Dolen & Malenka 2013
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The document discusses research on the neuropeptide oxytocin and its role in pair-bonding behaviors in prairie voles through its actions in the nucleus accumbens. Specifically, it summarizes findings that oxytocin signaling is required for social conditioned place preference in mice. Oxytocin induces long-term depression of synaptic transmission onto medium spiny neurons in the nucleus accumbens through presynaptic oxytocin receptors located on serotonin neurons in the dorsal raphe nucleus that project to the nucleus accumbens. Blocking serotonin 1B receptors in the nucleus accumbens also prevents social conditioned place preference.
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Dolen & Malenka 2013
- 1. Kristen Delevich Journal Club 10/15/13
- 2. OTR and pair-bonding 125I-OTA binding Photo: Todd Ahern/Emory University/via the San Francisco Chronicle Prairie vole Insel and Shapiro 1992 Montane vole
- 4. How to make love like a prairie vole?? Kimberly A. Young, Kyle L. Gobrogge, Yan Liu, Zuoxin Wang 2011
- 5. Love and other drugs photograph copyright JeanLouis Klein and Marie-Luce Hubert
- 6. Complex role of Oxytocin signaling 2012 2013
- 7. Do OTergic hypothalamic inputs to NAc even exist in male mice?
- 8. Male mice receive substantial OTergic input from PVN but not SON
- 9. Oxytocin is required for social CPP
- 10. NAc delivery of OT-A sufficient to block social CPP
- 11. Cocaine-induced CPP doesn’t require Oxytocin
- 12. Oxytocin induces LTD onto NAcc MSNs Allen Brain Atlas
- 13. Social housing engages OT-LTD, OT-LTD targets D1 & D2 NAc MSNs
- 14. Oxytocin-induced LTD is presynaptic
- 15. Selective ablation of OTRs in cOTR mice AAV-Cre Rabies-Cre
- 16. Presynaptic OTRs are required for social CPP
- 18. Ruling out vSub and ACC
- 19. Dorsal-raphe presynaptic OTRs necessary for social CPP and OT-LTD
- 20. NAc projecting dorsal raphe neurons are serotonergic
- 21. 5HT1RB agonist 5HT1RB agonist + OT antag. 5HT1RB antag. + OT OT-LTD acts through 5HTR1B
- 22. 5HTR1B antagonist in NAc blocks social CPP
- 24. Mechanism? 2009
Editor's Notes
- In general partner preference formation is mediated through AVP neurotransmission in the ventral pallidum and lateral septum in males, and oxytocin in the Nacc and prelimbic cortex in females.For females, overexpression of OTR in Nacc facilitates partner preference in absence of matingBesides pair-bonding OT and AVP implicate I range of social behaviors, including social recognition, aggression and maternal care.
- Implicated circuit for drug addiction but clearly evolved to motivate useful behaviors.GulDolen: Social behaviors in mice (right): Mice live in consociate “demes” consisting of five to ten adult members that share territorial defense and alloparental responsibilities as well as exhibit a number of behaviors (e.g. vocal communication, imitation, and empathy) that are the hallmarks of sociality
- Also proof of principal for target-specific synaptic modulation by OT, before some may have thought there was only paracrine signaling.
- Social experience reduces LTD, consistent with the idea that social experience induces OT LTD on its own
- Previous paper using OTR venus reporter mouse found 50% colocalization in the dorsal raphe
- Direct infusion of OT into dorsal raphe facilitated serotonin release