This document discusses gastric cancer epidemiology and pathology. It provides statistics on incidence and mortality rates in Europe and the United States. It then discusses various risk factors and classifications for gastric dysplasia and histological subtypes. Finally, it covers tumor staging classifications including TNM and various pathologic prognostic factors.

1. Gastric cancer epidemiology and pathology Gábor Cserni, MD, PhD, DSc Bács-Kiskun County Teaching Hospital Kecskemét, Hungary

4. ACS Facts and Figures 2010 n=12730 n=8270 Estimated deaths: 6350 Estimated deaths: 4220

7. Gastric dysplasia Gut 2000;47:251

9. Histological classification II. ( WHO ) WHO 3rd Edition, 2000

24. Altered scoring system for GC

28. Resection specimen

29. Same resection specimen

30. Same resection specimen

31. HER2 3+ resection specimen

32. Reminder: Same resection specimen could yield biopsies negative or positive for HER2

33. Evaluation summary The above pattern , if well visible at medium (x10, x20) power in at least 5 clustered cells The above pattern , if well visible at medium (x10, x20) power IHC 2+ Strong circumferential, basolateral or lateral staining (visible at low power ) in at least 5 clustered cells Strong circumferential, basolateral or lateral staining (visible at low power ) in at least 10% of the cells IHC 3+ Biopsy Resection HER2 result

35. Gastric tumor in a biopsy

36. Gastric tumor IHC

37. Lobular breast cancer in the stomach i n view of IHC : GCDFP-15 + and ER + a

39. THE END