(Adam) Y. Zhong - Principal Scientist

(Adam) Yuanzhen Zhong, PhD, Principal Scientist
adam.zhong.phd@gmail.com, (201) 895-9588, https://www.linkedin.com/in/adam-yuanzhen-zhong-b6b9201
-------------------------------------- Cover Letter -----------------------------------------------------------
Fort Lee, NJ 07024
Dear Sir/Madam,
I helped companies develop new formulations/products/process/technologies in pharmaceutical,
cosmetic, beverage, and polymer industries, by utilizing my enormous expertise and hands-on
experience of formulation, raw materials, delivery technology, as well as management ability,
communication skills and business/marketing knowledge. Now I am eager to continue making
contributions at your company.
• Ph. D. in Physical Chemistry of Polymers
• Most recent position: MonoSol Rx, Principal Scientist, new pharmaceutical oral film
(PharmFilm®, thin film) product formulation and development (formulation and excipients
are similar to solid oral dosage products), 2012-06 to 2015-10.
• Previous positions:
o Hartz Mountain, Sr. Scientist, new animal health product formulation and development
(similar to cosmetic products), 2006-04 to 2012-03
o PepsiCo, Principal Scientist, new beverage flavor oil delivery technology development,
2002-09 to 2006-04
o L'Oreal, Sr. Scientist, new cosmetic product formulation and development, 2001-01 to
2003-06
o International Specialty Products (ISP), Group Leader and Research Scientist, new
polymer synthesis and application development, 1990-2000
• Technical expertise, experience, and demonstrated rack records:
o Unique knowledge and hands-on experience of both ingredients and consumer product
(pharmaceutical, cosmetic and beverage) formulation
o Pharmaceutical experience from R&D laboratory batches to production
o Expert in delivery systems and controlled-release technology, including surface science,
surfactant, emulsion, microemulsion, encapsulation, micro encapsulation, coacervation,
rheology, hot melt extrusion (HME), fluidized bed, resinate, cyclodextrin, resinate,
hydrogel, etc.
o New polymer synthesis and application development
o Identify and introduce new polymers into consumer product formulation
o Introduce and develop new technologies and solve technical problems in a timely fashion
o Experience of working with contract manufacturers
• Official training and practice of SOP, GMP, GCP, etc.
• Management experience and ability:
o Official training and practice Program and Project Management and Project and Gate
Process
o Supervise scientists
• Excellent communication skills including oral, writing, and presentation
Page 1 of 17

• Productive scientist with more than 30 publications, including 18 U.S. and international
patents
• MBA majoring in finance
• Adjunct Professor of Physical Chemistry at Pace University, New York.
Attached please find my resume and publication list. I would appreciate it if you could kindly
review my application and give me a favorable consideration. I am available immediately.
Thank you very much for your help.
Best wishes.
Sincerely,
(Adam) Yuanzhen Zhong, Ph.D.
(Phone) (201) 895-9588
E-Mail: adam.zhong.phd@gmail.com
LinkedIn URL: https://www.linkedin.com/in/adam-yuanzhen-zhong-b6b9201
------------------------------------------- Resume ------------------------------------------------------------
(Adam) Yuanzhen Zhong
(US Citizen)
309 McCloud Drive, Fort Lee, New Jersey 07024
E-Mail: adam.zhong.phd@gmail.com
Professional Summary
I helped companies develop new formulations/products/process/technologies in pharmaceutical,
cosmetic, beverage, and polymer industries, by utilizing my enormous expertise and hands-on
experience of formulation, raw materials, delivery technology, as well as management ability,
communication skills and business/marketing knowledge. Now I am eager to continue making
contributions at your company.
• Ph. D. in Physical Chemistry of Polymers
• Most recent position: MonoSol Rx, Principal Scientist, new pharmaceutical oral film
(PharmFilm®, thin film) product formulation and development (formulation and excipients
are similar to solid oral dosage products), 2012-06 to 2015-10.
• Previous positions:
o Hartz Mountain, Sr. Scientist, new animal health product formulation and development
(similar to cosmetic products), 2006-04 to 2012-03
o PepsiCo, Principal Scientist, new beverage product formulation product development
with emphasis on new delivery systems, 2002-09 to 2006-04
o L'Oreal, Sr. Scientist, new cosmetic product formulation and development, 2001-01 to
2003-06
Page 2 of 17

o International Specialty Products (ISP), Group Leader and Research Scientist, new
polymer synthesis and application development, 1990-2000
• Technical expertise, experience, and demonstrated rack records:
o Unique knowledge and hands-on experience of both ingredients and a consumer product
(pharmaceutical, cosmetic and beverage) formulation
o Pharmaceutical experience from R&D laboratory batches to production
o Expert in delivery systems and controlled-release technology, including Surface science,
surfactant, emulsion, micro emulsion, encapsulation, micro encapsulation, coacervation,
rheology, hot melt extrusion (HME), fluidized bed, resinate, cyclodextrin, resinate,
hydrogel, etc.
o New polymer product synthesis and application development
o Identify and introduce new polymers into consumer product formulation
o Introduce and develop new technologies and solve technical problems in a timely fashion
o Experience of working with contract manufacturers
• Official training and intensive application of SOP, GMP, GCP, etc.
• Management experience and ability:
o Official training and practice Program and Project Management and Project and Gate
Process
o Supervise scientists
• Excellent communication skills including oral, writing, and presentation
• Productive scientist with more than 30 publications, including 18 U.S. and international
patents
• MBA majoring in finance
• Adjunct Professor of Physical Chemistry at Pace University, New York.
Professional Career and Experience
MonoSol Rx, 30 Technology Drive, Warren, NJ 07059, USA, 06/25/2012 to 10/13/2015
Principal Scientist
Major Accomplishes:
• Successfully developed several new pharmaceutical thin film formulations, products and
process, including controlled substances (CII, CIII, CIV and CV) and potent compounds
• Thin film formulation and excipients are similar to solid oral dosage products
• The most significant completed and published project was Sildenafil (trade name:
Viagra) Oral Soluble Film
o From lab scale batches, to lab scale up trials, to process optimization batch, to
pivotal/exhibit/submission batch, to GMP clinical batch
o Clinical study showed excellent bioequivalence (BE) in comparison with Viagra
Oral tablets.
o Abstract and poster were published at 2015 AAPS Conference (Orlando), in titled
of “Bioequivalence of 2 Formulations of Sildenafil Oral Soluble Film 100 mg and
Sildenafil Citrate (Viagra) 100 mg Oral Tablets in Healthy Male Volunteers”
• Completed several internal and external technology transfer projects
o Internal technology transfer: Fluidized bed, delivery technology for controlled
release. Transferred from company old R&D in Indiana to new R&D in NJ
Page 3 of 17

