This study evaluated the efficacy of multispectral data from SPOT 6 and Landsat 8 satellites for detecting and estimating patch sizes of Parthenium weed. Preliminary results found that Parthenium weed infested a total area of 11,748 hectares using SPOT 6 data and 21,845 hectares using Landsat 8 data. Patch sizes ranged from 0.036 to 7.15 hectares using SPOT 6 data and 0.09 to 56.43 hectares using Landsat 8 data. The results indicate detection of Parthenium weed is possible using multispectral data and estimates of patch sizes will enable proper allocation of eradication resources, though optimisation is still needed to obtain accurate patch sizes