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PORTAL
HYPERTENSION
BY:
DR.KIRAN MAINDALE
WHAT IS PORTAL VENOUS
PRESSURE?
 Portal pressure is pressure excerted by blood
on poratl vein.
 Normal portal pressure:5-10 mmhg.
 Portal hypertension
 Is defined as the elevation of the hepatic
venous pressure gradient to > 15mm Hg.
Portal venous system
Porta caval anastomosis
 1. lower third of
oesophagous
 2.paraumbilical
region
 3. lower end of
rectum
 4.retroperitoneal
region.
 5. bare area of liver
Two important factors exist in
the pathophysiology of portal
hypertension
 vascular resistance .
 blood flow.
investigation
 CBC
 LFT- SGPT
SGOT
ALKALINE PHOSPHATASE
SR. ALBUMINE.
 Endoscopy: OGD scoppy.
 Upper GI barium studies.
Mesasurement of portal
presuure
 Liver angiography
 Transhepatic portography
 Umbilical catheterization
(spleenoportography)
 Portal veinography
CLINICAL FEATURES
 • Abdominal wall veins: Prominent collateral
veins radiating from umbilicus are termed
caput medusa.
 A venous hum may be heard usually in the
region of xiphoid process or umbilicus.
 Spleenomegaly (Mild to moderate)
 Ascites
 • Anorectal varices
 • Fetor hepaticus
COMPLICATIONS
 Variceal bleeding
 Hepatic encephalopathy
 Ascites
 Congestive gastropathy
 Hypersplenism
 Iron deficiency anaemia
 Renal failure
TREATMENT
 Usually patient come with acute variceal bleeding,
so management includes;
 resuscitation-
1. Blood transfusion
2. Saline avoided
3. Ice water stomach wash
4. Rapid bowel clearing by enema
5. Cimetidine
6. Tpr bp monitoring
 Diagnosis- endoscopy
 Specific treatment-
1. Vasopressin- 20u in 100ml D5% for 20
min.then contious infusion
2. Propanolol
3. Iv somatostatin
4. Endoscopic variceal sclerosis.
• Paravariceal- for recurrent
• Intravariceal- for acute bleeding
• 2.5%sod. Morrhuate, ethanolamine oleate.
 Balloon tamponade
 Sengestaken-blakmore tube
 Gastric 300ml, oseophageal- 45ml
 Transhepatic visceral embolisation
 Percutaneous transhepatic portal vein
puncture cathetarisation and occlusion of left
gastric vein
Treatment of complication
 Shock-sedatives ,BT, resuscitation.
 Clotting problems- from liver damage,
thrombocytopenia inj. Vit-k.
 Encephalopathy-gastric lavage neomycin
,bowel wash.
 Liver failure- plenty of carbohydrate orally.
 Ascites- low salt diet, diuretics, tapping.
Surgical tratment
1. Transthorasic oesophagotomy:
2. Gasterotomy: stapplers
3. Boerema-crile operation
4. Milnes-walker operation
5. Tanners operation
6. Oesophagial transection with
paraoesophagial devascularisation
7. Endoscopic sclerotherapy.
 So in emergency above mentioned procedures
are done to arrest bleeding.
 These procedure dosent decrease portal
pressure.
 Transthorasic oesophagotomy:
Rt lat. Position
Incision on 8-9th rib
Rib resected to reach parital pleura
Lungs retracted forword
oesophagus was transected and resutured
Bleeder occluded in suture.
Scoring of Portal HTN
SHUNT OPERATIONS
 Decompressive Shunts
Decompression is considered second-line
treatment
 Reserved for patients who rebleed through
pharmacologic therapy and endoscopic
banding or whose varices remain “high risk.”
 1. Radiologically placed shunt—TIPS.
 2. Surgical shunts Total, Partial, and
Selective shunts
TRANSJUGULAR INTRAHEPATIC
PORTOSYSTEMIC SHUNT (TIPS
 Direct puncture of the internal jugular vein (IJV),
 passage of a catheter through the right atrium into
one of the major hepatic veins followed by a trans-
parenchymal puncture of the liver to cannulate the
portal vein.
 • The catheter is passed into the portal vein
 • The intraparenchymal track is then dilated and the
track stented with an expandable metal stent in the
10- to 12-mm-diameter range.
 • The technical success rate is high (>90%) with a
low procedural morbidity and mortality (<10%).
 • Patients are usually in the hospital for 1–2 days
and the shunt patency should be documented the
day after the procedure with a Doppler ultrasound.
Shunts
 Total Shunts
1. End-to-side portacaval shunt
2. Side to side portocaval shunt (diameter
>10mm)
 Partial shunts
1. Side to side portocaval shunt(diameter
<8mm)
 Selective shunts
1. Distal splenorenal shunt
 The only indication for a total portal systemic
shunt at present is for patients with acute
Budd- Chiari syndrome
Partial Shunts •
 Partial shunts are side-to-side shunts whose
diameter is reduced to 8 mm.
 • 90% control of variceal bleeding
 • polytetrafluoroethylene (PTFE) graft is
approximately 2–3 cm long, and beveled at
each end to give a larger anastomosis.
Selective Shunts
 • Selective shunts are most commonly the distal
splenorenal shunt (DSRS)
 • Divide the splenic vein at its junction with the superior
mesenteric vein, and anastomoses the splenic vein to
the left renal vein.
 • This selectively decompresses gastroesophageal
varices.
 • Control of bleeding has been at 94%, with good portal
perfusion maintained in 90% of patients initially.
