This document discusses inflammation, describing it as the body's response to infection or tissue damage that brings cells and molecules to fight offending agents. The inflammatory reaction involves recognizing the agent, recruiting leukocytes and proteins from blood to the site, activating these to destroy the agent, controlling the reaction, and repairing tissue damage. It notes the major participants are blood vessels and leukocytes, and that inflammation can be either local or systemic. While usually beneficial, inflammation can also have harmful consequences if not properly regulated and resolved.

2. INFLAMMATION
Dr. Md. Shajjad Hossain
Lecturer
Department of Pathology
Dhaka dental college

3. Inflammation
• Inflame” – to set fire
• Inflammation is a response of vascularized tissues to
infections and damaged tissues that brings cells and
molecules of host defense from the circulation to the sites
where they are needed, in order to eliminate the offending
agents.

4. Steps of inflammatory reaction
• The offending agent, which is located in extravascular
tissues, is recognized by host cells and molecules.
• Leukocytes and plasma proteins are recruited from
the circulation to the site where the offending agent
is located.
• The leukocytes and proteins are activated and work
together to destroy and eliminate the offending
substance.(Removal)
• The reaction is controlled and terminated(Regulation)
• The damaged tissue is repaired(Resolution)

5. Fundamental properties
• Components of the inflammatory response. The major participants
in the inflammatory reaction in tissues are blood vessels and
leukocytes.
• Harmful consequences of inflammation.
• Local and systemic inflammation: The reaction is largely confined to
the site of infection or damage and sepsis, which is one form of the
systemic inflammatory response syndrome.
• Mediators of inflammation: Soluble factors from cells or plasma
proteins.

6. Continue…..
• Acute and chronic inflammation.
• Termination of inflammation and initiation of tissue repair.

7. Advantages
• Inflammation usually functions in a beneficial manner and serves to destroy,
dilute or wall off the injurious agent, remove necrotic debris and other exudates.
• Without inflammation---
 Infections would go uncheked
Wounds never heal
 Tissue remain permenant festering sores
• Inflammation is intimately associated with the repair process which includes
parenchymal cell regeneration and scarring.