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Specific
pathogenic
bacteria
Host
immune
inflammato
ry
response
Connective
tissue &
bone
metabolism
Clinical
expression
of disease,
initiation
progression
Environmental &acquired risk factors [SMOKING]
Genetic risk factors
LPS
MMPS
CYTOKINES
PMNS
REWARD CIRCUIT OF BRAIN
It includes ventral tegmental
area which connects to nucleus
accumbens, the pre fontal cortex
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium
Smoking & periodontium

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