Aiche 2008, Philadelphia

The document describes research on modeling synthetic genetic AND gates using computational modeling. It discusses two approaches to modeling - assisting with analysis and design, or describing existing system behavior. It then details the development of a model for a synthetic genetic AND gate using elementary chemical reactions and stochastic simulation. The model was able to capture experimental results but required refinements to account for promoter leakiness. Overall, modeling helped understand the genetic components and could be applied to larger designs.