fMRI on awake rats to investigate the neural response to capsaicin-induced pain. Capsaicin was injected into the hindpaw of wild-type rats and TRPV1 knockout rats. Wild-type rats showed activation of brain regions involved in the pain pathway, emotion, and memory after capsaicin injection. TRPV1 knockout rats did not show this same activation pattern in response to capsaicin. However, formalin still activated pain regions in TRPV1 knockout rats. The results suggest capsaicin may have antinociceptive effects independent of TRPV1 signaling and that imaging pain responses in awake animals can provide insights into full pain perception.
fnsys-09-00015
This study used fMRI to investigate the neural circuits involved in capsaicin-induced pain in awake rats. Capsaicin was injected into the hindpaw of wild-type and TRPV1 knockout rats during scanning. In wild-type rats, capsaicin activated brain regions implicated in the pain pathway as well as regions involved in emotion and memory. Capsaicin did not elicit significant activation in TRPV1 knockout rats, as expected. However, formalin still activated some pain-related regions in knockouts, and capsaicin may have antinociceptive effects independent of TRPV1 signaling. This study demonstrates the potential for awake animal neuroimaging to inform our understanding of full
Adolescent brain 2
This study used MRI scans to examine brain development between adolescence and adulthood. The key findings were:
1) Brain maturation between adolescence and adulthood was distinct from earlier development and was localized primarily to frontal and striatal regions, with little change elsewhere.
2) Specifically, the study found significant reductions in gray matter in dorsal, medial, and lateral frontal regions as well as in striatal regions between adolescence and adulthood.
3) These regional patterns of brain maturation between adolescence and adulthood align with findings from post-mortem studies and cognitive development, as frontal and striatal regions continue developing functionally during this period.
Meccanismi neurofisiologici dei disturbi degli stati di coscienza
di Paolo M. Rossini
Clinica Neurologica, Università Cattolica, Policlinico . Gemelli, Roma
Convegno "Le neuroscienze incontrano le altre discipline"
Padova, Palazzo del Bo
5 maggio 2011
Il convegno è promosso dall’Università di Padova e dal Dipartimento di Psicologia generale della stessa università, con il sostegno della Fondazione Sigma Tau e della Fondazione Giannino Bassetti.
Similar to Apss2010 abstract (20)
Molecular tools for pet of human depression ok 080513
Molecular tools for pet of human depression ok 080513
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...
Association Between Prenatal Exposure to Alcohol and Tobacco and Neonatal Bra...
mapping functional brain activation using iodoantipyrine in male serotonin tr...
mapping functional brain activation using iodoantipyrine in male serotonin tr...
Poster: Resting state ph-fMRI after THC administration
Poster: Resting state ph-fMRI after THC administration
Predicting effects of atomoxetine and citalopram in Parkinson's disease
Predicting effects of atomoxetine and citalopram in Parkinson's disease
Electrophysiology of Human Native Receptors in Neurological and Mental Disorders
Electrophysiology of Human Native Receptors in Neurological and Mental Disorders
A disinhibitory microcircuit initiates critical period plasticity in the visu...
A disinhibitory microcircuit initiates critical period plasticity in the visu...
A disinhibitory microcircuit initiates critical period plasticity in the visu...
A disinhibitory microcircuit initiates critical period plasticity in the visu...
Meccanismi neurofisiologici dei disturbi degli stati di coscienza
Meccanismi neurofisiologici dei disturbi degli stati di coscienza
Recently uploaded
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...Pitangent Analytics & Technology Solutions Pvt. Ltd
Discover top-tier mobile app development services, offering innovative solutions for iOS and Android. Enhance your business with custom, user-friendly mobile applications.GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
Tomaz Bratanic
Graph ML and GenAI Expert - Neo4j
Astute Business Solutions | Oracle Cloud Partner |
Your goto partner for Oracle Cloud, PeopleSoft, E-Business Suite, and Ellucian Banner. We are a firm specialized in managed services and consulting.
