El documento describe los componentes típicos y conexiones de un sistema de alarma, incluyendo detectores, central de alarma, batería, sensores, sirena y luces. También menciona nuevos detectores como cámaras y sistemas de alarma inalámbricos vía radio.
Este documento contiene una serie de avisos publicitarios ficticios de una campaña de prensa de la Iglesia de Singapur. Los avisos adoptan un tono humorístico y coloquial para transmitir mensajes sobre temas como el alcoholismo, la religión, el amor de Dios y la dirección en la vida.
El documento describe los componentes típicos y conexiones de un sistema de alarma, incluyendo detectores, central de alarma, batería, sensores, sirena y luces. También menciona nuevos detectores como cámaras y sistemas de alarma inalámbricos vía radio.
Este documento contiene una serie de avisos publicitarios ficticios de una campaña de prensa de la Iglesia de Singapur. Los avisos adoptan un tono humorístico y coloquial para transmitir mensajes sobre temas como el alcoholismo, la religión, el amor de Dios y la dirección en la vida.
O documento descreve um projeto chamado SlowMotion que tem como objetivo aprender em parceria. A equipe do projeto é composta por Denise, Maria, Amélia, Maria José e Valéria.
This document lists various urban sports and activities including street dancing, parkour, skateboarding, biking, rappelling, street soccer, and graffiti. It covers a range of outdoor physical activities typically practiced in urban public spaces.
The document discusses the results of a study on the effects of exercise on memory and thinking abilities in older adults. The study found that regular exercise improved memory and the ability to multitask in sedentary older adults aged 60-79. Participants who exercised 3 times a week for 6 months showed significant improvements in memory, attention, and the ability to juggle multiple tasks compared to a non-exercising control group.
O documento descreve as vantagens da maturidade em três frases. A juventude é lembrada com nostalgia, mas também é cheia de lutas e incertezas. A maturidade traz calma e paz, sem preocupações com tendências ou o futuro. Na maturidade, aproveite a vida sem adiar planos, porque o futuro já chegou.
Topographical guide: "The Ribeiro Wine Route Network" of Walking & Cycling Trails. Topoguía: Rede de Sendeiros e Rutas Cicloturísticas da "Ruta do Viño do Ribeiro". Serviterra Enxeñería
O documento discute estratégias e melhores práticas para ouvidorias em Tribunais de Contas. Ele aborda a importância do planejamento estratégico, da cultura organizacional, da comunicação eficaz e dos relatórios para o bom desempenho da ouvidoria. Também discute competências necessárias para a equipe da ouvidoria e a perspectiva ética do seu trabalho.
This document appears to contain a name, Elena Castellote Aulapf, and some numbers or codes that may be related to an identification number or reference code. The limited information provided does not allow for a more detailed 3 sentence summary.
O documento fornece diretrizes para professores sobre como utilizar efetivamente o laboratório de informática na escola, incluindo planejamento prévio das aulas com atividades apropriadas para a idade dos alunos, testando os sites e atividades antes da aula, e orientando os alunos a ficarem sentados, falarem baixo e cuidarem do laboratório durante a aula.
The document discusses analyzing a cherimoya leaf CO2 extract (CLCO2E) using mid-infrared spectroscopy (MIR) to quantify total acetogenins. It references prior research on health effects of acetogenins from custard apple seeds. The document is a communication between Dr. Abbas and Dr. Arnould on February 20, 2013 regarding obtaining MIR spectra of the CLCO2E.
Este documento presenta una visión general de las acetogeninas de Anonáceas y su potencial contra el cáncer avanzado. Brevemente describe que las acetogeninas son moléculas aisladas de plantas de la familia Annonaceae que son capaces de matar células malignas de manera selectiva actuando sobre el complejo I mitocondrial. Además, propone protocolos para verificar sus efectos citotóxicos e inhibición del complejo I mediante ensayos in vitro y evaluar su toxicidad y eficacia contra tumores en modelos animales mediante ens
O documento descreve um projeto chamado SlowMotion que tem como objetivo aprender em parceria. A equipe do projeto é composta por Denise, Maria, Amélia, Maria José e Valéria.
This document lists various urban sports and activities including street dancing, parkour, skateboarding, biking, rappelling, street soccer, and graffiti. It covers a range of outdoor physical activities typically practiced in urban public spaces.
The document discusses the results of a study on the effects of exercise on memory and thinking abilities in older adults. The study found that regular exercise improved memory and the ability to multitask in sedentary older adults aged 60-79. Participants who exercised 3 times a week for 6 months showed significant improvements in memory, attention, and the ability to juggle multiple tasks compared to a non-exercising control group.
O documento descreve as vantagens da maturidade em três frases. A juventude é lembrada com nostalgia, mas também é cheia de lutas e incertezas. A maturidade traz calma e paz, sem preocupações com tendências ou o futuro. Na maturidade, aproveite a vida sem adiar planos, porque o futuro já chegou.
Topographical guide: "The Ribeiro Wine Route Network" of Walking & Cycling Trails. Topoguía: Rede de Sendeiros e Rutas Cicloturísticas da "Ruta do Viño do Ribeiro". Serviterra Enxeñería
O documento discute estratégias e melhores práticas para ouvidorias em Tribunais de Contas. Ele aborda a importância do planejamento estratégico, da cultura organizacional, da comunicação eficaz e dos relatórios para o bom desempenho da ouvidoria. Também discute competências necessárias para a equipe da ouvidoria e a perspectiva ética do seu trabalho.
