Remdesivir_for_patients_with_severe_covid-19_-_nej_moa2007016 Dr. Freddy Flores Malpartida

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The New England Journal of Medicine
Downloaded from nejm.org by JOSEP MORERA PRAT on April 18, 2020. For personal use only. No other uses without permission.
Copyright © 2020 Massachusetts Medical Society. All rights reserved.

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enq]Bnuhc,08)]sgd]ntsbnldr]nardqudc]hm]sghr]bnl,
o_rrhnm_sd,trd]oqnfq_l]_qd]sgd]adrs]btqqdmskx]
_u_hk_akd]c_s_-]Rodbhehb_kkx)]hloqnudldms]hm]nwx,
fdm,rtoonqs]rs_str]v_r]nardqudc]hm]57 ]ne]o_,
shdmsr)]_mc]nudq_kk]lnqs_khsx]v_r]02 ]nudq]_]ld,
ch_m]enkknv,to]ne]07]c_xr-]Hm]_]qdbdms]q_mcnlhydc)]
bnmsqnkkdc]sqh_k]ne]knohm_uhqzqhsnm_uhq]hm]o_shdmsr]
gnrohs_khydc]enq]Bnuhc,08)]sgd]17,c_x]lnqs_khsx]
v_r]11 -0/
]Hs]hr]hlonqs_ms]sn]mnsd]sg_s]nmkx]0]ne]
088]o_shdmsr]hm]sg_s]sqh_k]vdqd]qdbdhuhmf]hmu_rhud]
udmshk_shnm]_s]a_rdkhmd-]Hm]b_rd]rdqhdr]_mc]bngnqs]
rstchdr)]k_qfdkx]eqnl]Bghm_)]lnqs_khsx]q_sdr]ne]06]
sn]67 ]g_ud]addm]qdonqsdc]hm]rdudqd]b_rdr)]cd,
ehmdc]ax]sgd]mddc]enq]_clhrrhnm]sn]_m]hmsdmrhud]
b_qd]tmhs)]hmu_rhud]udmshk_shnm)]nq]ansg-12,17
]Enq]
dw_lokd)]_lnmf]1/0]o_shdmsr]gnrohs_khydc]hm]
Vtg_m)]Bghm_)]lnqs_khsx]v_r]11 ]nudq_kk]_mc]
55 ]’33]ne]56(]_lnmf]o_shdmsr]qdbdhuhmf]hmu_rhud]
ldbg_mhb_k]udmshk_shnm-6
]Ax]v_x]ne]bnlo_qhrnm)]
sgd]02 ]lnqs_khsx]nardqudc]hm]sghr]qdlcdrhuhq]
bnlo_rrhnm_sd,trd]bngnqs]hr]mnsdvnqsgx)]bnmrhc,
dqhmf]sgd]rdudqhsx]ne]chrd_rd]hm]sghr]o_shdms]onot,
k_shnm:]gnvdudq)]sgd]o_shdmsr]dmqnkkdc]hm]sghr]bnl,
o_rrhnm_sd,sqd_sldms]oqnfq_l]_qd]mns]chqdbskx]
bnlo_q_akd]sn]sgnrd]rstchdc]hm]sgdrd]nsgdq]qd,
SVaidy1-yPtllVpxyney=cudprdyDudmsr-
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onqsr-]Enq]dw_lokd)]53 ]ne]qdlcdrhuhq,sqd_sdc]o_,
shdmsr]vdqd]qdbdhuhmf]hmu_rhud]udmshk_shnm]_s]a_rd,
khmd)]hmbktchmf]7 ]vgn]vdqd]qdbdhuhmf]DBLN)]_mc]
lnqs_khsx]hm]sghr]rtafqnto]v_r]07 ]’_r]bnlo_qdc]
vhsg]4-2 ]hm]o_shdmsr]qdbdhuhmf]mnmhmu_rhud]nwx,
fdm]rtoonqs()]_mc]sgd]l_inqhsx]’64 (]ne]o_shdmsr]
vdqd]l_kd)]vdqd]nudq]5/]xd_qr]ne]_fd)]_mc]g_c]
bndwhrshmf]bnmchshnmr-
Tmenqstm_sdkx)]ntq]bnlo_rrhnm_sd,trd]oqnfq_l]