o External technology transfer: Hot melt extrusion (HME), delivery technology for
controlled release. Transferred from contractor to company
• Introduced several delivery technology into thin film process
o Hot melt exclusion, Fluidized bed, Resinate, Cyclodextrine
• Experience of working with contract manufacturers
• Introduced several polymers into thin film and improve the
properties
o Introduced new polymers as thin film primary film-form
 Pullulan: Rapid dissolution rate. First applied in Sildenafil thin film, then to other
new thin film products. Patent application is underway
 Polyvinyl Alcohol (PVOH): Rapid dissolution rate as well as excellent properties.
First allied in Riluzole thin film.
o Identified polymers as disintegrator:
 Compared the disintegration rate of four polymers reported as disintegration
enhancers in literatures
 Corn starch, Sodium CMC, Alginate, Pullulan. Corn Starch was the best.
• Followed all regulations and guidelines of FDU, DEA, controlled substances, GMP (Good
Manufacturing Practice), GCP (Good Clinical Practice) SOP (Standard Operation
Procedure), safety, ICH (International Conference on Harmonisation of Technical
Requirements for Registration of Pharmaceuticals for Human Use), etc.
Major Duties:
• Develop pharmaceutical thin film formulations and products
• Introduce new technologies, process and polymers into thin film
• Follow all pharmaceutical regulations and guidelines
• Advise colleagues on polymer applications in thin film formulation
Hartz Mountain Corporation, 400 Plaza Drive, Secaucus, NJ 07094, USA, 04/10/2006 to
03/20/2012
Senior Scientist
Major Accomplishments:
• Successfully formulated and developed several new animal health products including
shampoos, sprays and conditioners (similar to human cosmetic products), as well as drops,
collars, tools, wipes, etc.
o Introduced new polymers to develop new animal self-warming shampoo products
o Introduced gel formulation technology and created new formulas to develop new
collar products containing controlled release and long term efficacy insecticide
• Conducted reformulation for cost reduction while maintaining the
same product high quality
• Advised colleagues on polymeric raw material applications in pet
product formulation
Major Duties:
• Formulated and develop new animal health products including shampoos, sprays and
conditioners (similar to human cosmetic products), as well as drops, collars, tools, wipes, etc.
• Conduct reformulation for cost reduction
Page 4 of 17

• Advise colleagues on polymer applications in pet product
formulation
PepsiCo, 100 Stevens Avenue, Valhalla, NY 10595, USA, 09/02/2002 to 12/08/2005
Principal Scientist, Project Leader
• Successfully developed several new beverage delivery systems
o Invented a new micro solubilization technology and developed phase diagram to
solubilize water-insoluble solid cooling flavor to launch a new products (7-Up Ice)
globally with annual sales > 2 million cases. U.S. and World Patents were issued.
o Applied micro emulsion as a new flavor delivery system to replace current
extraction approach to prepare beverage concentrates, with the huge cost savings up to
two thirds. U.S. and World Patents were issued.
o Developed micro emulsion Vitamins A and E formulas in Gatorade Propel
beverage to reduce the cost by more than half with annual saving of $400,000.
• Advised colleagues on polymeric raw material applications on
beverage formulation
Major Duties:
• Develop new beverage delivery systems for new product formulation and development
• Advise colleagues on polymeric raw material applications on beverage formulation
L'Oreal, 159 Terminal Avenue, Clark, NJ 07066, USA, 01/02/2001 to 03/14/2002
Senior Formulation Chemist
• Successfully formulated and developed several new Matrix Biolage brand hair products
including shampoo, conditioner, styling (aerosol and pump), etc.
o Introduced Styleze W-20 (INCI: Polyquaternium-55) to develop new shampoo
products with characteristics of hair fixative, conditioning, and curl retention against
humidity
o Introduced shape-memory polymer to develop new hair styling technology and
products, which made hair to be linear at higher temperature with less comb resistance
and to resume curly shape at room temperature
o Completed the project of preventing conditioner thickening effect during aging by
modified the emulsion formula and process. Fixed the problem in a timely fashion
o Contacted raw material suppliers on a regular basis via vendor meeting, vendor
presentation, trade show, etc., to identify new ingredients for new hair products
o Worked closely with other departments, including marketing, product evaluation
center (hair salon), claim lab, packaging, pilot plant, plant, etc., to conduct new projects,
evaluate the performance of new formulas, and push new products to market
• Advised colleagues on polymeric raw material applications in hair
product formulation
Major Duties:
• In charge of Matrix Biolage brand hair products, including shampoo, conditioner, styling
(aerosol and pump), etc.
• Advise colleagues on polymeric raw material applications in hair product formulation
Page 5 of 17