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...Edge AI and Vision Alliance
For the full video of this presentation, please visit: https://www.edge-ai-vision.com/2024/06/temporal-event-neural-networks-a-more-efficient-alternative-to-the-transformer-a-presentation-from-brainchip/
Chris Jones, Director of Product Management at BrainChip , presents the “Temporal Event Neural Networks: A More Efficient Alternative to the Transformer” tutorial at the May 2024 Embedded Vision Summit.
The expansion of AI services necessitates enhanced computational capabilities on edge devices. Temporal Event Neural Networks (TENNs), developed by BrainChip, represent a novel and highly efficient state-space network. TENNs demonstrate exceptional proficiency in handling multi-dimensional streaming data, facilitating advancements in object detection, action recognition, speech enhancement and language model/sequence generation. Through the utilization of polynomial-based continuous convolutions, TENNs streamline models, expedite training processes and significantly diminish memory requirements, achieving notable reductions of up to 50x in parameters and 5,000x in energy consumption compared to prevailing methodologies like transformers.
Integration with BrainChip’s Akida neuromorphic hardware IP further enhances TENNs’ capabilities, enabling the realization of highly capable, portable and passively cooled edge devices. This presentation delves into the technical innovations underlying TENNs, presents real-world benchmarks, and elucidates how this cutting-edge approach is positioned to revolutionize edge AI across diverse applications.Apps Break Data
How information systems are built or acquired puts information, which is what they should be about, in a secondary place. Our language adapted accordingly, and we no longer talk about information systems but applications. Applications evolved in a way to break data into diverse fragments, tightly coupled with applications and expensive to integrate. The result is technical debt, which is re-paid by taking even bigger "loans", resulting in an ever-increasing technical debt. Software engineering and procurement practices work in sync with market forces to maintain this trend. This talk demonstrates how natural this situation is. The question is: can something be done to reverse the trend?
Main news related to the CCS TSI 2023 (2023/1695)
An English 🇬🇧 translation of a presentation to the speech I gave about the main changes brought by CCS TSI 2023 at the biggest Czech conference on Communications and signalling systems on Railways, which was held in Clarion Hotel Olomouc from 7th to 9th November 2023 (konferenceszt.cz). Attended by around 500 participants and 200 on-line followers.
The original Czech 🇨🇿 version of the presentation can be found here: https://www.slideshare.net/slideshow/hlavni-novinky-souvisejici-s-ccs-tsi-2023-2023-1695/269688092 .
The videorecording (in Czech) from the presentation is available here: https://youtu.be/WzjJWm4IyPk?si=SImb06tuXGb30BEH .
Fueling AI with Great Data with Airbyte Webinar
This talk will focus on how to collect data from a variety of sources, leveraging this data for RAG and other GenAI use cases, and finally charting your course to productionalization.
Choosing The Best AWS Service For Your Website + API.pptx
Have you ever been confused by the myriad of choices offered by AWS for hosting a website or an API?
Lambda, Elastic Beanstalk, Lightsail, Amplify, S3 (and more!) can each host websites + APIs. But which one should we choose?
Which one is cheapest? Which one is fastest? Which one will scale to meet our needs?
Join me in this session as we dive into each AWS hosting service to determine which one is best for your scenario and explain why!
What is an RPA CoE? Session 1 – CoE Vision
In the first session, we will review the organization's vision and how this has an impact on the COE Structure.
Topics covered:
• The role of a steering committee
• How do the organization’s priorities determine CoE Structure?
Speaker:
Chris Bolin, Senior Intelligent Automation Architect Anika Systems
HCL Notes and Domino License Cost Reduction in the World of DLAU
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-and-domino-license-cost-reduction-in-the-world-of-dlau/
The introduction of DLAU and the CCB & CCX licensing model caused quite a stir in the HCL community. As a Notes and Domino customer, you may have faced challenges with unexpected user counts and license costs. You probably have questions on how this new licensing approach works and how to benefit from it. Most importantly, you likely have budget constraints and want to save money where possible. Don’t worry, we can help with all of this!
