1. Altering the Site of Interrogation to
Increase the Quality of Non-Invasive
Blood Analysis
Katherine Paseman
2. Goal: Measure more Physical
Properties of Blood
Physical Medical Example
Property of Diagnostic Malady
Blood (Symptom)
Fluorescence Zinc Protoporphyrin Iron Deficient
(ZPP) Concentration Anemia, Lead
Poisoning
Absorption Hemoglobin Anemia
Concentration
Scattering Hematocrit Low- Blood loss,
High - Dehydration
3. Prior Non-Invasive Blood Analysis
Work: Pulse Oxcimetry
Used to non-invasively
determine Pulse and Blood
Oxygenation.
Oxygenation determined
using Time dependent
behavior
Red (660nm), Infrared (940
nm) -> Finger ->
Photodiode
Webster, JG. Design of Pulse Oxcimeters
4. Prior Work: Massimo pt 1
Most non-invasive blood λ lambda Hb02 Hb
nm cm-1/M cm-1/M
sensors (e,g, Masimo) extend
the pulseoximeter’s differential
610 610 1506 9443.6
absorption trick. Like the
pulseoximeter, they target the 620 620 942 6509.6
finger using wavelengths above 630 630 610 5148.8
600 nm, the so called ”Medical 660 660 319.6 3226.56
Spectral Window”, to collect 700 700 290 1794.28
enough light.
730 730 390 1102.2
805 806 844 730.28
905 906 1209.2 769.8
6. Prior Work: Samsung pt 1
Samsung’s attempt to use lower λ lambda Hb02 Hb
wavelengths produced this nm cm-1/M cm-1/M
comment:
G Yoon <gyoon@snut.ac.kr> -
569nm is highly absorbing in 569 570 44496 45072
tissue and, at the same time,
569nm intensity is small 660 660 319.6 3226.56
compared with that at longer
wavelength. That is why you
may not get good signal. We 805 806 844 730.28
used a custom-made LED array
that has several chips of 569nm 940 940 1214 693.44
to increase intensity.
975 976 1144 389.288
8. Our Research: Target Thumb Webbing
for Absorption instead of Finger
Our idea is to extend the medical
spectral window by targeting the
thumb webbing for absorption
([Sabrina Paseman 2008] did
this for fluorescence)
Io = Ii 10 –2.303 ε(λ) c t /(64,500 g Hb/mole)
t – cm
c – g/liter (A typical value of c for
whole blood is 150 g Hb/liter.)
Our hypothesis is that we can get
better measurements than
Samsung with a wider spectrum
of wavelengths by offsetting the
increase in extinction coefficient
with the decrease in sample
thickness.
Note: Thumb Webbing also
transmits a pulse [Sabrina
Paseman 2012]