International Specialty Products (ISP), 1361 Alps Road, Wayne, NJ 07470, USA, 07/09/1990
to 12/31/2000
Group Leader, Research Scientist, Project Leader
• Developed innovative technologies in polymer synthesis:
o Created a mathematic model to control the monomer-feeding ratio during co-
polymerization, therefore generated copolymer with more homogeneous structure and
excellent solubility in water
o Applied the new co-polymerization technology on the manufacturing:
Polyvinylpyrrolidone and Vinyl Acetate copolymers (PVP/VA), several new products
were commercialized, the annual sales of PVP/VA copolymers were increased from $5
million to $20 million in 3 years
o Several US/international patents, articles, and presentations were published on
this topic
• Synthesis new polymers and created prototype formulas for
customers’ applications:
o New cationic hydrogel for hair and skin products (rheology
and hydrocolloid)
o Cross-linked PVP/VA for pharmaceutical controlled-
release
o PVP/MDO for bio-degradable material
o New cationic hydrogel for personal (hair and skin) care,
etc.
• Improved existing polymer product properties
o Reduced residual monomers from originally > 1% (10,000
ppm) to < 0.005% (50 ppm)
• Developed new polymer applications in the fields of pharmaceuticals, cosmetic,
agricultural, beverage, coating, adhesive, etc.
• Supervised a group of scientists
• Developed effective management skills: Monitored project progress on a regular basis,
including weekly reviews (in person), bi-weekly group meetings (lunch time or half-day),
monthly in writing, and summaries upon completion
• Developed excellent skills to communicate with R&D, manufacturing, and business (non-
technical) staff to complete the projects
• Excellent writing and presentation communication skills presented by more than 30
publications, including U.S. and international patents, articles, and presentations at ACS
(American Chemical Society) and international symposium
Major Duties:
• New polymer synthesis technology and product development
• New polymer characterization and application development
Education
Ph. D., Physical Chemistry of Polymers, Rutgers University, New Brunswick, NJ
1884 – 1990, GPA: 4.00/4.00
Advisor: Professor Ulrich P. Strauss, National Science Foundation Senior Fellow
Page 6 of 17

Research area: Physical chemistry of polymer solution, properties of water-soluble polymers,
polyelectrolyte solutions, surfactants, colloids, emulsions, and microemulsions.
Dissertation title: “Time-Resolved Luminescence Quenching Studies of Intramolecular
Micelles in Copolymers of Maleic Anhydride and Alkyl Ethers by a Single-Photon-Counting
Technique”
MBA, major in Finance, Fairleigh Dickinson University, Teaneck, NJ, May 2001
Part time, 1998 – 2001, GPA: Overall: 3.67/4.00; Major: 4.00/4.00
M. S., Polymer Chemistry, Zhongshan University, Guangzhou, Guangdong, P.R. China
GPA: 4.00/4.00, Advisor: Professor Zuomei Li
Research area: Polymer Physical Chemistry, solution properties of polyelectrolytes
Gained solid basis and hands-on experience of various approaches of polymerization, including
emulsion polymerization
Thesis title: “Studies on the Dilute Solution Behavior of 6,10-Inoene Polymer”
B. S., Chemistry, Jinan University, Guangzhou, Guangdong, P.R. China. GPA 4.00/4.00
Major Skills
• Formulation
• Excipient/Ingredient
• R&D Research
• Pharmaceutical formulation
• Thin film formulation
• Cosmetic formulation
• Beverage formulation
• Polymer synthesis
• Polymer application
• Polymer characterization
• Product innovation
• Process development
• Technology transfer
• Delivery technology
• Controlled release
• GMP, GCP, GXP
• FDA, EPA, DEA
• Controlled substance, Potent compound
• Regulatory affairs
• Validation
• Surface science, surfactants, phase diagram
Major Analytical and Instrumental Proficiency
Hands-on experience on many instruments, including:
Page 7 of 17

• Fluidized Bed
• Hot Melt Extrusion (HME)
• Texture analyzer (Textile strength, adhesive, etc.)
• Particle size analyzers (Horiba and Malvern)
• Surface tension measurement
• Optical microscope
• Fluorescence (dynamic and static)
• Light scattering (small-angle, multiply-angle, and laser)
• Spectroscopy (UV-Visible and IR)
• Chromatography (GC, GPC, and HPLC)
• Thermal analysis (Differential Thermal Analysis, DTA, etc.)
• Viscosity (capillary, Brookfield, Rheomat, etc.)
• Other routine and special measurements (turbidity on HACH, color on Hunter, etc.)
• Other routine and special operation procedures (freeze-drying, ultrasonic, homogenizer,
centrifuge, etc.)
• Various kinds of polymer synthesis equipments, including glass Buchan reactor provided by
a Sweden company and high pressure reactor
• Pharmaceutical thin film formulation and manufacturing equipments, including Renfert
degas/mixing system, Degus degas/mixing system, IKA MP-10 and MP-100, Mathis coater,
K-coater, Strike Die Puncher, Die Cutter Puncher, Fuji pulse pouch sealer
Affiliations
• American Chemical Society (ACS), and its Divisions (POLY and PMSE)
• American Association of Pharmaceutical Scientists (AAPS)
• Society of Cosmetic Chemists (SCC)
• Institute of Food Technologists (IFT)
• Bio/Environmental Degradable Polymer Society (BEDPS)
Honors and Awards
• Who’sWho in America, Who’sWho in the World, American Men & Women of Science,
Who’sWho in Science and Engineering
• PepsiCo R&D VP Award Nomination
• ISP New Pharmaceutical Product Award, ISP Executive Incentive Compensation, ISP
President’s Award
Patents, Articles, and Presentations
• Productive scientist with more than 30 patents, articles, and presentations
• Patents: 19 U.S., international, and world patents were issued
• Articles and presentations: 15 were published
Page 8 of 17

