More Related Content
Similar to Autoimmune (20)
Autoimmune
- 15. CD4 cell activity increase Cytotoxic T Cells promed B cell activity Auto-antibodies Cytokines (delayed hyper- sensitivity re- action) Ag/Ab+complement CELL DESTRUCTION
- 16. ORGAN SPESIFIK Antibody or cell mediated reaction to Target organ Associated disease Thyroid cells and hormone or TSH receptor Thytroid Primary myxoedema,Hashimoto’s disease (autoimmune thyroiditis), Thyrotoxikosis (Graves’ disease) Parietal cells intrinsic factor/intrinsic factor B12 complex Stomach Pernicious anemia
- 17. SAMBUNGAN Red blood cells Red blood cells Haemolytic anemia Pancreatic islet beta cells Pancreas Type I diabetes Adrenal cortical cell, ACTH receptor Adrenal Addison’s disease Parathyroid cells Parathyroid Prymary hypoparathyroidism Acetylcholline receptor Voluntary muscle Myasthemia gravis
- 18. NON-ORGAN SPECIFIC Antibody to Target organ Associated Disease Mitochondria Liver Primary biliary cirrosis Smooth muscle Nuclear constituents IgG Many other body protein Liver Autoimmune chronic hepatis Skin and muscle The connective tissue disease, Dermatomyositis, Rhematoid arthritis, Systemic lupus erythematosus (SLE), Progressive systemic sclerosis Skin, kidney,endocardium, blood vessels, joints
- 28. TISSUE TRANSPLANTATION Antigen presenting Cell in graft Present “foreign” HLA antigen Cell mediated immunity Cytokines Rejevtion Host T cell Spesific T cell immune Respons to HLA antigen Cytotoxic T cells Attack graff cell (particularly vascular endothelium