WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients

1. Paola Gómez Ávila
Laura Herrera Almanza
Semestre III
UPB

2. INTRODUCTION: GLIOMA

3. INTRODUCTION: GLIOMA

4. INTRODUCTION: MALIGNANT GLIOMA

5. INTRODUCTION: MALIGNANT GLIOMA

6. INTRODUCTION: MALIGNANT GLIOMA

7. INTRODUCTION: WTAP
Wilms'
tumor 1-
associating
protein
(WTAP)

8. INTRODUCTION: WTAP

9. INTRODUCTION: WILMS’ TUMOR

10. INTRODUCTION

11. Determine the association of the expression of
WTAP in patients with gliomas and its
significance in the prognosis of cancer.
GENERAL OBJETIVE

12. MATERIALES Y MÉTODOS: Pacientes

13. MATERIALES Y MÉTODOS: Pacientes

14. MATERIALES Y MÉTODOS: Pacientes

15. WESTERN BLOT

16. ENSAYO INMUNOHISTOQUÍMICO

17. ENSAYO INMUNOHISTOQUÍMICO

18. RESULTADOS

19. RESULTADOS

20. RESULTADOS

21. RESULTADOS

22. DISCUSSION
AUTHOR
Penalva et al. 2000;
Small et al. 2006
WTAP is a highly conserved protein that partners
with WT1 to function as a switch gene, regulating
the balance between quiescence and proliferation.
Diaz-Miqueli and Martinez
2013
In the past decades, despite the recognized
treatment for patients with gliomas is surgery
followed by chemotherapy and radiotherapy,
especially for the patients with high-grade gliomas,
therapeutic failure and disease progression are still
quite frequent

23. DISCUSSION
AUTHOR
Jin et al. 2012; Small et al.
2007
Du-Il Jin found that WTAP expression was greater
in GBM than in normal brain tissues and WTAP
could regulate proliferation, migration, and invasion
of GBM cell lines.
Finkel et al. 2007; Music et al.
2016; Yang et al. 2015; Zeng et
al.2016.
In other prognostic research, age and glioma grade
were demonstrated to be an independent
prognostic factor and as it is known that the
in-cidence rates increases with age for most
cancers including gliomas.

24. *A correlation between expression WTAP and patient survival is evident, in this case WTAP is a negative
prognostic factor. Increasing WTAP is associated with decreased survival of patients.
*Mortality in gliomas leads to the investigation of methods for tumor diagnosis and prognosis based on
biomarkers to develop better treatment and early diagnosis. WTAP expression in glioma indicate that it
could serve as a new prognostic marker and provide more options to improve treatment.
*Overexpression of WTAP is closely related with glioma grade.
*WTAP expression, age, glioma grade and ECOG are associated with survival of patients.
CONCLUSION

27. 1. Bio-radcom. 1. Bio-radcom. [Online]. Available from:
http://www.bio-rad.com/es-co/applications-technologies/introduction-western-blotting [Accessed 12 September 2016].
2. Rsnaorg. 2. Rsnaorg. [Online]. Available from: http://pubs.rsna.org/doi/ref/10.1148/radiol.2223010558 [Accessed 12 September
2016].
3. Cshlporg. 3. Cshlporg. [Online]. Available from: http://genesdev.cshlp.org/content/15/11/1311/F2.expansion.html [Accessed 12
September 2016].
4. Webmdcom. 4. WebMD. [Online]. Available from: http://www.webmd.com/cancer/brain-cancer/malignant-gliomas [Accessed 12
September 2016].
5. Abtaorg. 5. Abtaorg. [Online]. Available from:
http://www.abta.org/brain-tumor-information/types-of-tumors/glioma.html?referrer=https://www.google.com.co/[Accessed 12
September 2016].
6.
BIBLIOGRAFIA