Transfer factors are small peptides found in colostrum that educate and alert the immune system. Unlike antibodies, transfer factors are not consumed when performing their role of transmitting immune information between cells. They were discovered in 1949 by Dr. H. Sherwood Lawrence and have since been the subject of over 3,000 research studies. 4Life's Transfer Factor is produced from cow colostrum using a patented process that subjects the product to pasteurization and other safety standards while maintaining the potency of the transfer factors.

1. FAQ – Transfer Factor
ANTIBODIES:
o What is the difference between transfer factors and
antibodies?
Unlike antibodies that are large proteins, transfer factors are small peptides containing
about eight amino acids.The small size of the transfer factors makes them non-allergenic.
Antibodies are consumed by directly attaching themselves to the offending cell or protein.
Transfer factors perform a different role. Transfer factors are immune messenger
molecules that educate and alert naive immune cells to an impending danger. In this regard
transfer factors perform a catalytic role in the immune system, triggering the affect without
themselves being consumed. ~ Transfer factor preparations consist of three identifiable
fractions.
APPROVAL:
o Is transfer factor FDA approved?
Foods and dietary supplements are not approved per se by the FDA. Food supplements
derived from milk would certainly fall under the category of Generally Recognized As Safe
(GRAS)
o Is Transfer Factor approved by the USDA?
Transfer Factor XF™ is produced within the bounds of a USDA certified plant which follows
established protocol for dairy production, including pasteurization and safety guidelines.
Furthermore, Transfer Factor™, as a human-grade product, exceeds standards established
for animal-grade products. Each batch of Transfer Factor XF™ undergoes strict microbial
and potency tests to assure quality time after time.
CLINICAL TRIALS:
o Are there research studies available on transfer factors?
4Life has made available three booklets containing condense information from the volumes
of research available on transfer factors and the components that were brought together in
Transfer Factor Plus™. The first booklet is Transfer Factor by William Hennen, Ph.D. the
second is called Enhanced Transfer Factor, also by Dr. Hennen. A third booklet by Rita
Elkins, MH, is also entitled Transfer Factor, and is written in layman’s terms so the general

2. population can gain additional knowledge. Each of these booklets contains hundreds of
references.
CONTINUAL USE:
o Why do we need to use Transfer Factor™ if we received
immune information when we were infants?
The transfer factors we received as infants are just purposeful as those available in
Transfer Factor™. As infants, mother’s colostrum gave immune information while our
immune systems were not fully developed, but the transfer factors were absorbed into the
bloodstream and eventually were used up to become part of the functioning immune
system, consisting of lymphocytes, natural killer cells, macrophages, etc. The information
provided at birth was to work against the specific threats experienced by your mother at
that time; after years of life new threats to the immune system exist. By using oral transfer
factor we are providing the same type of immune information we received at birth.
DISCOVERY:
o Who discovered transfer factors and when?
In 1949, Dr. H. Sherwood Lawrence made a revolutionary discovery while studying
tuberculosis. He determined that an immune response could be transferred from a donor to
a recipient by injecting an extract of white blood cells (leukocytes) from a previously
infected, now healthy, subject into a newly infected patient. He found that this extract
contained a factor capable of transferring immunity³. He named the substance “transfer
factor.” Dr. Lawrence’s discovery came in the midst of the discovery and use of antibiotics.
Transfer factors have been used throughout the antibiotic age in different regions of the
world such as China, Poland, Italy and others, but never have been available commercially
due to the lack of technology. In the fifty years since Lawrence’s pioneering work, an
estimated $40,000,000 has been spent on research resulting in over 3,000 published
scientific papers documenting the benefits of transfer factors. The world’s leading scientists
and physicians have established the safety and remarkable immune system benefits of
transfer factors. The processing methods that allow for largescale extraction of transfer
factors have only recently been perfected and a commercial product has only been
available within the last few years.
o How does ingesting transfer factors orally compare to
injecting transfer factors from blood preparations?
Generally, the effects are very similar no matter how transfer factors enter the body.
Because transfer factors originate in the blood, the source of transfer factors is identical

3. whether they reenter the body in concentrated form such as 4Life™ Transfer Factor™, or
by injection.
HEAT:
o Is there heat used in processing Transfer Factor™?
Yes, the normal pasteurization process is applied to the colostrum followed by low
temperature heat dehydration. The peptide structure of transfer factor is not broken down
or effected at the heat level that is used in the pasteurization process. Vitamins, herbs, and
peptide structures each have a different threshold at which heat is harmful to its bioactivity.
o Is there a limit to how hot the product can get?
Yes. Colostrum undergoes a brief heat process that is limited to proper pasteurization
methods. This amount of heat does not affect transfer factor activity.
o Is the transfer factor molecule heat sensitive? What about
increased temperatures in shipping of the product to the
customer?
A proprietary protein stabilization method is used to maintain transfer factor activity during
the processing of Transfer Factor.
HOW:
o How do transfer factors work?
Transfer factors are tiny molecules found in colostrum, which provide “immune knowledge”
from a mother’s immune system to her baby used in recognizing and fighting outside
threats. By transferring information from cell to cell, transfer factors serve as “teachers” to
the new cells, ensuring a strong immune system capable of surviving, even thriving, in its
new environment. Transfer factors are not species-specific and can therefore be extracted
from any mammal and then be given to another mammal with the same efficacy.
MANUFACTURING:
o Who manufactures your products?
4Life manufactures it’s own products in order to maintain control over quality and
availability.
SAFETY²:

