10. Cytokine families
I. Hematopoietic family
II. Interferon family
III. Tumor necrosis factor family
IV. Chemokine family
I, II, and III elicit physiological responses.
IV serves as a chemoattractant.
13. Tumor necrosis factor…
• Time to be critical…
• Question: What does the text say?
• Answer: Not a lot.
– More specifically, there is no text.
– There is an entry in Table 12.1 (which
stretches over four pages!) What does it
say?
– “Has toxic effects. Induces cytokine
secretion…”
14. So, something’s amiss…
• Try another approach.
• Cytokines are soluble immunomodulators.
• That means that they are ligands.
• Question: Can they be characterized in
terms of their receptors?
• Answer: Yes.
16. Of receptors and signal transduction…
• Receptors for cytokines have surface
component, single transmembrane
component, and cytoplasmic tails.
• Commonly multimeric. The protomers
can associate in different groupings; the
various associations have different
affinities for cytokines; hence, different
intensities of signaling.
• The different protomers also have
different signaling functions, e. g.
phosphorylation sites.
17. What are the principal signaling systems?
JAK’s
&
STAT’s
21. Some terms (from Horst Ibelgaufts):
cytokine network (aka: Neuroimmune network ).
“This is, of course, true to the extreme: connect
everything with everything in a diagram of
100 cell types and 500 factors -and add some
extra lines.”
Synonyms:Horst Ibelgaufts'COPE: Cytokines Online Pathfinder Encyclopaedia
zoo of factors
jungle of interactions
deep morasses of acronyms
bleak deserts of synonyms