This document appears to contain a name, Elena Castellote Aulapf, and some numbers or codes that may be related to an identification number or reference code. The limited information provided does not allow for a more detailed 3 sentence summary.
O documento fornece diretrizes para professores sobre como utilizar efetivamente o laboratório de informática na escola, incluindo planejamento prévio das aulas com atividades apropriadas para a idade dos alunos, testando os sites e atividades antes da aula, e orientando os alunos a ficarem sentados, falarem baixo e cuidarem do laboratório durante a aula.
The document discusses analyzing a cherimoya leaf CO2 extract (CLCO2E) using mid-infrared spectroscopy (MIR) to quantify total acetogenins. It references prior research on health effects of acetogenins from custard apple seeds. The document is a communication between Dr. Abbas and Dr. Arnould on February 20, 2013 regarding obtaining MIR spectra of the CLCO2E.
Este documento presenta una visión general de las acetogeninas de Anonáceas y su potencial contra el cáncer avanzado. Brevemente describe que las acetogeninas son moléculas aisladas de plantas de la familia Annonaceae que son capaces de matar células malignas de manera selectiva actuando sobre el complejo I mitocondrial. Además, propone protocolos para verificar sus efectos citotóxicos e inhibición del complejo I mediante ensayos in vitro y evaluar su toxicidad y eficacia contra tumores en modelos animales mediante ens
This document compares the properties of five natural acetogenins from the Annonaceae plant family as inhibitors of mitochondrial Complex I, the enzyme NADH dehydrogenase, and compares them to the classical inhibitors rotenone and piericidin. Two of the acetogenins, rolliniastatin-1 and rolliniastatin-2, are more potent inhibitors of Complex I than piericidin in terms of inhibitory constant and protein dependence. Rolliniastatin-2 interacts with Complex I in a way that is mutually exclusive with piericidin but not rotenone, making it the first known potent Complex I inhibitor with a binding site distinct from rotenone.
ACG-123-Pawpaw vs. cancer-in vivo-in vitro-MOA McLaughlin-US-2008Ben Rockefeller
information on the annonaceous acetogenins.25,26 The acetogenins
The document summarizes the discovery and development of were shown to be potent inhibitors of mitochondrial complex I and
compounds called annonaceous acetogenins from the paw paw plant. the related cytoplasmic ATP production. Their cytotoxicity, in vivo
The author isolated over 50 unique acetogenins from paw paw and antitumor activity, and a myriad of other potentially useful effects
150 additional ones from related plants. These compounds were indicated applications for pest control, medicine, and more. Some
found to have potent anticancer, pesticidal and other biological
1) The document describes the total synthesis of the natural product 10-hydroxyasimicin, which contains a bis-THF motif in its central core.
2) A key step was the development of a template approach to link two alkenol building blocks and induce stereocontrol during ring-closing metathesis to generate the bis-THF framework.
3) The synthesis involved coupling the building blocks, ring-closing metathesis, asymmetric dihydroxylation, macrocycle opening and elaboration to install side chains, and final coupling and deprotection to yield the target natural product.
This review summarizes knowledge about newly isolated acetogenins from 1998-2004. Over 176 new acetogenins were isolated in this period, bringing the total number isolated to 417. The review describes the extraction, isolation, purification and structural elucidation of these compounds. It categorizes the acetogenins into different groups based on their structures and discusses the biological activities and mechanisms of action of these interesting natural products.
ACG-185-Historic Perspective on Acetogenins-Wu-TW-2010Ben Rockefeller
This document summarizes the history of research on acetogenins from the Annonaceae plant family. It discusses the initial isolation of uvaricin in 1982 which sparked interest in these compounds. Research progressed in three stages from the early 1980s to 2000, focusing on isolation, identification, and determining stereochemistry of various acetogenins. Key accomplishments included classifying compounds by structure and developing NMR methods to determine stereochemistry. Recent studies examined mechanisms of anticancer and other bioactivities. The purpose of this review is to provide an overview of acetogenin research and help clarify their modes of action to guide further development.
ACG-008-Risk-Seeds of annona squamosa-FR-2011Ben Rockefeller
This chapter discusses acetogenins from the seeds of the custard apple (Annona squamosa L.) and their health effects. The custard apple is a tropical tree cultivated for its sweet fruit. Its seeds contain high amounts of annonaceous acetogenins (ACGs), which are potent inhibitors of mitochondrial complex 1. Recent research has found ACGs show antitumor and pesticidal properties. While ACGs have potential health benefits, the seeds also present toxicity concerns that limit their use.
The document summarizes research on herbal medicines in Taiwan, including WYC-01 and WYC-02. It discusses Taiwan integrating traditional Chinese medicine into its national healthcare system, and the World Health Organization's support for traditional medicine development. It then summarizes the characteristics, mechanisms, toxicity tests, and anti-cancer effects of the herbal compounds WYC-01 and WYC-02, which were found to inhibit tumor growth with low toxicity.
This is a lecture by Dr. Jerry McLaughlin about his research into extracts of pawpaw plants, annonaceous acetogenins, in vitro, in vivo, mechanism of action, and toxicity in mice.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
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5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
Study Resources:
1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
