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Medical Discussion of the Endocannabinoid System

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In this lecture, given in Evansville, IN, on April 22nd, Dr. Cady reviews the scientific rersearch on the endocannabinoid system and the rationale for appropriately using it as a nmodality to optimize the structure and function of the body. This is a NON-BRANDED presentationb, and deals ONLY with the "ECS."

Published in: Health & Medicine
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Medical Discussion of the Endocannabinoid System

  1. 1. Louis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness InstituteLouis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness Institute Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Functional & Integrative Medicine – Evansville, Indiana Hemp Oil: What Can It Do For You? August 22, 2018 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  2. 2. A note for the viewer – please read carefully. • The slide presentation in this “deck” was presented as an educational lecture on April 6, 2018 in Evansville, Indiana. I have had several requests for the slides. • All slides in this deck should be looked at as informational ONLY. Any benefit for the use of these products is ONLY due to their ability to support the structure and function of the human body. • This deck may not be downloaded, stored, or modified in any way whatsoever. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  3. 3. Getting high on cannabis makes you less likely to work hard for money, study says – The Independent Sept 1, 2016 So why did God put a receptor for THC in our brains? This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  4. 4. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  5. 5. Eliassen AH, et al. Circulating Carotenoids and Risk of Breast Cancer: Pooled Analysis of Eight Prospective Studies. J Natl Cancer Inst. 2012 Dec 19;104(24):1905-16. doi: 10.1093/jnci/djs461. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  6. 6. MVI – supports the structure & function • B12 - 1,000% (as 60 MICROgrams cyanocobalamin) • B6 - 500% • Folic acid/folate - 150% • Magnesium 76% (as 300 Mg amino acid chelate) • Zinc 100% (15 mg as zinc chelate) • Selenium 200% (L-selenomethionine & NaSeO3) • Iodine 76% • Chromium 166% blood sugar control! • Vitamin C 834% • Vitamin A 300% (83% as Beta carotene and plant extracts • Vitamin E 666% (200 IU Vitamin E, d-alpha tocopherol, tocotrienols HOMOCYSTEINE LOWERING MOOD IMPROVING Testosterone raising! Boosts thyroid production!
  7. 7. • Raphael Mechoulam, Ph.D. • Professor of Medicinal Chemistry at Hebrew University of Jerusalem • He/research group chemically synthesized all of the major plant cannabinoids ( delta-9TCH, cannabidiol, cannabigerol • First isolation of the first endocannabinoid – Anandamide • 2-AG was soon discovered by Shimon Ben-Shabat, one of his Ph.D. students. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  8. 8. History of Cannabidiol, Endocannabinoid system, etc. • Hashish I. The structure of cannabidiol – Mechoulam, Shvo, 1963 • Hashish. IV. The isolation and structure of cannabinolic and cannabigerolic acids. 1964 • Delta-9 THC was synthesized. 1965 • “The effect of cannabidiol on mouse hepatic microsomal anandamide metabolism. 1993 – first paper on “endocannabinoid system.”This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  9. 9. “Clinical endocannabinoid deficiency (CECD) can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, IBS, and other treatment resistant conditions?” • Yes! • First published by EB Russo in 2004 • “Migraine, fibromyalgia, IBS, and related conditions…suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.” Neuro Endocrinol Lett. 2004 Feb-Apr;25(1-2):31-9. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  10. 10. 4,382 results – Feb 2, 2018 6:26 am4,382 results – Feb 2, 2018 6:26 am This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  11. 11. 4,591 results – August 19, 20184,591 results – August 19, 2018 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  12. 12. Study: evaluate CB1 ligands + other agents “that possess antidepressant potential.” CONCLUSIONS: “The simultaneous modulation of the cannabinoid system and supplementation of magnesium or zinc produce at least additive antidepressant-like effect.” Study: evaluate CB1 ligands + other agents “that possess antidepressant potential.” CONCLUSIONS: “The simultaneous modulation of the cannabinoid system and supplementation of magnesium or zinc produce at least additive antidepressant-like effect.”This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  13. 13. The results of the present study suggest that CB1r, CB2r, and MAGL are closely related to the neuropathological processes of PD. Therefore, the pharmacological modulation of these targets could represent a new potential therapeutic tool for the management of PD. The results of the present study suggest that CB1r, CB2r, and MAGL are closely related to the neuropathological processes of PD. Therefore, the pharmacological modulation of these targets could represent a new potential therapeutic tool for the management of PD. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  14. 