We’ll show you how to fix common misconfigurations that cause higher-than-expected user counts, and how to identify accounts which you can deactivate to save money. There are also frequent patterns that can cause unnecessary cost, like using a person document instead of a mail-in for shared mailboxes. We’ll provide examples and solutions for those as well. And naturally we’ll explain the new licensing model.
Join HCL Ambassador Marc Thomas in this webinar with a special guest appearance from Franz Walder. It will give you the tools and know-how to stay on top of what is going on with Domino licensing. You will be able lower your cost through an optimized configuration and keep it low going forward.
These topics will be covered
- Reducing license cost by finding and fixing misconfigurations and superfluous accounts
- How do CCB and CCX licenses really work?
- Understanding the DLAU tool and how to best utilize it
- Tips for common problem areas, like team mailboxes, functional/test users, etc
- Practical examples and best practices to implement right away
June Patch Tuesday
Ivanti’s Patch Tuesday breakdown goes beyond patching your applications and brings you the intelligence and guidance needed to prioritize where to focus your attention first. Catch early analysis on our Ivanti blog, then join industry expert Chris Goettl for the Patch Tuesday Webinar Event. There we’ll do a deep dive into each of the bulletins and give guidance on the risks associated with the newly-identified vulnerabilities.
Driving Business Innovation: Latest Generative AI Advancements & Success Story
Are you ready to revolutionize how you handle data? Join us for a webinar where we’ll bring you up to speed with the latest advancements in Generative AI technology and discover how leveraging FME with tools from giants like Google Gemini, Amazon, and Microsoft OpenAI can supercharge your workflow efficiency.
During the hour, we’ll take you through:
Guest Speaker Segment with Hannah Barrington: Dive into the world of dynamic real estate marketing with Hannah, the Marketing Manager at Workspace Group. Hear firsthand how their team generates engaging descriptions for thousands of office units by integrating diverse data sources—from PDF floorplans to web pages—using FME transformers, like OpenAIVisionConnector and AnthropicVisionConnector. This use case will show you how GenAI can streamline content creation for marketing across the board.
Ollama Use Case: Learn how Scenario Specialist Dmitri Bagh has utilized Ollama within FME to input data, create custom models, and enhance security protocols. This segment will include demos to illustrate the full capabilities of FME in AI-driven processes.
Custom AI Models: Discover how to leverage FME to build personalized AI models using your data. Whether it’s populating a model with local data for added security or integrating public AI tools, find out how FME facilitates a versatile and secure approach to AI.
We’ll wrap up with a live Q&A session where you can engage with our experts on your specific use cases, and learn more about optimizing your data workflows with AI.
This webinar is ideal for professionals seeking to harness the power of AI within their data management systems while ensuring high levels of customization and security. Whether you're a novice or an expert, gain actionable insights and strategies to elevate your data processes. Join us to see how FME and AI can revolutionize how you work with data!
Monitoring and Managing Anomaly Detection on OpenShift.pdf
Monitoring and Managing Anomaly Detection on OpenShift
Overview
Dive into the world of anomaly detection on edge devices with our comprehensive hands-on tutorial. This SlideShare presentation will guide you through the entire process, from data collection and model training to edge deployment and real-time monitoring. Perfect for those looking to implement robust anomaly detection systems on resource-constrained IoT/edge devices.
Key Topics Covered
1. Introduction to Anomaly Detection
- Understand the fundamentals of anomaly detection and its importance in identifying unusual behavior or failures in systems.
2. Understanding Edge (IoT)
- Learn about edge computing and IoT, and how they enable real-time data processing and decision-making at the source.
