Mayweather vs Pacquiao Stream

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All wait is over. Mayweather will fight Pacquiao in one of the most anticipated fights in boxing history. It has been more than five years in the making and finally happening on 2 May 2015 at MGM Grand Las Vegas, Nevada Watch to live stream : http://t.co/77AogEwbVe

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ABSTRACT: Lung abscess is the necrosis of pulmonary tissue with formation of cavities (more than 2cm)..Predisposing factors include bronchogenic carcinoma or other bronchial obstructions,bronchiectasis and pulmonary infarction. Diagnosis is by chest radiography and computed tomography(CT),Frequently isolated pathogens include anaerobes and nosocomial microorganisms,Staphylococcus aureus, Pseudomonas aeruginosa, mycobacteria,parasites and fungi.Antibiotics of choice include penicillin with β lactamase inhibitors., carbapenem, quinolones, amoxicillin-clavulanate and amoxicillin sulbactam. Metronidazole not so effective because of microaerophilic streptococci. Medical management failure often is secondary to undrained pleural collections, endobronchial obstruction caused by a neoplasm or foreign body. High rates of morbidity and mortality associated with lung abscess despite antibiotic therapy and supported care. Patients with predisposing conditions like a large sized abscess and right-lower lobe location, have the worst prognosis. The prognosis of lung abscess has not improved sufficiently since the introduction of antibiotics, other modalities should be considered for patients with prognostics signs.

Lung Abscess: Diagnosis, Treatment and Mortality

inventionjournals

Comprehensive understanding of gene regulatory networks (GRNs) is a major challenge in systems biology. Most methods for modeling and inferring the dynamics of GRNs, such as those based on state space models, vector autoregressive models and G1DBN algorithm, assume linear dependencies among genes. However, this strong assumption does not make for true representation of time-course relationships across the genes, which are inherently nonlinear. Nonlinear modeling methods such as the S-systems and causal structure identification (CSI) have been proposed, but are known to be statistically inefficient and analytically intractable in high dimensions. To overcome these limitations, we propose an optimized ensemble approach based on support vector regression (SVR) and dynamic Bayesian networks (DBNs). The method called SVR-DBN, uses nonlinear kernels of the SVR to infer the temporal relationships among genes within the DBN framework. The two-stage ensemble is further improved by SVR parameter optimization using Particle Swarm Optimization. Results on eight insilico-generated datasets, and two real world datasets of Drosophila Melanogaster and Escherichia Coli, show that our method outperformed the G1DBN algorithm by a total average accuracy of 12%. We further applied our method to model the time-course relationships of ovarian carcinoma. From our results, four hub genes were discovered. Stratified analysis further showed that the expression levels Prostrate differentiation factor and BTG family member 2 genes, were significantly increased by the cisplatin and oxaliplatin platinum drugs; while expression levels of Polo-like kinase and Cyclin B1 genes, were both decreased by the platinum drugs. These hub genes might be potential biomarkers for ovarian carcinoma.

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ABSTRACT : Renovascular hypertension reflects the causal relation between anatomically evident arterial occlusive disease and elevated blood pressure. The coexistence of renal arterial vascular disease and hypertension roughly defines this type of nonessential hypertension. The aim of this study was to measure the level of serum Anti-Annexin V antibodies in patients with renal hypertension. Methods. This study was conducted on 115 patients, diagnosed with renal hypertension and hypertension. Informed consents were obtained from the patients and the study was approved by the Kharkiv National Medical University ethics committee. Ten healthy age and sex matched volunteers were included as a control group. All patients and controls were subjected to the following full history taking and thorough clinical examination. Routine laboratory testing included a complete blood count, and erythrocyte sedimentation rate (ESR) and kidney function tests (blood urea nitrogen and serum creatinine). Immunological tests for antinuclear antibody (ANA) and anticentromere antibodies (ACA) was performed by the indirect immunofluorescence technique. AntiScl-70 (anti-topoisomerase antibodies) and anticardiolipin antibodies (ACA: IgG and IgM) were tested using the ELISA technique. The anti-annexin V antibodies titre used the ZYMUTEST anti-Annexin IgG ELISA kit. [Hyphen-BioMed, France.]: to measure the IgG isotype of auto-antibodies to annexin V in human serum. Results. Anti-annexin V antibodies were present in 75% of patients (mean 83.46 ± 22.44 AU/mL) vs. 0% in the controls (mean 3.94 ± 4.5 AU/mL). Comparison between patients and controls as regards levels of anti-annexin V showed a highly significant difference (P < 0.001). Furthermore, correlation of anti-annexin V titres with the disease activity score in the patient group showed a statistically significant positive correlation (r = 0.51, P < 0.05).In addition, the anti-annexin V antibody titres in this study showed a highly significant positive correlation with ACL antibodies (r = 0.74, P < 0.001). Patients with antiphospholipid syndrome (APS) have been known to have a higher frequency of anti-annexin V antibodies, and thrombotic events have been reported more frequently in patients with positive anti-annexin V antibodies. Furthermore, inhibition of annexin V binding to negatively charged phospholipids may be an additional pathogenic mechanism of APS.

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ABSTRACT: After having shown that fluoxetine, the active substance of the ISRS antidepressants, has severe adverse effects, we examined the effects of an ACT (anafranil, the active substance being clomipramine hydrochlorid) and an IRSNa (efexor, the active substance being venlafaxine) antidepressants, using identical biological models (= ants) and experimental protocols for comparative purpose. Anafranil appeared to be the less toxic. It reduced the individuals’ activity, precision of reaction, response to pheromones, ‘audacity’, tactile perception, cognitive ability, and aggressiveness towards aliens. It did not impact food consumption, acceptance of congeners, brood caring, visual and olfactory perception. It increased the ants’ ability in acquiring visual and olfactory conditioning, as well as their visual and olfactory memory. Ants developed no habituation and no dependence on anafranil consumption. The effects of that drug linearly vanished in the course of time, in about 28 hrs after its consumption ended. Efexor had more adverse effects. It increased the individuals’ jerking movements, and aggressiveness between congeners. It decreased their precision of reaction, response to pheromones, food consumption, tactile perception, cognitive ability, aggressiveness towards aliens, olfactory perception, ability in acquiring visual and olfactory conditioning, and memory. It did not impact ants’ audacity, brood caring, and visual perception. There was no habituation to and no dependence on efexor consumption. The effects of this drug vanished in 12 h (linear speed), 28 h (sinuosity of movement) and 32 h (precision of response). All the observed effects are either in agreement with those already known, or more precisely described, or newly revealed. In fact, the ACT antidepressants are the less toxic, the IRSNa are somewhat dangerous, while the ISRS have severe adverse effects. Attention should also be paid to the presence of such drugs, largely consumed and eliminated intact, in natural water, impacting then the physiology and the behavior of all the living organisms.

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