Certain drugs and medications can have harmful effects on the kidneys. Some examples include:
Nonsteroidal anti-inflammatory drugs (NSAIDs): These drugs are commonly used to relieve pain and reduce inflammation. However, they can cause kidney damage, especially if taken for a long period of time or in high doses.
Antibiotics: Some antibiotics, such as gentamicin and vancomycin, can cause kidney damage.
Contrast dyes: These are used in certain medical procedures, such as CT scans and angiograms. They can cause kidney damage, especially in people with pre-existing kidney problems.
Chemotherapy drugs: Some chemotherapy drugs can cause kidney damage.
Immunotherapy drugs: Some immunotherapy drugs used to treat cancer and autoimmune diseases can cause kidney damage.
It's important to talk to your doctor about any medications or drugs you are taking and to monitor your kidney function regularly, especially if you have pre-existing kidney problems.
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2. DRUG INDUCED
NEPHROTOXICITY
Drugs are a common source of
acute kidney injury.
They cause approximately 20
percent of community and hospital
acquired episodes of acute renal
failure
3. MECHANISMS OF DRUGS
INDUCED INJURIES
These include altered intraglomerular
hemodynamics, tubular cell toxicity,
inflammation, crystal nephropathy,
rhabdomyolysis, and thrombotic
microangiopathy
6. ACYCLOVIR (ZOVIRAX)
Crystal nephropathy The intrinsic
nature of some molecules and ions
combined with a favorable tubular
fluid physiology leads to crystal
precipitation and deposition within
the tubular lumens.
7. AMINOGLYCOSIDES
Tubular cell toxicity is damage to the
tubule cells of the kidneys, which
can lead to acute kidney failure. The
tubules are tiny ducts in the kidneys
that help filter the blood when it
passes through the kidneys.
8. CLOPIDOGREL
(PLAVIX)
It cause Thrombotic
microangiopathies (TMA) that are
defined by the presence of
hemolytic anemia (destruction of
red blood cells), low platelets, and
organ damage due to the formation
of microscopic blood clots in
capillaries and small arteries.
