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Bcr signaling and inhibition
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Model of B cell receptor signaling and clinical inhibition
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Bcr signaling and inhibition
1.
CD79 CD19 Syk PI3K Lyn Lyn BLNK BTK AKT MTOR MEK ERK CARD11 NF-kB BCR Signaling Survival GrowthMicroenvironment Proliferation
2.
CD79 CD19 Syk PI3K Lyn Lyn BLNK BTK AKT MTOR MEK ERK CARD11 NF-kB BCR Inhibition Survival GrowthMicroenvironment Proliferation •
Syk – Fostamatinib – GS-9973 • BTK – Ibrutinib – AVL-292 • PI3K – Idelalisib – Others