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aminoglycoside.docx
1. aminoglycoside, any of several natural and semisynthetic compounds that are used to treat bacterial
diseases.
The term aminoglycoside is derived from the chemical structure of these compounds, which are made
up of amino groups (―NH2) attached to glycosides (derivatives of sugar).
The first aminoglycoside, the antibiotic streptomycin, was discovered in 1943 by American biochemists
Selman Waksman, Albert Schatz, and Elizabeth Bugie, who isolated the compound from Streptomyces
griseus, a strain of soil bacteria.
Streptomycin was found to inhibit the growth of a variety of bacterial organisms, including the organism
that causes tuberculosis (Mycobacterium tuberculosis