The document outlines the steps in preclinical research, focusing on disease-related genomics, target identification, and lead discovery for potential drug candidates. It discusses various preclinical study models and phases, including in vitro, in vivo, ex vivo, and in silico approaches, along with considerations for toxicity, safety, dosing, and treatment response. It also mentions the investigational new drug application process.

1. 1
STEPS IN PRECLINICAL
RESEARCH
Disease-related
genomics
Target
Identification
Lead
discovery
Potential Drug
Candidate
Preclinical Study
Models and Phases
Investigational New
Drug Application
6
6
in vitro
in vivo
ex vivo
in silico model
2
3 4
5
6
Toxicity, Safety,
Dosing, Treatment
Response Assessment
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