----------------------------------------------- Publication List ----------------------------------------------
U.S., international, and world patents (19 issued)
1. United States Patent 8,293,300 B2, Yuanzhen Zhong et al, “Anhydrous Flavor Delivery
Composition and Method”, Oct. 23, 2012;
URL:
https://www.google.com/patents/US8293300?dq=8,293,300&hl=en&sa=X&ei=-
nJrVInAJOLGsQTf74L4BA&ved=0CB0Q6AEwAA
Abstract:
An anhydrous flavor delivery composition comprising a water-insoluble component, a
surfactant and an alcohol is provided. In addition, a method of making the anhydrous flavor
delivery composition and a method of flavoring a beverage are provided.
2. United States Patent 7,402,327, Yuanzhen Zhong et al, “Use of Surfactants to Solubilize Water-
Insoluble Solids in Beverages”, July 22, 2008;
URL: https://www.google.com/patents/US7402327?
dq=7,402,327B2&hl=en&sa=X&ei=oHdrVNbTA9LGsQTIwoDACg&ved=0CB0Q6AEwAA
Abstract:
Surfactants are used in low concentrations in order to solubilize water insoluble solids for
inclusion in aqueous beverages. Beverage concentrates, beverage syrups and finished
beverages, all of which contain surfactant and water insoluble solids, are stable; the
concentrates and finished beverages are clear.
3. World Patent WO/2007/090142, Yuanzhen Zhong et al, “Anhydrous Flavor Delivery
Composition and Method”, 09 Aug 2007;
URL:
http://patentscope.wipo.int/search/en/detailPdf.jsf?
ia=US2007061353&docIdPdf=id00000005420611%3FparSeparator1=&name=WO200709014
2ANHYDROUS+FLAVOR+DELIVERY+COMPOSITION+AND+METHOD&parSeparator2
=&woNum=WO2007090142&prevRecNum=2&nextRecNum=4&recNum=2&queryString=A
LL%3A%28Zhong%2C+Yuanzhen
%29&office=&sortOption=Pub+Date+Desc&prevFilter=&maxRec=10
Abstract:
An anhydrous flavor delivery composition comprising a water-insoluble component, a
surfactant and an alcohol is provided. In addition, a method of making the anhydrous flavor
delivery composition and a method of flavoring a beverage are provided.
4. Chinese Patent CN1688213A, Yuanzhen Zhong et al, “表面活性剂溶解饮料中水不溶性固体的
用途”, Oct. 26, 2005;
URL: http://www.google.im/patents/CN1688213A?cl=fi
5. World Patent WO/2004/023900, Yuanzhen Zhong et al, “Use of Surfactants to Solubilize
Water-Insoluble Solids in Beverages”, 25 Mar 2004;
URL:
Page 9 of 17

0USE+OF+SURFACTANTS+TO+SOLUBILIZE+WATER-
INSOLUBLE+SOLIDS+IN+BEVERAGES&parSeparator2=&woNum=WO2004023900&pre
vRecNum=3&nextRecNum=5&recNum=3&queryString=ALL%3A%28Zhong
%2C+Yuanzhen%29&office=&sortOption=Pub+Date+Desc&prevFilter=&maxRec=10
Abstract:
Surfactants are used in low concentrations in order to solubilize water insoluble solids for
inclusion in aqueous beverages. Beverage concentrates, beverage syrups and finished
beverages, all of which contain surfactant and water insoluble solids, are stable; the
concentrates and finished beverages are clear.
6. United States Patent 6,667,029 B2, Yuanzhen Zhong, J. Jachowicz, P. Wolf, and R. Mc Mullen,
“Stable, Aqueous Cationic Hydrogel”, Dec. 23, 2003;
URL:
https://www.google.com/patents/US6667029?
dq=6,667,029&hl=en&sa=X&ei=MXhrVITgAcGBsQSn_ICwDA&ved=0CB0Q6AEwAA
Abstract:
A stable, aqueous cationic hydrogel of, by weight, 1-50% of a crosslinked cationic
copolymer of 5-95% vinylpyrrolidone (VP) and 5-95% 3-
dimethylaminopropyl(meth)acrylamide (DMAPMA) monomers, a crosslinking agent in an
amount of 0.05-1% of said monomers, and water is described. The hydrogel has a pH of
about 10 and a Brookfield viscosity of about 650 (Model DV-II+, RV spindle #3, speed 10
rpm); it can increase its viscosity by up to 40× at a pH of 3-9 and absorb up to 200× its
weight of water. The hydrogel also can effectively condition hair even in the presence of an
anionic surfactant.
7. World Patent WO/2001/003658, Yuanzhen Zhong et al, “Crosslinked Cationic Microgels,
Process for Making Same and Hair Care Compositions Therewith”, 18 Jan 2001;
URL:
http://patentscope.wipo.int/search/en/detailPdf.jsf?ia=US2000012858&docIdPdf=09006361800274ac
%3FparSeparator1=&name=WO2001003658CROSSLINKED+CATIONIC+MICROGELS
%2C+PROCESS+FOR+MAKING+SAME+AND+HAIR+CARE+COMPOSITIONS+THEREWITH&
parSeparator2=&woNum=WO2001003658&prevRecNum=4&nextRecNum=6&recNum=4&queryStrin
g=ALL%3A%28Zhong%2C+Yuanzhen
Abstract:
What is described herein is a fine particulate, crosslinked cationic microgel which is capable
of adsorbing up to 200 times its dry gel weight of water, and which has a viscosity of 5870
cps in water at a pH of 2.8 adjusted with a divalent or trivalent acid, at a copolymer
concentration of about 1 %. The microgel includes, by weight, about 5-95 %, preferably 50
% of a water soluble monomer which is vinyl pyrrolidone (VP), and about 5-95 %,
preferably 50 %, of a water soluble cationic monomer which is 3-dimethylaminopropyl-
(meth)acrylamide (DMAPMA) and a low crosslinker content, e.g. about 0.2 %. The
copolymers are made by a solution polymerization process from a mixture of VP and
DMAPMA, crosslinker, solvent and initiator. The invention also describes hair care
composition which include, by weight, about 0.01-5 % of such microgel polymers, and
Page 10 of 17