14. Smith SC. Neuro Endocrinol Lett. 2014;35(3):198-201. Smith SC. Neuro Endocrinol Lett. 2014;35(3):198-201. CONCLUSION: Subsequent research has confirmed that underlying endocannabinoid deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome and a growing list of other medical conditions. Clinical experience is bearing this out. Further research and especially, clinical trials will further demonstrate the usefulness of medical cannabis. As legal barriers fall and scientific bias fades this will become more apparent. CONCLUSION: Subsequent research has confirmed that underlying endocannabinoid deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome and a growing list of other medical conditions. Clinical experience is bearing this out. Further research and especially, clinical trials will further demonstrate the usefulness of medical cannabis. As legal barriers fall and scientific bias fades this will become more apparent. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  15. 15. SEVERAL INTERVENTIONS UPREGULATE THE ECS SYSTEM: •Analgesics, anti-inflammatories •Antidepressants, antipsychotics, anxiolytics, anticonvulsants •Massage and manipulation •Acupuncture •Dietary supplements and herbal medicines. SEVERAL INTERVENTIONS UPREGULATE THE ECS SYSTEM: •Analgesics, anti-inflammatories •Antidepressants, antipsychotics, anxiolytics, anticonvulsants •Massage and manipulation •Acupuncture •Dietary supplements and herbal medicines. McPartland JM et al. PLoS One. 2014, Mar 12;9(3):e89566 McPartland JM et al. PLoS One. 2014, Mar 12;9(3):e89566 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  16. 16. Way back in April 14-15, 1912 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  17. 17. Purdue University & Mr. Fred A. Miler, botanist to Eli Lilly & Co. partner for “medicinal extract of Hemp (CBD) Research,” c. 1912-13 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  18. 18. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  19. 19. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  20. 20. Hemp • One of the oldest known cultivated plants • 12,000 years of usage • Used for clothes, soap and rope • Has a wide array of nutrients in it of almost all sources. • Medicinal use: 6,000 years • 3rd most prescribed medicinal agent for 60 years prior to its prohibition in 1937This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  21. 21. Cannabis SATIVA - HEMP Cannabis SATIVA - HEMP Cannabis SATIVA subspecies INDICA AND SEX DOESN’T MATTER!! This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  22. 22. Endogenous cannabinoids • Synthesized in OUR body: ENDOcannabinoids – 2-AG (2-arachidonylgylerol) – Anadamide (N-arachidonoylethanolamine “AEA”) • These are fatty acid neurotransmitters • 2-AG – most abundant endocannabinoid in the body • Regulates appetite, immune function, pain signals, energy storage, among others. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  23. 23. Endocannibinoid system – the body’s primary tool of homeostasis • Most significant neurotransmitter system in the body • Regulates & balances: – Nerve function, stress recovery, inflammation levels, immune function, energy intake and storage, cell life- cycles/apoptosis/reproduction, circulatory system This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  24. 24. The endocanninoid receptors by the numbers…• CB1 – Brain spinal cord, reproductive & connective tissues • CB2 – Modulates immune system. Found on spleen, tonsils, thymus, all white blood cells (receptors) • T cells, B-eta cells, macrophages • GPR55 – linked to bone development and cancer cell proliferation This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  25. 25. Endocannabinoids 101 • YOU make ENDO-cannabinoids – 2-AG (2 arachidonoylglycerol) • Most abundant • Regulates appetite, immune function, pain signals, energy storage. – Anandamide (N-arachidonoylethanolamine “AEA”) • HEMP plant makes PHYTO-cannabinoids – Interacts well with human CB receptors. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  26. 26. Anandamide • From Sanskrit for “bliss” or “happiness.” • Regulates pleasurable activities – food intake, reproduction, sleep, and pain relief • Found in mother’s milk, chocolate, and release during ovulation • Produced during meditation, yoga, and causes RUNNER’S HIGH. • A “bridge” between mind and body.This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  27. 27. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  28. 28. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  29. 29. • Circulating eCB’s in humans, dogs, and ferrets measured before and after treadmill exercise. • “We show that humans and dogs shaire significantly increased exercise-induced eCB signaling following high-intensity endurance running. • eCB’s are “a neurobiological reward for endurance exercise.” This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  30. 30. CECD: Clinical endocannabinoid deficiency • Implicated in many hard-to-treat disease states: – Fibromyalgia – Chronic migraines – Depression/anxiety – Irritable bowel syndrome Russo EB. Neuro End Lett 2008 April; 29(2): 192-200. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  31. 31. 60 citations 08 19 2018 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  32. 32. 57 citations 04/06/ 2017“Deficits in signaling mediated by the endocannabinoid 2-AG have been reported in mouse models of autism spectrum disorder.” “Deficits in signaling mediated by the endocannabinoid 2-AG have been reported in mouse models of autism spectrum disorder.” “Deficits in social interaction, excessive grooming, decreased exploration of environment...” “Deficits in social interaction, excessive grooming, decreased exploration of environment...” “MOA” – “increased glutamatergic drive, which is consistent with a loss of retrograde feedback inhibition.” “MOA” – “increased glutamatergic drive, which is consistent with a loss of retrograde feedback inhibition.” This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  33. 