Critical thinking question: what structural features (hint: there are four) do all ten of these opioid drugs have in common? Opioids Opioids are a powerful class of alkaloids that act on the central nervous narcotic analgesics. All opioids presumably bind to the same mu-opioid receptor sites in the brain and spinal cord. The most prevalent naturally occurring isolated from the opium poppy-is morphine (named after Morpheus, the sod of dreams). A methoxy derivative of morphine that is also isolated from opium poppy is codeine, which is both less addictive and less effective as a reliever than morphine. By contrast, the diacetyl derivative of morphine (heroin) isanalgesic not only a more powerful as a narcotic but also more addictive than morphine Many other synthetic derivatives of morphine are opioid agonists that are used as narcotic analgesics (including oxycodone, oxymorphone, hyd system as a plant-derived nitrogenout bases that have pronounced physiologial acevity on humans the arcotic a drug dhas numbs the ngonisa molecule that combines antagonist a molecule that inhibits senses and induces stupor a druE hat with a receptor to initiate and meperidine), while others (such as methadone and buprenorphine) are used to treat opioid addiction. Naloxone is an opioid antagonist that is used to counteract opioid overdose the physiological action of anocher CHyo 0 CH, Ho* CH CH (OxyContin) (Opana) Dlaudid) (Demerol Ph N-CH3 CHa (where Ph (Butrans, Suboxone) ritical Thinking Question Phat structural features (hint: there are four) do all ten of these opioid drugs have in commom? mene ving, Contein nivonen Solution Common features in all the given opiod structures are - 1. Presnece of a tertiary amine group. 2. Presence of a phenyl ring. 3. At least two rings are there in all the molecules. 4.All the opioids are polar compounds. .

1. Critical thinking question: what structural features (hint: there are four) do all ten of these opioid
drugs have in common?
Opioids Opioids are a powerful class of alkaloids that act on the central nervous narcotic
analgesics. All opioids presumably bind to the same mu-opioid receptor sites in the brain and
spinal cord. The most prevalent naturally occurring isolated from the opium poppy-is morphine
(named after Morpheus, the sod of dreams). A methoxy derivative of morphine that is also
isolated from opium poppy is codeine, which is both less addictive and less effective as a reliever
than morphine. By contrast, the diacetyl derivative of morphine (heroin) isanalgesic not only a
more powerful as a narcotic but also more addictive than morphine Many other synthetic
derivatives of morphine are opioid agonists that are used as narcotic analgesics (including
oxycodone, oxymorphone, hyd system as a plant-derived nitrogenout bases that have pronounced
physiologial acevity on humans the arcotic a drug dhas numbs the ngonisa molecule that
combines antagonist a molecule that inhibits senses and induces stupor a druE hat with a receptor
to initiate and meperidine), while others (such as methadone and buprenorphine) are used to treat
opioid addiction. Naloxone is an opioid antagonist that is used to counteract opioid overdose the
physiological action of anocher CHyo 0 CH, Ho* CH CH (OxyContin) (Opana) Dlaudid)
(Demerol Ph N-CH3 CHa (where Ph (Butrans, Suboxone) ritical Thinking Question Phat
structural features (hint: there are four) do all ten of these opioid drugs have in commom? mene
ving, Contein nivonen
Solution
Common features in all the given opiod structures are -
1. Presnece of a tertiary amine group.
2. Presence of a phenyl ring.
3. At least two rings are there in all the molecules.
4.All the opioids are polar compounds.