water, at a low pH, which exhibit conditioning and styling of the microgel copolymer and
water. In shampoo formulations, optionally an anionic surfactant is included.
8. United States Patent 5,912,312, Yuanzhen Zhong, P. Wolf, E. Malawer and K. Narayanan,
“Homogeneous copolymers containing vinyl pyrrolidone and 2-methylene-1,3-dioxepane and
process for making same”, June 15, 1999;
URL:
dq=5,912,312&hl=en&sa=X&ei=YnhrVNoh0cexBOKCgZAG&ved=0CB8Q6AEwAA
Abstract:
Homogeneous copolymers of 60-99 mole % of vinyl pyrrolidone (VP) and 1-40 mole % 2-
methylene-1,3-dioxepane (MDO), preferably 85-95 mole % VP and 5-10 mole % MDO, having
a K-value of about 30-50, and a Tg of about 124-138° C., are described herein. The copolymers
are hydrolytically degradable in aqueous acid or basic solutions and biodegradable.
9. United States Patent 5,684,105, Yuanzhen Zhong and P. Wolf, “Process for providing
homogeneous copolymers of vinylpyrrolidone and 3-dimethylaminopropyl methacrylamide
(DMAPMA) which form clear aqueous solutions having high cloud points”, November 4, 1997;
URL:
dq=5,684,105&hl=en&sa=X&ei=iXhrVPvWNujIsATttoCwCg&ved=0CB8Q6AEwAA
Abstract:
A process for making homogeneous copolymers of vinylpyrrolidone (VP) and 3-
dimethylaminopropyl methacrylamide (DMAPMA) which form clear aqueous solutions having
high cloud points. The process involves precharging VP and DMAPMA monomers in a
predetermined ratio, and then feeding VP and DMAPMA at a predetermined rate, the ratio of
the components in the initial charge and the feeding rates for the monomer being selected in
accordance with the reactivity rates of the monomers towards copolymerization as opposed to
homopolymerization.
10. United States Patent 5,663,258, Yuanzhen Zhong and P. Wolf, “Strongly swellable, moderately
crosslinked copolymers of vinylpyrrolidone and vinyl acetate”, September 2, 1997;
URL:
dq=5,663,258&hl=en&sa=X&ei=AXlrVJXWM7P-sASyoIKIBA&ved=0CB8Q6AEwAA
Abstract:
Strongly swellable, moderately crosslinked poly(vinyl pyrrolidone/vinyl acetate) copolymer
(XL-PVP/VA) in the form of fine, white powders characterized by (a) an aqueous gel volume of
about 15 to 150 ml/g of polymer, (b) a Brookfield viscosity in 5% aqueous solution of at least
about 10,000 cps, and (c) being prepared directly by precipitation polymerization of VP and VA
monomers in the presence of a crosslinking agent in the amount of about 0.1 to about 2% by
weight of VP and VA.
11. World Patent WO/1997/031041, Yuanzhen Zhong et al, “Strongly swellable, moderately
crosslinked copolymers of vinylpyrrolidone and vinyl acetate”, 28 Aug 1997;
URL:
Page 11 of 17

1STRONGLY+SWELLABLE%2C+MODERATELY+CROSS-
LINKED+COPOLYMERS+OF+VINYLPYRROLIDONE+AND+VINYL+ACETATE&parSe
parator2=&woNum=WO1997031041&prevRecNum=6&nextRecNum=8&recNum=6&querySt
ring=ALL%3A%28Zhong%2C+Yuanzhen
Abstract:
Strongly swellable, moderately cross-linked poly(vinyl)pyrrolidone/vinyl acetate) copolymer
(XL-PVP/VA) in the form of fine, white powders characterized by (a) an aqueous gel volume of
about 15 to 150 ml/g of polymer, (b) a Brookfield viscosity in 5 % aqueous solution of at least
about 10,000 cps, and (c) being prepared directly by precipitation polymerization of VP and VA
monomers in the presence of a cross-linking agent in the amount of about 0.1 to about 2 % by
weight of VP and VA.
12. United States Patent 5,604,275, Yuanzhen Zhong and P. Wolf, “Color stabilized aqueous n-
vinyl heterocyclic copolymer solution”, February 18, 1997;
URL:
dq=5,604,275&hl=en&sa=X&ei=V3lrVJiiAcvmsASN6oHwBQ&ved=0CB8Q6AEwAA
Abstract:
This invention relates to an N-vinyl heterocyclic copolymer in substantially pure deionized
water or in aqueous alcoholic solution which exhibits significantly reduced color and odor and
which is obtained by contacting an alcohol-copolymer mixture with water and a nitrogen
containing, trivalent boron complex compound selected from the group of borane-ammonia,
borane-lower alkylamine, tetra-lower alkyl ammonium octahydrotriborate, morpholine-borane,
lower alkyl morpholine-borane, silylamino borane and mixtures thereof and stripping alcohol
from the resulting mixture under vacuum at between about 100 and about 740 mm Hg below
absolute whereby an aqueous, 10-70 wt. % solids solution of the copolymer is obtained having a
water white color stability of more than a year.
13. World Patent WO/1996/018673, Yuanzhen Zhong et al, “Color stabilization of Aqueous
Heterocyclic Copolymer”, 20 Jun 1996;
URL:
3COLOR+STABILIZATION+OF+AQUEOUS+HETEROCYCLIC+COPOLYMER&parSepa
rator2=&woNum=WO1996018673&prevRecNum=7&nextRecNum=9&recNum=7&queryStri
ng=ALL%3A%28Zhong%2C+Yuanzhen
Abstract:
This invention relates to a process for the production of substantially odorless, color stable N-
vinyl heterocyclic copolymer which includes contacting alcohol solution of the copolymer,
under reduced pressure, with water and a reducing agent selected from the group of a nitrogen
containing borane complex, sulfurous acid and an alkali metal salt of sulfurous acid and
recovering an aqueous, 10-80 wt.% solids solution of the copolymer having a substantially color
free stability for a period of more than a year. The invention also relates to an N-vinyl
heterocyclic copolymer in substantially pure deionized water or in aqueous alcoholic solution
which exhibits significantly reduced color and odor and which is obtained by contacting an
Page 12 of 17