33. B “Endocannabinoid deficiency syndrome” – 2001 •“In certain conditions, whether congenital or acquired, endocannabinoid tone becomes deficient and productive of pathophysiological syndromes.” •many brain disorders are based on deficient neurotransmitters. “Endocannabinoid deficiency syndrome” – 2001 •“In certain conditions, whether congenital or acquired, endocannabinoid tone becomes deficient and productive of pathophysiological syndromes.” •many brain disorders are based on deficient neurotransmitters. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  34. 34. 19 results August 10, 201819 results August 10, 2018 • Stimulating ECS: • Reduction in alcohol consumption with +ECS input • Antihyperalgesic activities of EC in Mouse Model of neuropathic pain • Effects in migraine, fibromyalgia, irritable bowel, and “other treatment-resistant syndromes” (Russo EB, 2016) • CB2 deficient mice have pro-inflammatory obesity • Stimulating ECS: • Reduction in alcohol consumption with +ECS input • Antihyperalgesic activities of EC in Mouse Model of neuropathic pain • Effects in migraine, fibromyalgia, irritable bowel, and “other treatment-resistant syndromes” (Russo EB, 2016) • CB2 deficient mice have pro-inflammatory obesity
  35. 35. “Ethan B. Russo's paper of December 1, 2003 explored the concept of a clinical endocannabinoid deficiency (CECD) underlying the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome and other functional conditions alleviated by clinical cannabis.” “Ethan B. Russo's paper of December 1, 2003 explored the concept of a clinical endocannabinoid deficiency (CECD) underlying the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome and other functional conditions alleviated by clinical cannabis.”“Subsequent research has confirmed that underlying endocannabinoid deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome and a growing list of other medical conditions.” “Subsequent research has confirmed that underlying endocannabinoid deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome and a growing list of other medical conditions.” Smith SC, Wagner MS. Neuro Endocrinol Letter. 2014;35(3):198-201.
  36. 36. Bluett RJ. Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation. Transl Psych 2014 Jul 8;4:e 408 • Pharmacological augmentation of central endogenous cannabinoid (eCB) signaling may be an effective therapeutic strategy to mitigate the adverse behavioral and physiological consequences of stress. • These studies provide further support that eCB- augmentation is a viable pharmacological strategy for the treatment of stress-related neuropsychiatric disorders. • Pharmacological augmentation of central endogenous cannabinoid (eCB) signaling may be an effective therapeutic strategy to mitigate the adverse behavioral and physiological consequences of stress. • These studies provide further support that eCB- augmentation is a viable pharmacological strategy for the treatment of stress-related neuropsychiatric disorders. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  37. 37. statistically significant differences in cerebrospinal fluid anandamide levels have been documented in migraineurs, and advanced imaging studies have demonstrated ECS hypofunction in post-traumatic stress disorder. Additional studies have provided a firmer foundation for the theory, while clinical data have also produced evidence for decreased pain, improved sleep, and other benefits to cannabinoid treatment and adjunctive lifestyle approaches affecting the ECS. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  38. 38. Inflammation and CBD • CBD tested on mice that had a version of RA – CBD reduced mouse inflammation by 50% at correct dosage – Malfait AM et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen- induced arthritis. PNAS vol 97 no 17, 9561-9566 • one dosage of CBD immediately following a heart attack can reduce infarct size by c. 66% – Durst R et al. Am J Physiol Heart Circ Physiol.2007Dec;293(6): H3602-7.This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  39. 39. B These data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous prolactin action at the level of prolactin receptor. These data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous prolactin action at the level of prolactin receptor.This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  40. 40. B Both endocannabinoids exhibited neuroprotective activity at LOWER dose, but were neurotoxic at higher dose. Both endocannabinoids exhibited neuroprotective activity at LOWER dose, but were neurotoxic at higher dose. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  41. 41. B CONCLUSIONS. This data shows that acute administration of CBD reduces resting BP and the BP increase to stress in humans, associated with increased HR. CONCLUSIONS. This data shows that acute administration of CBD reduces resting BP and the BP increase to stress in humans, associated with increased HR. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  42. 42. What does the literature say about… • Pain • Sleep • Anxiety • Seizures • IBS • ADHD This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  43. 43. “Endocannabinoids, a group of less well--known endogenous bioactive lipids ... [are] able to influence both inflammation and pain.” This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  44. 44. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  45. 45. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  46. 