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The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed. In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine. Bio Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
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This report details the geological observations and interpretations made during a field investigation of the Kaptai Rangamati road-cut section, located in southeastern Bangladesh. The purpose of this report is to document the exposed rock units, their characteristics, and the geological structures present within the road cut.
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Nutrition is the science that deals with the study of nutrients and their role in maintaining human health and well-being. It encompasses the various processes involved in the intake, absorption, and utilization of essential nutrients, such as carbohydrates, proteins, fats, vitamins, minerals, and water, by the human body.
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PESTS OF SUGARCANE - BORERS BORERS 1. Early shoot borer, Chilo infuscatellus, Crambidae, Lepidoptera Symptom of damage: Deadheart in 1-3 month old crop, which can be easily pulled out, rotten portion of the straw coloured dead-heart emits an offensive odour. A number of bore holes at the base of the shoot just above the ground level. Nature of damage: Caterpillar bores into the central shoot and feeds on the internal tissue. This cause interference in the translocation of plant sap and damage the sugar storing tissues. Egg: Flat-scale like eggs are laid in 3-5 rows on the lower surface of leaves in masses of 4-100. The masses are slightly overlapping like tiles. Larva: Larva is dirty white with five dark violet longitudinal stripes and dark brown head. Pupa: Pupation takes place within the tunnel. Caterpillar before pupating makes a large exit hole in the stem and blocks the opening with silken discs. Adult: Pale greyish brown moth with black dots near the costal margin of the forewings and with white hindwings. 2. Internode borer, Chilo sacchariphagus indicus, Crambidae, Lepidoptera Symptom of damage: Internodes constricted and shortened, with a number of boreholes and fresh excreta in the nodal region. Affected tissues reddened. Nature of damage: Caterpillars attack sugarcane plants after 3 months of planting. They bore into the canes near the nodes; entry holes are plugged with excreta. Entry is generally confined to the first five internodes. Egg: Scale-like white eggs are laid by female moths in batches of 9-11, near the midribs, on leaf sheaths or on stem. Larva: White larva with four violet longitudinal stripes and light brown head. Pupa: Pupation takes place in semi-dried leaf sheath. Adult: Pale brown with white hind wings. 3. Top borer, Scirpophaga excerptalis, Pyralidae, Lepidoptera Symptom of damage: Deadheart in grownup canes, which cannot be easily pulled; deadheart reddish brown in colour; parallel row of shot holes in the emerging leaves and red tunnels in the midribs of leaves; bunchy tip due to the growth of side shoots. Nature of damage: Caterpillars are mainly found in the apical portion of the canes, boring through the growing point and down the upper joints until it reaches the sappy portion of the stem, there it feeds on the tissues and destroys the cane. They also bore into the unfolded leaves preferably into the midrib, mining its way to the base. Egg: Eggs are laid on the lower surface of top leaves in clusters particularly near midribs. The clusters are covered with buff coloured hairs. Larva :Smooth, white or cream coloured with a red coloured mid-dorsal line and yellow head. Pupa: Pupation takes place within the larval tunnel in a chamber with an exit hole constructed by the caterpillar. Adult: White coloured moth (with a buff coloured anal tuft in the abdominal tip of female).
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Sérgio Sacani
Biological Diversity Act, 2002 The Biological Diversity Act, 2002 was passed by the parliament of India to protect biodiversity and facilitate the sustainable management of biological resources with the local communities. The Act was enacted to meet the requirements stipulated by the United Nations Convention on Biological Diversity (CBD), to which India is a party.
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National Biodiversity protection initiatives and Convention on Biological Di...
PABOLU TEJASREE
We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors 42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory, as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of 12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy.
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Sérgio Sacani
This pdf is about the Schizophrenia. For more details visit on YouTube; @SELF-EXPLANATORY; https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos Thanks...!