alcohol-copolymer mixture with water and a nitrogen containing, trivalent boron complex
compound and stripping alcohol from the resulting mixture.
14. United States Patent 5,534,564, Yuanzhen Zhong and P. Wolf, “Process for the color
stabilization of an aqueous n-vinyl heterocyclic copolymer solution”, July 9, 1996;
URL:
dq=5,534,564&hl=en&sa=X&ei=eXlrVMvcA7f_sASAvoGYDQ&ved=0CB8Q6AEwAA
Abstract:
This invention relates to a process for the production of a substantially odorless, color stable N-
vinyl heterocyclic copolymer in pure deionized water or in aqueous alcoholic solution which
includes contacting an alcohol solution of the copolymer, under reduced pressure, at alcohol
reflux temperature with water and a reducing agent selected from the group of a nitrogen
containing borane complex, sulfurous acid and/or an alkali metal salt of sulfurous acid and
recovering an aqueous, 10-80 wt. % solids solution of the copolymer having a substantially
color free stability for a period of more than a year.
15. World Patent WO/1995/015987, Yuanzhen Zhong et al, “Preparing Copolymers of
Vinylpyrrolidone and Vinyl Acetate”, 14 Mar 1995;
URL:
7PREPARING+COPOLYMERS+OF+VINYLPYRROLIDONE+AND+VINYL+ACETATE&
parSeparator2=&woNum=WO1995015987&prevRecNum=8&nextRecNum=10&recNum=8&
queryString=ALL%3A%28Zhong%2C+Yuanzhen
Abstract:
A process for making homogeneous copolymers of vinylpyrrolidone (VP) and vinyl acetate
(VA) which form clear aqueous solutions and have high cloud points. The process involves
precharging VP and VA monomers in a predetermined ratio, and then feeding VP and VA at a
predetermined rate, the ratio of the components in the initial charge and the feeding rates for the
monomer being selected in accordance with the reactivity rates of the monomers towards
copolymerization as opposed to homopolymerization.
16. United States Patent 5,502,136, Yuanzhen Zhong, P. Wolf and Y. Reuven, “Process of making
substantially homogeneous copolymers of vinyl pyrrolidone and vinyl acetate which form clear
aqueous solutions”, March 26, 1996;
URL:
dq=5,502,136&hl=en&sa=X&ei=ynlrVM70LMmKsQSFp4K4Dg&ved=0CB8Q6AEwAA
Abstract:
A process is described for making substantially homogeneous copolymers comprising 50-90%
of vinyl pyrrolidone (VP) and 10-50% of vinyl acetate (VA), by weight, which form clear
aqueous solutions.
17. United States Patent 5,395,904, Yuanzhen Zhong, H. Parikh, and T. Smith, “Process for
providing homogeneous copolymer of vinylpyrrolidone and vinyl acetate which form clear
aqueous solutions having a high cloud point”, March 7, 1995;
Page 13 of 17

