This document discusses approaches for a complex coronary artery bypass graft (CABG) case involving both antegrade and retrograde wiring. It presents several failure scenarios and asks for the next step. For the initial approach, retrograde wiring through the distal cap is preferred, but antegrade or dissection/reentry are alternatives. If retrograde wiring fails, options include using a dedicated microcatheter retrograde or continuing antegrade with a different guidewire or IVUS. If antegrade wiring fails, retrograde or dissection/reentry are considered. For ischemia threatening closure, completing dissection/reentry is suggested. The key learning points emphasize that guidewires can help or hinder, arterial grafts are fragile,