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2. Outline of Talk
Global perspective
Need of Hour: MSC as a drug molecule
Drugs ≠ Regeneration thus Stem Cells
What is Regenerative Medicine
Stem Cells are the main stream
MSC- as drug

3. India

4. Innovations are required…
new treatment therapies are required………..
“We can’t solve the problem by using the same kind of
thinking we used when we created them”
- Albert Einstein

5. A Paradigm Shift in Healthcare
Heading towards cure from signs and symptoms
suppression
Assure complete safety and minimum side effects
Also ensure long-term benefits
Need of the hour….

7. “Cells are not single molecular agents but are
rather, site-regulated, adaptive agents
capable of very complex functions involving
a multitude of bioactive factors and
reactivities.”
MSC: A complete genome for healing is
available
Drug: A single molecule with limited
applications

8. Repair

9. Stem Cell Potential..
Repair
Rejuvenate
Replace
Restore
Maintain
Enhance
…. This is regardless of any cause for the injury to the
cell or tissue or organ….

10. Stem Cells Applications : Hype or Hope
“ Imagine if a doctor says to you that you are diagnosed with an
untreatable condition and you have to live with it and die with it
….what will be your state !!!!!”
A story from fiction to facts

12. “I have thought a lot about stem cells , and I am sure that
when the historians will look back at the 20th
century…the
greatest scientific achievement will not be from the field of
space technology or computer technology but will be from the
tissue engineering and genetic medicine.”
-Michael Goulian
-ABC Scientific News Reporter,
29-9-1999.

13. Are we churning the old wheel
again??

14. YOU ARE ALIVE….
Blood Every Second
Skin Every 2 Weeks
Bones Every 20 Years
Your Innate Regenerative Capacity

18. Regenerative
Medicine
Tissue Engineering

19. MSCs and Pericytes
Chang’s hypothesis
Pericytes are present on the capillaries and micro-
vessels
These pericytes appear to be getting recruited by
body’s intelligence upon any injury…
Pericytes also appear to understand the injury process
as well as the required repair mechanism…
They are the mechanics, getting all the spare parts in
place..or may be working just as bio-catalysts

20. All MSCs are pricytes…but all pericytes are not MSCs….

23. MSC as antibacterial activity, antibacterial protein
Human CAP-18/LL37

24. This calls for a new thought…
Are MSCs merely MSCs or…
they actually are..
“Medicinal Signaling Cells” …?
A complete regenerative micro-environment
created…
Act like an injury-specific drug store!!

31. Trophic Factors

37. Over-all drug-like actions of MSCs
Immuno-modulatory: control immune function in
facvour of body
Anti-inflammatory: reduce unwanted compensatory
mechanisms
Anti-apoptotic: Allow regeneration
Cell differentiation: all functions regained
Protein and cytokine synthesis (through mRNA
activation): Micro-environment enrichment
Angiogenic: assurance of continued effect
Anti-Bacterial activity & Release micro verticals
transporting functional mRNA & micro RNA

38. One MSC….ALL ACTIONS!!

39. What is MSC exactly???
Mesenchymal Stem Cell??
Mesenchymal Stromal Cell??
Medicinal Signaling Cell??

40. ISCT definition
A cell that adheres to plastic
Expresses CD 105, 90, 73
Does not express CD 34, 45 and 13
HLA DR is absent
All these virtues of this MSC make them interesting,
innovative drug molecule…

41. Additional features…
MSCs can be customized as per need…
The immunomodulating action can be modified as
per need…
TLR 4 priming…. Pro-inflammatory---MSC1
TLR3 priming….immuno-suppressive…MSC2

42. How about tumorogenicity??
Autologous MSCs Allogenic MSCs
DNA garbage accumulation
Mutations
Senescence
Telomer e shortening
Malignancy not possible
Xeno in nature..
Hence, preferential
elimination by the recipient
body
No scope for any malignancy
This very fact makes Allogenic-MSCs as best choice future drugs!!

47. “ You carry your own repairing kits
in your body”