URL:
dq=5,395,904&hl=en&sa=X&ei=73lrVLuNPIvIsQS5-4CQCg&ved=0CCIQ6AEwAA
Abstract:
A process for making homogeneous copolymers of vinylpyrrolidone (VP) and vinyl acetate
(VA) which form clear aqueous solutions and have high cloud points. The process involves
precharging VP and VA monomers in a predetermined ratio, and then feeding VP and VA at a
predetermined rate, the ratio of the components in the initial charge and the feeding rates for the
monomer being selected in accordance with the reactivity rates of the monomers towards
copolymerization as opposed to homopolymerization.
18. United States Patent 5,319,041, Yuanzhen Zhong, H. Parikh, P. Taylor and T. Smith, “Process
for the preparation of vinylpyrrolidone/vinyl acetate copolymers”, June 7, 1994;
URL:
dq=5,319,041&hl=en&sa=X&ei=D3prVPjtJvKZsQS4_IKYDw&ved=0CB8Q6AEwAA
Abstract:
This invention relates to an improved process for producing a clear solution of
vinylpyrrolidone (VP) and vinyl acetate (VA) monomers which comprises, in an anhydrous
system,
(a) reacting a C2 to C3 alcoholic solution containing said VA monomer and between about 60
and about 80 wt. % portion of total VP monomer in the presence of between about 0.05 and
about 0.3 wt. % of a free radical initiator selected from the group consisting of
tertamylperoxy pivalate and 2,2-azobis(2-methylbutyronitrile) or a mixture thereof for a
period of from about 5 to about 10 hours, at a temperature between about 60° and about 110°
C.;
(b) gradually adding the remaining VP monomer in C2 to C3 alcohol solution at reaction
temperature after the addition of the VA monomer is complete;
(c) raising the temperature of the resulting reaction mixture to between about 110° and about
150° C.;
(d) continuing the polymerization reaction at said higher temperature in the presence of from
about 0.11 to about 0.6 wt. %, based on total monomers, of 2,5-dimethyl-2,5-bis(tert-
butylperoxy) hexane and
(e) cooling the resulting reaction mixture and recovering a homogeneous VP/VA copolymer
C2 to C3 alcohol solution containing less than 100 ppm of residual vinylpyrrolidone monomer
or vinyl acetate residual monomer.
19. World Patent WO/1994/022923, Yuanzhen Zhong et al, “Process for the Preparation of
Vinylpyrrolidone and Vinyl Acetate Copolymers”, 14 Oct 1994;
URL:
3PROCESS+FOR+THE+PREPARATION+OF+VINYLPYRROLIDONE
%2FVINYL+ACETATE+COPOLYMERS&parSeparator2=&woNum=WO1994022923&prev
RecNum=9&nextRecNum=11&recNum=9&queryString=ALL%3A%28Zhong
%2C+Yuanzhen%29&office=&sortOption=Pub+Date+Desc&prevFilter=&maxRec=10
Abstract:
Page 14 of 17

This invention relates to an improved process for producing a clear solution of
vinylpyrrolidone (VP) and vinyl acetate (VA) monomers which comprises, in an anhydrous
system, (a) reacting a C2 to C3 alcoholic solution containing said VA monomer and between
about 60 and about 80 wt.% portion of total VP monomer in the presence of between about
0.05 and about 0.3 wt.% of a free radical initiator selected from the group consisting of tert-
amylperoxy pivalate and 2,2-azobis(2-methylbutyronitrile) or a mixture thereof for a period
of from about 5 to about 10 hours, at a temperature between about 60 and about 110 °C; (b)
gradually adding the remaining VP monomer in C2 to C3 alcohol solution at reaction
temperature after the addition of the VA monomer is complete; (c) raising the temperature of
the resulting reaction mixture to between about 110 and about 150 °C; (d) continuing the
polymerization reaction at said higher temperature in the presence of from about 0.11 to
about 0.6 wt.%, based on total monomers, of 2,5-dimethyl-2,5-bis(tert-butylperoxy) hexane
and (e) cooling the resulting reaction mixture and recovering a homogeneous VP/VA
copolymer C2 to C3 alcohol solution containing less than 100 ppm of residual
vinylpyrrolidone monomer or vinyl acetate residual monomer.
Articles, Abstracts, and Presentations (16 published)
1. Yuanzhen Zhong et al, “Bioequivalence of 2 Formulations of Sildenafil Oral Soluble Film
100 mg and Sildenafil Citrate (Viagra) 100 mg Oral Tablets in Healthy Male Volunteers”, AAPS
(American Association of Pharmaceutical Scientists) Abstract, Oct. 28, 2015. Description: Two
pharmaceutical oral soluble film formulation of sildenafil 100 mg were developed and compared to
sildenafil citrate (Viagra) in clinical study, and the results demonstrated bioequivalence of the
pharm films and tablet. In coupled with the advantages of rapid dissolution in mouth without water
and swallow, pharm film provides an attractive alternative to tablet.
URL: http://abstracts.aaps.org/Published/Browse.aspx?colID=32, AAPS2015-M1196
2. Yuanzhen Zhong and Janusz Jachowicz, “Hydrogel prepared from cationic copolymer - 2”,
Polymer Preprints, 2002, 43(1), pp. 553-554
3. Yuanzhen Zhong, Janusz Jachowicz, et al, “Hydrogel prepared from cationic copolymer”,
Polymer Preprints, 2000, 41(2), pp. 1136-1137
4. Yuanzhen Zhong, P. Wolf, E. “Effect of hydrophobic unit and its distribution on solution
properties of vinylpyrrolidone and vinyl acetate copolymer”, Journal of Applied Polymer
Science, Vol. 74, No. 2, pp. 345-352, Oct. 10, 1999.
URL:
http://onlinelibrary.wiley.com/doi/10.1002/%28SICI%291097-
4628%2819991010%2974:2%3C345::AID-APP16%3E3.0.CO;2-N/abstract
Abstract:
A series of vinyl pyrrolidone and vinyl acetate copolymers with different monomer ratios and
homogeneity in backbone distribution were synthesized and their solution properties studied.
In water, the phase diagram curve is concave, with the lower critical solution temperature,
due to the cooperation of hydrophobic and hydrophilic hydration. In order to make a
substantially homogeneous copolymer, a new method to determine the monomer mole
fraction is suggested. When the vinyl pyrrolidone to vinyl acetate mole ratio in the
copolymer is close to unity, sequence distribution plays an important part in solution
behavior. The more homogeneous the structure, the better the solubility in water, and the
Page 15 of 17

