Opening Week NFL odds for 2016 are posted by the NFL Specialists at top sports handicapping and NFL and college football picks site OffshoreInsiders.com. The MasterLockLine traces its roots back to 1980.

1. Week 1 NFL Odds 2016
OffshoreInsiders.com

2. OffshoreInsiders.com
WEEK 1
8:30 PM
451 Panthers -2 (-110) 43½ (-110) -
452 Broncos +2 (-110) 43½ (-110) -
Sunday, 11th September 2016
WEEK 1
1:00 PM
453 Buccaneers+3 (-105) 47½ (-110) -
454 Falcons -3 (-115) 47½ (-110) -
1:00 PM
455 Vikings -3 (-110) 42½ (-110) -
456 Titans +3 (-110) 42½ (-110) -
1:00 PM
457 Browns +7 (-115) 45 (-110) -
458 Eagles -7 (-105) 45 (-110) -

3. OffshoreInsiders.com
1:00 PM
459 Bengals -1 (-110) 42½ (-110) -
460 Jets +1 (-110) 42½ (-110) -
1:00 PM
461 Raiders +1½ (-115) 50½ (-110) -
462 Saints -1½ (-105) 50½ (-110) -
1:00 PM
463 Chargers +7 (-110) 43 (-110) -
464 Chiefs -7 (-110) 43 (-110) -
1:00 PM
465 Bills +2½ (-110) 43 (-110) -
466 Ravens -2½ (-110) 43 (-110) -
1:00 PM
467 Bears +6 (-115) 44 (-110) -
468 Texans -6 (-105) 44 (-110) -

4. OffshoreInsiders.com
1:00 PM
469 Packers -4 (-115) 47 (-110) -
470 Jaguars +4 (-105) 47 (-110) -
4:05 PM
471 Dolphins +8 (-110) 44 (-110) -
472 Seahawks -8 (-110) 44 (-110) -
4:25 PM
473 Giants +3½ (-110) 49 (-110) -
474 Cowboys -3½ (-110) 49 (-110) -
4:25 PM
475 Lions +5 (-105) 49 (-110) -
476 Colts -5 (-115) 49 (-110) -
8:30 PM
477 Patriots PK (-105) 51 (-110) -
478 Cardinals PK (-115) 51 (-110) -

5. OffshoreInsiders.com
Monday, 12th September 2016
WEEK 1
7:10 PM
479 Steelers -3 (-110) 50½ (-110) -
480 Redskins +3 (-110) 50½ (-110) -
10:20 PM
481 Rams-2 (-110) 46 (-110) -
482 49ers+2 (-110) 46 (-110) -