The 5th Annual Sanford Rare Disease Symposium will take place on February 26-27, 2015 in Sioux Falls, SD. The two-day event is organized by Coordination of Rare Diseases at Sanford and Sanford Children's Health Research Center to honor Global Rare Disease Day. The agenda includes presentations on rare neurological disorders, alpha one antitrypsin, Canada's approach to rare diseases, neurofibromatosis type 1, congenital vertebral malformations, unlocking answers for rare disease families and researchers, a porcine model of ataxia-telangiectasia, and undergraduate research on rare diseases. The goal of the symposium is to discover, inspire, and grow knowledge about rare