 • The overall incidence of encephalopathy has been
around 15% following this operation.
THANK YOU !!!

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Portal hypertension by kiran maindale

  • 2. WHAT IS PORTAL VENOUS PRESSURE?  Portal pressure is pressure excerted by blood on poratl vein.  Normal portal pressure:5-10 mmhg.  Portal hypertension  Is defined as the elevation of the hepatic venous pressure gradient to > 15mm Hg.
  • 3.
  • 5. Porta caval anastomosis  1. lower third of oesophagous  2.paraumbilical region  3. lower end of rectum  4.retroperitoneal region.  5. bare area of liver
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  • 7. Two important factors exist in the pathophysiology of portal hypertension  vascular resistance .  blood flow.
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  • 13. investigation  CBC  LFT- SGPT SGOT ALKALINE PHOSPHATASE SR. ALBUMINE.  Endoscopy: OGD scoppy.  Upper GI barium studies.
  • 14. Mesasurement of portal presuure  Liver angiography  Transhepatic portography  Umbilical catheterization (spleenoportography)  Portal veinography
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  • 16. CLINICAL FEATURES  • Abdominal wall veins: Prominent collateral veins radiating from umbilicus are termed caput medusa.  A venous hum may be heard usually in the region of xiphoid process or umbilicus.  Spleenomegaly (Mild to moderate)  Ascites  • Anorectal varices  • Fetor hepaticus
  • 17. COMPLICATIONS  Variceal bleeding  Hepatic encephalopathy  Ascites  Congestive gastropathy  Hypersplenism  Iron deficiency anaemia  Renal failure
  • 18. TREATMENT  Usually patient come with acute variceal bleeding, so management includes;  resuscitation- 1. Blood transfusion 2. Saline avoided 3. Ice water stomach wash 4. Rapid bowel clearing by enema 5. Cimetidine 6. Tpr bp monitoring  Diagnosis- endoscopy
  • 19.  Specific treatment- 1. Vasopressin- 20u in 100ml D5% for 20 min.then contious infusion 2. Propanolol 3. Iv somatostatin 4. Endoscopic variceal sclerosis. • Paravariceal- for recurrent • Intravariceal- for acute bleeding • 2.5%sod. Morrhuate, ethanolamine oleate.
  • 20.  Balloon tamponade  Sengestaken-blakmore tube  Gastric 300ml, oseophageal- 45ml  Transhepatic visceral embolisation  Percutaneous transhepatic portal vein puncture cathetarisation and occlusion of left gastric vein
  • 21. Treatment of complication  Shock-sedatives ,BT, resuscitation.  Clotting problems- from liver damage, thrombocytopenia inj. Vit-k.  Encephalopathy-gastric lavage neomycin ,bowel wash.  Liver failure- plenty of carbohydrate orally.  Ascites- low salt diet, diuretics, tapping.
  • 22. Surgical tratment 1. Transthorasic oesophagotomy: 2. Gasterotomy: stapplers 3. Boerema-crile operation 4. Milnes-walker operation 5. Tanners operation 6. Oesophagial transection with paraoesophagial devascularisation 7. Endoscopic sclerotherapy.
  • 23.  So in emergency above mentioned procedures are done to arrest bleeding.  These procedure dosent decrease portal pressure.  Transthorasic oesophagotomy: Rt lat. Position Incision on 8-9th rib Rib resected to reach parital pleura Lungs retracted forword oesophagus was transected and resutured Bleeder occluded in suture.
  • 25. SHUNT OPERATIONS  Decompressive Shunts Decompression is considered second-line treatment  Reserved for patients who rebleed through pharmacologic therapy and endoscopic banding or whose varices remain “high risk.”  1. Radiologically placed shunt—TIPS.  2. Surgical shunts Total, Partial, and Selective shunts
  • 26. TRANSJUGULAR INTRAHEPATIC PORTOSYSTEMIC SHUNT (TIPS  Direct puncture of the internal jugular vein (IJV),  passage of a catheter through the right atrium into one of the major hepatic veins followed by a trans- parenchymal puncture of the liver to cannulate the portal vein.  • The catheter is passed into the portal vein  • The intraparenchymal track is then dilated and the track stented with an expandable metal stent in the 10- to 12-mm-diameter range.  • The technical success rate is high (>90%) with a low procedural morbidity and mortality (<10%).  • Patients are usually in the hospital for 1–2 days and the shunt patency should be documented the day after the procedure with a Doppler ultrasound.
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  • 28. Shunts  Total Shunts 1. End-to-side portacaval shunt 2. Side to side portocaval shunt (diameter >10mm)  Partial shunts 1. Side to side portocaval shunt(diameter <8mm)  Selective shunts 1. Distal splenorenal shunt
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  • 32.  The only indication for a total portal systemic shunt at present is for patients with acute Budd- Chiari syndrome Partial Shunts •  Partial shunts are side-to-side shunts whose diameter is reduced to 8 mm.  • 90% control of variceal bleeding  • polytetrafluoroethylene (PTFE) graft is approximately 2–3 cm long, and beveled at each end to give a larger anastomosis.
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  • 34. Selective Shunts  • Selective shunts are most commonly the distal splenorenal shunt (DSRS)  • Divide the splenic vein at its junction with the superior mesenteric vein, and anastomoses the splenic vein to the left renal vein.  • This selectively decompresses gastroesophageal varices.  • Control of bleeding has been at 94%, with good portal perfusion maintained in 90% of patients initially.  • The overall incidence of encephalopathy has been around 15% following this operation.
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