Effect of vit D supplement in bone mass in infant

1. WELCOMETO JOURNAL
CLUB
Presented by
Dr. Faria Hossain.(MD.PhaseA)
DrTasnima Nowrin.(MD.PhaseA)
Dr Nusrat Ajmir Akther.(MD.PhaseA)

2. Effect of vitamin D supplementation on bone mass
in infants with 25-hydroxyvitamin D concentrations
less than 50 nmol/L
• Source : JAMA pediatr.2023;177(4):353-362
• https://jamanetwork.com

3. Authors
• Nathalie Gharibeh,PhD
• Maryam Razaghi ,PhD
• Catherine A.Vanstone ,RN,MSc
• Olusola F. Sotunde, PhD
• Laura Glenn,RD,MSc
• Kristina Mullaho,RD,MSc
• Zahra Farahnak,PhD

4. Authors cont..
• Ali Khamessan,PhD
• Shu Qin Wei,MD,PhD
• Dayre Mcnally,MD,PHD
• Frank Rauch,MD
• Glenville Jones,PhD
• Martin Kaufmann,PhD
• Hope A.Weiler,PhD

5. INTRODUCTION
• Vitamin D status at birth reflects maternal-fetal transfer of 25-
hydroxyvitamin D.
• The recommended dietary allowance for vitamin D for pregnancy and
lactation is set at 600 IU per day .
• Human milk does not provide vitamin D in amounts consistent with the
adequate intake for infants (400 IU per day).Therefore public health policies
in north America recommend that all breastfed infants begin vitamin D
supplementation (400 IU per day ) shortly after birth.

6. INTRODUCTION cont..
• The recommended amount of vitamin D for infants is set in accordance with
intakes that maintain serum 25(OH)D concentration.
• Studies shows that 400 IU per day of vitamin D supplementation during the
first year of life prevents vitamin D deficiency Rickets.
• The objective of this study was to compare the effect of 1000 IU per day of
oral vitamin D supplementation vs 400 IU per day on bone mass from age 1
to 12 months in infants born with serum 25(OH)D concentrations less than
50 nmol/L.

7. METHODOLOGY
• Sample size : 139 children ,boys 81 & girls 58.
• Age : 1 to 12 months of age
• Study place : Montreal,Quebec,Canada
• Study period : March 2016 to March 2019
• Study type : Double blinded randomized clinical trial

9. INCLUSION CRITERIA
• Healthy term singleton infant
• 1-12 months of age
• Appropriate weight for gestational age
• Mothers had intend to breastfeed to atleast 3 months of age

10. EXCLUSION CRITERIA
• Maternal comorbidities
• SGA,LGA,Preterm,Multiple births
• Infant comorbidities
• Had no intend to breast feed
• Were smokers