1. 12/3/2013
Smart Big Data’s New Role in
Optimizing Clinical Trial Efficiency
UP 2013
Santa Clara
Proprietary
Robert A. Downing II.
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2. Why Utilize Big Data Now?
12/3/2013
1. Unstructured big data is ~80% of all useful information
2. Unstructured big data is growing at >10x rate of structured data
Web 1.0
Google
Yahoo
MS
>$100B Market
Wave 3.0 …..
The Need to Extract Trends &
Meaning from Big Data Chaos
in ‘Real Time’
Web 2.0
Facebook
LinkedIn
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Unstructured data growth
[Source: Merrill Lynch]
Twitter
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2000s
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2010s
© Trendicy Corp
2020s

3. The Provider-Centric View
12/03/13
Physician
Nursing
staff
Proprietary
Office staff
PORs
Patients
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4. The Patient-Centric View
12/03/13
Patients
PORs
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Office staff
Nursing staff
Physicians
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UP 2013, Santa Clara

5. The SaaS View
12/03/13
Cloud
Patients
Nursing
staff
PORs
Office staff
Office staff
PORs
Nursing staff
Patients
Physicians
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Physician
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6. SaaS Model Benefits
12/03/13
• Accessible
• From any browser, anywhere
• Reliable
• Always up, with built-in fault tolerance
• Robust
• Scalable with demand
• Multi-protocol support (including secure protocols),
with address obfuscation
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• Secure
• Low Cost-of-Ownership
• Installation, maintenance, support someone else’s problem
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7. Big Data Obstacles
• SaaS relatively new, & some vendors even newer
12/03/13
• Lack of history
• Lack of selection criteria
• Too many claims by too many participants
• Too few recognized leaders
• Security
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• Distrust/Mistrust still exists, largely because of perceived
shortcomings in standards for verification & vague external
accountability
• Legislation
• PPACA
• HIPAA
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8. New Solutions
12/03/13
• History
• Get references from any vendor, & ask for their competitors
• Selection criteria
• Nothing is too insignificant to ask, then demand if necessary
• Security
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• Demand the best, & ask for logical or physical isolation if
needed
• Vendor(s) should be able to provide HIPAA compliance
• Follow your gut
• But be realistic
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9. Making the Case [Study]
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• Plan the protocol
• Source(s) of data
• Type(s) of data
• Reliability / Veracity
• Gather & ‘map’ the data
• Evaluate additional sources, types of data
• Look for better / more reliable sources
• Plan the cost?
12/03/13
• Plan the Goals, & Path(s) to Get There
• Dynamism Can Affect / Improve Confidence
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UP 2013, Santa Clara

10. Traditional Protocol
12/03/13
• Medical Hx
• Questionnaire
• Visits
• Additional questionnaires
• Investigators’ notes
• Verbalization transcription
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UP 2013, Santa Clara

11. Expanded Protocol
•
•
•
•
•
Other providers records
Hospitalization records
Licensed practitioner records
Support communities
Other…
• Graphical
• Contextual
• Meaningful
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• Information at A Glance
12/03/13
• Sponsor / PI EHR / EMR plus
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12. Contextual Look
12/03/13
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13. Contextual Analysis
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14. Intuitive User Interface
12/03/13
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15. Actionable Analytics
12/03/13
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16. Big Data’s New Role
… Driving Clinical Trial Efficiency
12/03/13
• Graphical
• Easy to understand graphics display insight at a glance
• Points in time are data, not answers
• Answers come from measuring change / time
• Contextual
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• Questions should be defining the shape of the answers
• Environment should be defining the measures
• Meaningful
• Answers should lead directly to action, without any
intervening step or steps
• Analytics need to be actionable
UP 2013, Santa Clara
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17. Thank you….
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robert.downing@trendicy.com
T: 510.516.1812
M: 510.468.0066
SkypeID: radowningii
Twitter: TrendicyRob
12/03/13
Robert Downing II
Founder & CEO
www.trendicy.com
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UP 2013, Santa Clara