4. o Can Transfer Factor be taken during pregnancy
There have been no adverse responses reported while taking Transfer Factor during
pregnancy. As with all supplements, consult a physician before use.
o Can it be taken with any other vitamins, ginseng or any other
nutritional product?
TF and TF+ are compatible with any other type of nutrient.
o I have heard reports of people exceeding the recommended
serving size of Transfer Factor. Is this safe?
The recommended maintenance amount is 3 capsules a day.
o Is it safe to take multiple capsules of Transfer Factor™ a
day?
There is no known toxicity level associated with Transfer Factor™.
o Can a person use more than the recommended serving size
of Transfer Factor Plus™?
The best and safest way to begin using Transfer Factor Plus™ is to use the recommended
serving size as listed on the product label.
STOMACH ACIDS:
o Do stomach acids or other functions of the digestive tract
neutralize transfer factors?
Stomach acid or digestive enzymes do not degrade the potency of transfer factor.
VALIDATION:
o Have transfer factors been scientifically validated?
Since Lawrence’s discovery of transfer factor in 1949³, there have been over 3,000
scientific studies published on transfer factor.
WHAT:
o What are transfer factors?
Transfer factors are memory molecules in your immune system that store all of the
experiences of your immune system. They police your body looking for invading germs. A

5. transfer factor is a peptide of 40 amino acids, which change their arrangement to form
different communications. These amino acids act like the alphabet. You can arrange the
twenty-six letters of the alphabet into thousands of words that communicate meaning.
These amino acids can form into thousands of arrangements. Each of these arrangements
describe a particular bacteria, virus, parasite, or fungi. Other immune cells can read this
biochemical communication. Cells within your body communicate between themselves to
form combat strategies in order to keep you well. Don’t confuse amino acids with protein. It
requires more than 100 amino acids to constitute a protein. Amino acids are the building
blocks to many different chemicals and substances in the body besides proteins. Transfer
factors are the “brains” of the immune system. Through a special patented process
licensed to 4Life Research™, concentrated transfer factors can nowbe extracted from cow
colostrum.
o Are transfer factors made of sugars, proteins or fats?
Isolated transfer factors have been determined to be a chain of small peptides consisting of
44 amino acids. Amino acids are the building blocks of proteins.
o Is it a vitamin, mineral or herb?
No. It is a supplement unlike any other. It is in a class of it’s own
o What role do transfer factors play in the immune system?
These are an inducer fraction, an antigen specific fraction and a suppressor fraction.¹ The
immune system must be able to respond quickly, respond specifically and not exhaust itself
by over responding and attacking normal tissue. The three transfer factor fractions were
named because of the discovered affects they had on immune system. The inducer fraction
triggers a general state of readiness in the immune system. The antigen specific fraction is
an array of critical tags used by the immune system to identify a host of enemy microbes.
The suppressor fraction is as important as the other fractions in that the components of this
fraction keep the immune system from focusing all its strength on a defeated infection while
ignoring new microbial threats. The suppressor fraction is also responsible for controlling
allergic reactions and blocking autoimmune disorders.
WHERE:
o Where are transfer factors found?
In the blood, in the first milk after a mother gives birth, and chicken eggs.
References:

6. 1. Biotherapy 1996;9(1-3):1-5
Transfer factor–current status and future prospects.
Lawrence HS, Borkowsky W.
Department of Medicine, New York University Medical Center, New York, NY 10016, USA.
2. Biotherapy 1996;9(1-3):175-85
In vitro studies during long-term oral administration of specific transfer factor.
Pizza G, De Vinci C, Fornarola V, Palareti A, Baricordi O, Viza D.
Immunodiagnosis and Immunotherapy Unit, S. Orsola Malpighi Hospital, Bologna, Italy.
3. Proc Soc Exp Biol Med 1949;71,716
The Cellular transfer of cutaneous hypersensitivity to tuberculin in man.
Lawerence HS
4.Ann N Y Acad Sci. 1993 Jun 23;685:362-8.
Structural nature and functions of transfer factors.
Kirkpatrick CH.
5. J Interferon Cytokine Res. 2000 Apr;20(4):439-41.
Eleventh International Congress on Transfer Factors: March 1-4, 1999, Monterrey,
Nuevo
Leon, Mexico.
Dumonde DC, Kirkpatrick CH, Pizza G.
6. Eur J Cancer. 1977 Sep;13(9):917-23.
Effect of in vitro produced transfer factor on the immune response of cancer
patients.
Pizza G, Viza D, Boucheix C, Corrado F.
7. Proc Soc Exp Biol Med. 1985 Mar;178(3):468-75.
Transfer factor for the treatment of HBsAg-positive chronic active hepatitis.
Roda E, Viza D, Pizza G, Mastroroberto L, Phillips J, De Vinci C, Barbara L.