3. What is ArgoCD?
- Discover ArgoCD, a declarative, GitOps continuous delivery tool for Kubernetes, and its role in deploying applications on edge devices.
4. Deployment Using ArgoCD for Edge Devices
- Step-by-step guide on deploying anomaly detection models on edge devices using ArgoCD.
5. Introduction to Apache Kafka and S3
- Explore Apache Kafka for real-time data streaming and Amazon S3 for scalable storage solutions.
6. Viewing Kafka Messages in the Data Lake
- Learn how to view and analyze Kafka messages stored in a data lake for better insights.
7. What is Prometheus?
- Get to know Prometheus, an open-source monitoring and alerting toolkit, and its application in monitoring edge devices.
8. Monitoring Application Metrics with Prometheus
- Detailed instructions on setting up Prometheus to monitor the performance and health of your anomaly detection system.
9. What is Camel K?
- Introduction to Camel K, a lightweight integration framework built on Apache Camel, designed for Kubernetes.
10. Configuring Camel K Integrations for Data Pipelines
- Learn how to configure Camel K for seamless data pipeline integrations in your anomaly detection workflow.
11. What is a Jupyter Notebook?
- Overview of Jupyter Notebooks, an open-source web application for creating and sharing documents with live code, equations, visualizations, and narrative text.
12. Jupyter Notebooks with Code Examples
- Hands-on examples and code snippets in Jupyter Notebooks to help you implement and test anomaly detection models.
GNSS spoofing via SDR (Criptored Talks 2024)
In the realm of cybersecurity, offensive security practices act as a critical shield. By simulating real-world attacks in a controlled environment, these techniques expose vulnerabilities before malicious actors can exploit them. This proactive approach allows manufacturers to identify and fix weaknesses, significantly enhancing system security.
This presentation delves into the development of a system designed to mimic Galileo's Open Service signal using software-defined radio (SDR) technology. We'll begin with a foundational overview of both Global Navigation Satellite Systems (GNSS) and the intricacies of digital signal processing.
The presentation culminates in a live demonstration. We'll showcase the manipulation of Galileo's Open Service pilot signal, simulating an attack on various software and hardware systems. This practical demonstration serves to highlight the potential consequences of unaddressed vulnerabilities, emphasizing the importance of offensive security practices in safeguarding critical infrastructure.
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
At this talk we will discuss DDoS protection tools and best practices, discuss network architectures and what AWS has to offer. Also, we will look into one of the largest DDoS attacks on Ukrainian infrastructure that happened in February 2022. We'll see, what techniques helped to keep the web resources available for Ukrainians and how AWS improved DDoS protection for all customers based on Ukraine experience
AppSec PNW: Android and iOS Application Security with MobSF
Mobile Security Framework - MobSF is a free and open source automated mobile application security testing environment designed to help security engineers, researchers, developers, and penetration testers to identify security vulnerabilities, malicious behaviours and privacy concerns in mobile applications using static and dynamic analysis. It supports all the popular mobile application binaries and source code formats built for Android and iOS devices. In addition to automated security assessment, it also offers an interactive testing environment to build and execute scenario based test/fuzz cases against the application.
This talk covers:
Using MobSF for static analysis of mobile applications.
Interactive dynamic security assessment of Android and iOS applications.
Solving Mobile app CTF challenges.
Reverse engineering and runtime analysis of Mobile malware.
How to shift left and integrate MobSF/mobsfscan SAST and DAST in your build pipeline.
The Microsoft 365 Migration Tutorial For Beginner.pptx
This presentation will help you understand the power of Microsoft 365. However, we have mentioned every productivity app included in Office 365. Additionally, we have suggested the migration situation related to Office 365 and how we can help you.