SCHIZOPHRENIA Disorder/ Brain Disorder.pdf
SCHIZOPHRENIA Disorder/ Brain Disorder.pdf
SELF-EXPLANATORY
This is a report about predicting property prices using SVM, random forest and gradient boosting machine
Predicting property prices with machine learning algorithms.pdf
Predicting property prices with machine learning algorithms.pdf
binhminhvu04
Microbial Type Culture Collection (MTCC)
Microbial Type Culture Collection (MTCC)
Microbial Type Culture Collection (MTCC)
abhishekdhamu51
Circulation
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muralinath2
Presentation from the 101st IUVSTA Workshop on High performance SIMS instrumentation and machine learning / artificial intelligence methods for complex data. This presentation describes the issues relating to storing and sharing data from Secondary Ion Mass Spectrometry experiments, and some potential solutions.
FAIRSpectra - Towards a common data file format for SIMS images
FAIRSpectra - Towards a common data file format for SIMS images
Alex Henderson
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Richard's entangled aventures in wonderland
Richard's entangled aventures in wonderland
Richard Gill
Introduction: RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression. It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences. dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants. This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. What are small ncRNAs? micro RNA (miRNA) short interfering RNA (siRNA) Properties of small non-coding RNA: Involved in silencing mRNA transcripts. Called “small” because they are usually only about 21-24 nucleotides long. Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered). Silence an mRNA by base pairing with some sequence on the mRNA. Discovery of siRNA? The first small RNA: In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the development of the worm C. elegans. Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14. Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions. Types of RNAi ( non coding RNA) MiRNA Length (23-25 nt) Trans acting Binds with target MRNA in mismatch Translation inhibition Si RNA Length 21 nt. Cis acting Bind with target Mrna in perfect complementary sequence Piwi-RNA Length ; 25 to 36 nt. Expressed in Germ Cells Regulates trnasposomes activity MECHANISM OF RNAI: First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces. Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands. The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it. THE RISC COMPLEX: RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA Unwinding of double stranded Si RNA by ATP independent Helicase Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA. DICER: endonuclease (RNase Family III) Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC) One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute ARGONAUTE PROTEIN : 1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA 2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity. MiRNA: The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
RNA INTERFERENCE: UNRAVELING GENETIC SILENCING
RNA INTERFERENCE: UNRAVELING GENETIC SILENCING
AADYARAJPANDEY1
Recent discoveries of Earth-sized planets transiting nearby M dwarfs have made it possible to characterize the atmospheres of terrestrial planets via follow-up spectroscopic observations. However, the number of such planets receiving low insolation is still small, limiting our ability to understand the diversity of the atmospheric composition and climates of temperate terrestrial planets. We report the discovery of an Earth-sized planet transiting the nearby (12 pc) inactive M3.0 dwarf Gliese 12 (TOI-6251) with an orbital period (Porb) of 12.76 days. The planet, Gliese 12 b, was initially identified as a candidate with an ambiguous Porb from TESS data. We confirmed the transit signal and Porb using ground-based photometry with MuSCAT2 and MuSCAT3, and validated the planetary nature of the signal using high-resolution images from Gemini/NIRI and Keck/NIRC2 as well as radial velocity (RV) measurements from the InfraRed Doppler instrument on the Subaru 8.2 m telescope and from CARMENES on the CAHA 3.5 m telescope. X-ray observations with XMM-Newton showed the host star is inactive, with an X-ray-to-bolometric luminosity ratio of log 5.7 L L X bol » - . Joint analysis of the light curves and RV measurements revealed that Gliese 12 b has a radius of 0.96 ± 0.05 R⊕,a3σ mass upper limit of 3.9 M⊕, and an equilibrium temperature of 315 ± 6 K assuming zero albedo. The transmission spectroscopy metric (TSM) value of Gliese 12 b is close to the TSM values of the TRAPPIST-1 planets, adding Gliese 12 b to the small list of potentially terrestrial, temperate planets amenable to atmospheric characterization with JWST.
Gliese 12 b: A Temperate Earth-sized Planet at 12 pc Ideal for Atmospheric Tr...
Gliese 12 b: A Temperate Earth-sized Planet at 12 pc Ideal for Atmospheric Tr...
Sérgio Sacani
documents provide information about insect classification and taxonomy of insect
insect taxonomy importance systematics and classification
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