Which of the following is true about replication? The lagging strand is synthesized in a continuous fashion and the leading strand is not Helicase unwinds RNA Primases lay down the primers on the lagging strand Topoisomerase unwinds DNA Solution The only correct statement among the four in the given question is \'Topoisomerase unwinds DNA\'. Explanation for others are; leading strand is synthesized in continuous fashion whereas lagging strand is not, helicase unwinds DNA (which is double stranded) not the RNA (which is single stranded), primases lay down the primers on both, the leading as well as the lagging strands..