It is presentational slide for Medical students 1st year the Medical Biochemistry. This slide provides information about Enzymes and their Clinical Significance.......

1. Presented By: Muhammad Bin Asim ( B.S. Medical
Laboratory Sciences 2nd Semester )
Roll No: 015
Submitted To: Dr Aftab Alam
Dated: 25/05/2023

2.  Pancreatic Lipase is an enzyme produced by
the pancreas.
 It plays a crucial role in the Digestion and
Absorption of Dietary fats.
 It is secreted into the small intestine where it
acts on TGs, Breaking them into free fatty acids
and MGs, which can be easily absorbed by the
body.

3.  Acute Pancreatitis: Lead to reduce pancreatic
lipase production and subsequent fat malabsorption.
 Pancreatic Exocrine Insufficiency(PEI): Occurs
when the pancreas fails to produce an adequate
amount of pancreatic enzymes.
 Cystic Fibrosis(CF): Thickened mucus blocks the
pancreatic ducts, impairing the release of pancreatic
enzymes.

4.  Pancreatic Amylase is an enzyme produced by
the pancreas.
 It plays a crucial role in the digestion of
carbohydrates.
 It breaks down the complex carbohydrates into
smaller sugar molecules such as Glucose

5.  Chronic Pancreatitis: Increases pancreatic amylase
levels and lead to progressive damage of organ.
 Pancreatic Duct Obstruction: Lead to impaired
secretion of pancreatic enzymes due to blockage or
narrowing of duct.
 Pseudocysts: Can lead to elevated pancreatic
amylase levels.

6.  Refers to a group of enzymes.
 Responsible for the breakdown of the
neurotransmitter acetylcholine in the body.
 Two types ; Acetylcholinesterase (AChE) ,
Butyrylcholinesterase (BChE).
 AChE is found in the nervous system.
 BChE is found in the plasma and other tisses
throughout the body.

7.  Alzheimer’s Disease: Characterized by the
progressive loss of memory and cognitive functions.
 Myasthenia Gravis: Caused by antibodies
attacking the acetylcholine receptors at the
neuromuscular junction. Leading to muscle weakness
and fatigue.
 Organophosphate and Carbamate poisoning:
Inhibit the cholinesterase activity.

8.  GGT stands for Gamma-Glutamyl Tranferase.
 An enzyme found in various tissues
throughout the body.
 Has highest concentration in Liver.
 Plays a role in metabolism of Glutathione.

9.  GGT is commonly measured as a part of LFT.
 Access the overall health and functions of Liver.
 An elevated level of GGT in blood can indicate liver
disease or damage.
 GGT elevation can cause by excessive alcohol
consumption, obesity, certain medications, and other
liver diseases.

10.  G6PD stands for Glucose-6-phosphate
Dehydrogenase.
 It is an enzyme found in red blood cells.
 Plays a crucial role in protecting red blood cells
from oxidative damage.
 Help them by producing a substance called
reduced Glutathione.

11.  G6DP lies in its association with a genetic
condition called glucose-6-phosphate
dehydrogenase deficiency.
 It is an inherited disorder that effects red blood
cells.
 G6DP deficiency can lead to a condition known
as Hemolytic Anemia, where red blood cells
breakdown easily than normal