higher the cloud point. This is attributed to the balance between hydrophobic and hydrophilic
forces in solution. Copolymerization kinetic analysis on monomer conversions and turbidity
measurement on poly(vinylpyrrolidone/vinyl acetate) solutions give consistent results to
confirm this interpretation. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 345–352,
1999
5. Yuanzhen Zhong, P. Wolf, E. et al, “Swelling properties of crosslinked vinylpyrrolidone
homopolymers and vinylpyrrolidone/vinyl acetate copolymers”, Polymer Preprints, 1998, 39,
pp. 461-462
6. Yuanzhen Zhong, P. Wolf, E. et al, “Hydrolytic degradation properties of biodegradable
vinylpyrrolidone and 2-methylene-1,3-dioxepane copolymers”, 7th
Annual Meeting of the
Bio/Environmentally Degradable Polymer Society (BEDPS), 1998, p. 41
7. Yuanzhen Zhong and P. Wolf, “Hydrogel prepared from crosslinked vinyl pyrrolidone and
vinyl acetate copolymers”, Polymer Preprints, 1997, 38, pp. 578-579
8. Yuanzhen Zhong and P. Wolf, “Studies on synthesis and solution properties of vinyl
pyrrolidone and vinyl acetate copolymers, Book of Abstracts for the Fifth Eurasia Conference
on Chemical Science (Guangzhou, China, 1996), p.539.
9. Yuanzhen Zhong and P. Wolf, “Solution behavior of vinyl pyrrolidone and vinyl acetate
copolymers”, Polymer Preprints, 1995, 36, pp. 370-371
10. U.P. Strauss, Yuanzhen Zhong, et al, “ Determination of microdomain size of hydrophobic
polyelectrolytes by luminescence quenching”, in Macro-Ion Characterization, 1994, pp. 154-
161;
URL: http://pubs.acs.org/doi/pdf/10.1021/bk-1994-0548.ch012
Abstract:
The luminescence decay kinetics of a ruthenium complex solubilized by a hydrolyzed
copolymer of maleic anhydride and n-hexyl vinyl ether (DP 1100) were measured at different
pHs as a function of the concentration of quencher, 9-methyl anthracene, in order to
determine the size of the intramolecular micelles formed by the copolymer. The
solubilization of quencher was used to determine the degree of micellization of the
copolymer at various pHs. A time-resolved, single photon counting technique was employed
for the luminescence decay measurements. Results indicated that an average of 42 repeat
units comprised a micelle, indicating that one copolymer chain can form many
intramolecular micelles. The micelle size was independent of pH and quencher
concentration.
11. U.P. Strauss, Yuanzhen Zhong, et al, “Determination of microdomain size of hydrophobic
polyelectrolytes by luminescence quenching”, Polymer Preprints, 1993, 34, pp. 1026-1027.
12. Z. Li, Yuanzhen Zhong, et al, “Hydrophobic interactions of ionene in aqueous solution,
Macromolecules, 1992, 25, pp. 450-453.
Page 16 of 17

13. Yuanzhen Zhong, “Time-resolved luminescence quenching studies of intramolecular micelles in
copolymers of maleic anhydride and alkyl ethers by a single-photon-counting technique”,
Dissertation, 1990, Rutgers University, New Brunswick, NJ, 128 pages
URL:
http://books.google.com/books?id=VAHoGwAACAAJ&dq=inauthor:%22Yuanzhen+Zhong
%22&hl=en&sa=X&ei=IsFrVMr3JIevogT_5YK4DQ&ved=0CB8Q6AEwAA
Abstract:
The intramolecular micellar properties of the alternating copolymers of maleic anhydride and
alkyl vinyl ethers were studied primarily by the luminescence quenching method of time-
resolved single-photon-counting. The measured lifetimes of the probe, tris(2,2’-
bipyridine)ruthenium(II), confirm that methyl polyacid undergoes no micelle formation, butyl
polyacid form micelles at low pH and undergoes a conformational transition to random coil
form as pH increases, and hexylpolyacid remains in micelle form over the whole pH range
studied. The solubility of the quencher, 9-methylanthracene, in polyacid solutions, which is
assumed to be proportional to the degree of micellization of polyacid, was determined by
absorbance measurements. A mathematical method for deriving physically significant
parameters from the results of the single-photo-counting measurements was developed. The
results indicated that both static and dynamic quenching take place, suggesting that the quencher
enters the micelle during the lifetime of the excited probe. The micelle size for the hexyl
polyacid was found to be 36, which is independent of the degree of micellization, the
concentrations of polyacid, probe, and quencher, and the molecular weight of polyacid. These
results indicate that a large hydrophobic polyacid molecule in its hypercoiled conformation
consists of many small intramolecular micelle. In quencher-saturated polyacid solutions, only
one third of the micelles contain quencher, while two thirds of the micelles are “empty”. Such a
distribution makes quencher migration between micelles possible. The values of exit rate
constant systematically decrease with the intramolecular micelle concentration, which support
the hypothesis of direct exchange of quencher between intramolecular micelles. Several
possible mechanisms for this migration were discussed. A similar study was performed on
butyl polyacid. The solubility of quencher and the equilibrium constant in butyl polyacid
solution are only half of those for hexyl polyacid, indicating that the longer side chains of the
hexyl polymer provide a more hydrophobic microenvironment to maintain the quencher
molecules in the micelles.
14. Z. Li and Yuanzhen Zhong, “Influence of added salts on the conformation of 6,10-Br ionene
polymer in aqueous solution, ACTA Physico-Chimica Sinica (in Chinese), 1986, 2, pp. 356-362.
15. Z. Li, Yuanzhen Zhong, et al, “Studies of the solution properties of ionenes” (in Chinese),
Zhongshan University Journal, 1983, 2, pp. 33-45.
16. Yuanzhen Zhong, “Solution properties of Ionenes” (in Chinese), M.S. Thesis, 1982,
Zhongshan University, Guangzhou, Guangdong, P.R. China, 72 pages
(END)
Page 17 of 17

(Adam) Y. Zhong - Principal Scientist

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Similar to (Adam) Y. Zhong - Principal Scientist

Similar to (Adam) Y. Zhong - Principal Scientist (20)

(Adam) Y. Zhong - Principal Scientist