46. • are under circadian control • promote non-rapid eye movement sleep • promote REM by interacting with melanin- concentrating hormone neurons • restores sleep in a model of insomnia in rats Endocannabinoids sleep – 107 citations 8/22/2018 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  47. 47. • cannabidiol (CBD), while representing a less specific pharmacological approach, may be another way to modulate eCBs and interacting neurotransmitter systems to alleviate anxiety. Endocannabinoids anxiety– 324 citations 8/22/2018 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  48. 48. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  49. 49. CONCLUSIONS: Our findings demonstrate that the deletion of Dagla [dacylgerol lipase alpha (DAGLalpha)] adversely affects the emotional state of animals and results in enhanced anxiety, stress, and fear responses. CONCLUSIONS: Our findings demonstrate that the deletion of Dagla [dacylgerol lipase alpha (DAGLalpha)] adversely affects the emotional state of animals and results in enhanced anxiety, stress, and fear responses. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  50. 50. Seizures “These data suggest the need for developing novel treatments using compounds that selectively target individual elements of the endocannabinoid signaling system. “These data suggest the need for developing novel treatments using compounds that selectively target individual elements of the endocannabinoid signaling system. 93 citations on “endocannabinoid system epilepsy” – 8/22/2018lsdkfj This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  51. 51. Endocannabinoid system and IBS Hasenoehri C et al. The gastrointestinal tract – a central organ of cannabinoid signaling in health and disease. Neurogastroenterol. Motil. 2016 Dec; 28(12):1765-1780. “Cannabinoid receptors and their endogenous ligands, the endocannabinoids, participate in the regulation of GI motility, secretion, and the maintenance of the epithelial barrier integrity.” “Cannabinoid receptors and their endogenous ligands, the endocannabinoids, participate in the regulation of GI motility, secretion, and the maintenance of the epithelial barrier integrity.” Endocannabinoid system irritable bowel syndrome – 238citations - 8/22/2018 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  52. 52. ADHD & the Endocannabinoid System • 18 citations in literature – 8/22/2018 – “adults with ADHD may represent a subgroup of individuals who experience a reduction of symptoms and no cognitive impairments following cannabinoid use.” • Cooper RE et al. Eur Neuropsychopharmacol. 2017 Aug; 27(8):795-808 This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  53. 53. • 30 adults with ADHD, placebo controlled study • Sativex Oromucosal spray was used. • “Adults with ADHD may represent a sub-group of individuals who experience a reduction of symptoms and no cognitive impairments following cannabinoid use.” This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  54. 54. Bioavailability problems of commercial products • Commercial hemp oil – Not THC free. – Only 6% of what is ingested gets absorbed. – 90% is wasted. • micellized hemp oil* = 85% bioavailability – Onset of action drops from 1-2 hours down to 5 – 15 min. • ultra micellized hemp oil* = 94% bioavailability * Note = generic, non-branded products are cited This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  55. 55. Full Spectrum Hemp Oil NOT just CBD… • Cannabinoids • Terpenes • Flavonoids • Fatty Acids • Vitamins • Minerals 7
  56. 56. • Inhibits cancer cell growth • Neuroprotective • Grows bone • Reduces seizures/convulsions • Reduces inflammation • Relieves pain/anxiety • Tranquilizing This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  57. 57. Micellation This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  58. 58. Study of one hemp oil at Mayo Clinic • N = 20 • Up to 94% absorption of cannabinoids in 12 hours – 10.9 mg of CBD in the hemp oil – - 8.3 mg back in the blood • Blood drawn every 15 minutes and then hourly out to 11 hours • 50% of this hemp oil was in the body in about 20 minutes. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  59. 59. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  60. 60. • 2000 inappropriate online health claims; 1000 still online • www.truthinadvertising.org , 2017 • 158 direct selling companies • 62 sell nutritional supplements • 60/62 (97%) have made health claims that... • “their products can diagnose, treat, cure, prevent, or alleviate the symptoms of and/or reduce the risk of developing a multitude of diseases.” This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  61. 61. Obligatory disclaimer. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. https://extranet.securefreedom.com/Zilis/Personal/Resources/ZilisComplianceTraining.pd f This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  62. 62. Personal collection Louis B. Cady, M.D. This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  63. 63. Thank you for coming! This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.
  64. 64. Contact information: Louis B. Cady, M.D. www.cadywellness.com Office: 812-429-0772 E-mail: lcady@cadywellness.com For appointments: info@cadywellness.com 4727 Rosebud Lane – Suite F Interstate Office Park Newburgh, IN 47630 (USA) This slide deck is not approved by the FDA. No Zilis product can be represented to treat, prevent, mitigate, or cure any disease. They are used ONLY for the structure and support of the body – specifically, the endocannabinoid system.

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