A presentation about a new method for delivary of a drug to a target site within the body and to enhance its kinetics including absorption and bioavailability as a promising method using certain compounds

1. Self- Emulsifing Drug
Delivary
Systems(SEDDS)

2. Oral route is the
most perferred route
but…

3. How????

4. Contents:
1.Definition.
2.Composition of SEDDS.
3.Mechanism of SEDDS.
4.formulation approach.
5.Evaluation Tests.
6.conclusion.

5. Self-emulsifying drug delivery
systems (SEDDS)
Definition:
Are isotropic mixtures of natural or
synthetic oils, solid or liquid surfactants
or alternatively, one or more hydrophilic
solvents & co-solvents/co-surfactant

6. Advantages
1. Enhanced oral bioavailability.
2. Selective targeting of drug(s) toward specific absorption in GIT.
3. Protection of drug(s) from the hostile environment in gut
4. Reduced variability including food effects.
5. Protective of sensitive drug substances.

7. Drawback Of SEDDS
1. Lack of good predicative in vitro models for assessment
of the formulations.
2. A large quantity of surfactant may irritate the GIT.
3. Volatile co-solvents can migrate on capsule shell .

8. Drug surfactant
CO-Serfactant oil
SEDDS

9. Properties of SEDDS
1
• They are able to self emulsify rapidly in gastro-intestinal fluids &
under the influence of gentle agitationprovided by Peristaltic and
other movements of gastro intestinal tract, they form a fine o/w
emulsion.
2
• They can effectively incorporate drug (hydrophobic
or hydrophilic) within the oil surfactant mixture.
3
• They can be used for liquid as well as solid dosage
forms.

10. TYPES OF S-SEDDS
capsules
Tablets
pellets
powders
Implants
Solid
dispersions

11. Mechanism of self
emulsification:
1.The free energy of the conventional emulsion is a direct
function of the energy required to create a new surface between
the oil and water phases
2.In emulsification process the free energy (∆G)
associated is given by the equation:

12. • Where, ΔG=Free energy associated with the process.
N=No. of droplets of radius r.
σ=Represents interfacial energy
3. The two phases of emulsion tend to separate with
time to reduce the interfacial area, and subsequently,
the emulsion is stabilized by emulsifying agents.

13. Applications:
1.Improvement of solubility and bioavailability .
2.Protection against biodegradation.

14. Evaluation of SEDDS
1. Thermodynamic Stability Studies
2. Dispersibility test
3. Turbidimetric Evaluation
4. Viscosity Determination
5. Droplet Size Analysis and Particle Size Measurement
6. Refractive Index and Percent Transmittance
7. Electro Conductivity Study
8. In vitro Diffusion Study
9. Drug Content
10. In vivo permeability studies

15. Conclusion
Self‐emulsifying drug delivery systems are a promising
approach for the formulation of drug compounds with
poor aqueous solubility. The oral delivery of hydrophobic
drugs can be made possible by SEDDSs, which have been
shown to substantially improve oral bioavailability. With
future development of this technology, SEDDSs will
continue to enable novel applications in drug delivery
and solve problems associated with the delivery of
poorly soluble drugs.

16. THANK YOU