You can also read: https://www.systoolsgroup.com/updates/office-365-tenant-to-tenant-migration-step-by-step-complete-guide/
Generating privacy-protected synthetic data using Secludy and Milvus
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
Artificial Intelligence and Electronic Warfare
Artificial Intelligence and Electronic WarfarePapadakis K.-Cyber-Information Warfare Analyst & Cyber Defense/Security Consultant-Hellenic MoD
AI & Electronic WarfareRecently uploaded (20)
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Crafting Excellence: A Comprehensive Guide to iOS Mobile App Development Serv...
Nordic Marketo Engage User Group_June 13_ 2024.pptx
Nordic Marketo Engage User Group_June 13_ 2024.pptx
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
GraphRAG for LifeSciences Hands-On with the Clinical Knowledge Graph
Astute Business Solutions | Oracle Cloud Partner |
Astute Business Solutions | Oracle Cloud Partner |
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...
“Temporal Event Neural Networks: A More Efficient Alternative to the Transfor...
Choosing The Best AWS Service For Your Website + API.pptx
Choosing The Best AWS Service For Your Website + API.pptx
HCL Notes and Domino License Cost Reduction in the World of DLAU
HCL Notes and Domino License Cost Reduction in the World of DLAU
Driving Business Innovation: Latest Generative AI Advancements & Success Story
Driving Business Innovation: Latest Generative AI Advancements & Success Story
Monitoring and Managing Anomaly Detection on OpenShift.pdf
Monitoring and Managing Anomaly Detection on OpenShift.pdf
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor Ivaniuk
AppSec PNW: Android and iOS Application Security with MobSF
AppSec PNW: Android and iOS Application Security with MobSF
The Microsoft 365 Migration Tutorial For Beginner.pptx
The Microsoft 365 Migration Tutorial For Beginner.pptx
Generating privacy-protected synthetic data using Secludy and Milvus
Generating privacy-protected synthetic data using Secludy and Milvus
Apss2010 abstract
- 1. The Relationship Between Absolute Beta Power and rCMRglc in Primary Insomnia during REM Sleep. Alman J, Miewald J, Cashmere D, Nofzinger E, Buysse DJ, Germain A Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States Introduction: Primary Insomnia (PI) is characterized by increased arousal and poor sleep. However, the neurobiological correlates of PI during REM sleep have been scarcely studied. We explored the relationship between whole-night absolute beta power during REM sleep and relative regional cerebral metabolic rate of glucose (rCMRglc) in adults with PI. Methods: Ten PI subjects (mean age 37.86±9.38 years) were included in this analysis. All were medication free and completed 3 nights of polysomnographic recordings and [18F]-fluoro-2-deoxy-D-glucose positron emission tomography scans during REM sleep. Regression analyses were conducted to evaluate the correlations between whole-night REM sleep absolute power spectral values for beta2 activity (16-32 Hz) and rCMRglc. Results: No significant positive correlation between beta activity and rCMRglc during REM sleep was observed. Significant negative correlations between beta activity and rCMRglc during REM sleep were observed in three brain areas. The first area (x, y, z, coordinates: -10, 48, 10, Z=3.36, P=0.03) included the left inferior and middle frontal gyri and extended into cingulate gyrus. The largest area (x, y, z, coordinates: 52, -66, 14, Z=4.15, P<.001) encompassed the right inferior, middle, and superior temporal gyri and the fusiform gyrus, parahippocampal gyrus and hippocampus. Bilaterally, it also included the posterior cingulate, precuneus, and superior parietal lobule. The last area (x, y, z, coordinates: -34, -44, -20, Z=4.38, P=.04) included the left fusiform gyrus, superior, inferior, and middle temporal gyri. Conclusion: In adults with PI, decreased whole-night beta activity was associated with increased rCMRglc during REM sleep in the temporal and parietal cortices bilaterally and in the left frontal regions. Posterior brain regions have been related to quiet, resting states. Replication of these preliminary results in large samples is required. Support: This research was supported by the National Institutes of Health (MH053035; MH024652; MH66227; RR024153) and the Department of Defense (PT073961- W81XWH-07-PTSD-IIRA).