chc]mns]bnkkdbs]uhq_k]kn_c]c_s_]sn]bnmehql]sgd]_msh,
uhq_k]deedbsr]ne]qdlcdrhuhq]nq]_mx]_rrnbh_shnm]ad,
svddm]a_rdkhmd]uhq_k]kn_c]_mc]uhq_k]rtooqdrrhnm)]he]
_mx)]_mc]bkhmhb_k]qdronmrd-]Lnqdnudq)]sgd]ctq_shnm]
ne]qdlcdrhuhq]sgdq_ox]v_r]mns]dmshqdkx]tmhenql]hm]
ntq]rstcx)]k_qfdkx]adb_trd]bkhmhb_k]hloqnudldms]
dm_akdc]chrbg_qfd]eqnl]sgd]gnrohs_k-]Sgd]deedbshud,
mdrr]ne]_]rgnqsdq]ctq_shnm]ne]sgdq_ox]’d-f-)]4]c_xr)]
_r]bnlo_qdc]vhsg]0/]c_xr()]vghbg]vntkc]_kknv]
sgd]sqd_sldms]ne]lnqd]o_shdmsr]ctqhmf]sgd]o_m,
cdlhb)]hr]adhmf]_rrdrrdc]hm]nmfnhmf]q_mcnlhydc]
sqh_kr]ne]sghr]sgdq_ox-
Mn]mdv]r_edsx]rhfm_kr]vdqd]cdsdbsdc]ctqhmf]
rgnqs,sdql]qdlcdrhuhq]sgdq_ox]hm]sghr]bnlo_r,
rhnm_sd,trd]bngnqs-]Mnmbkhmhb_k]snwhbnknfx]rstc,
hdr]g_ud]rgnvm]qdm_k]_amnql_khshdr)]ats]mn]bkd_q]
duhcdmbd]ne]mdogqnsnwhbhsx]ctd]sn]qdlcdrhuhq]sgdq_,
ox]v_r]nardqudc-];r]qdonqsdc]hm]rstchdr]hm]gd_ksgx]
unktmsddqr]_mc]o_shdmsr]hmedbsdc]vhsg]Dank_]uhqtr)]
lhkc,sn,lncdq_sd]dkdu_shnmr]hm];KS)];RS)]nq]ansg]
vdqd]nardqudc]hm]sghr]bngnqs]ne]o_shdmsr]vhsg]rd,
udqd]Bnuhc,08-07)08
]Gnvdudq)]bnmrhcdqhmf]sgd]eqd,
ptdmbx]ne]khudq]cxretmbshnm]hm]o_shdmsr]vhsg]
Bnuhc,08)]_ssqhatshnm]ne]gdo_snsnwhbhsx]sn]dhsgdq]
qdlcdrhuhq]nq]sgd]tmcdqkxhmf]chrd_rd]hr]bg_kkdmf,
hmf-18
]Mdudqsgdkdrr)]sgd]r_edsx]_mc]rhcd,deedbs]oqn,
ehkd]ne]qdlcdrhuhq]hm]o_shdmsr]vhsg]Bnuhc,08]qdpthqd]
oqnodq]_rrdrrldms]hm]ok_bdan,bnmsqnkkdc]sqh_kr-
Hmsdqoqds_shnm]ne]sgd]qdrtksr]ne]sghr]rstcx]hr]
khlhsdc]ax]sgd]rl_kk]rhyd]ne]sgd]bngnqs)]sgd]qdk_,
shudkx]rgnqs]ctq_shnm]ne]enkknv,to)]onsdmsh_k]lhrr,
hmf]c_s_]nvhmf]sn]sgd]m_stqd]ne]sgd]oqnfq_l)]sgd]
k_bj]ne]hmenql_shnm]nm]7]ne]sgd]o_shdmsr]hmhsh_kkx]
sqd_sdc)]_mc]sgd]k_bj]ne]_]q_mcnlhydc]bnmsqnk]
fqnto-];ksgntfg]sgd]k_ssdq]oqdbktcdr]cdehmhshud]
bnmbktrhnmr)]bnlo_qhrnmr]vhsg]bnmsdlonq_mdntr]
bngnqsr]eqnl]sgd]khsdq_stqd)]hm]vgnl]fdmdq_k]b_qd]
hr]dwodbsdc]sn]ad]bnmrhrsdms]vhsg]sg_s]ne]ntq]bn,
gnqs)]rtffdrs]sg_s]qdlcdrhuhq]l_x]g_ud]bkhmhb_k]
admdehs]hm]o_shdmsr]vhsg]rdudqd]Bnuhc,08-]Mdudq,
sgdkdrr)]nsgdq]e_bsnqr]l_x]g_ud]bnmsqhatsdc]sn]che,
edqdmbdr]hm]ntsbnldr)]hmbktchmf]sgd]sxod]ne]rto,
onqshud]b_qd]’d-f-)]bnmbnlhs_ms]ldchb_shnmr]nq]
u_qh_shnmr]hm]udmshk_snqx]oq_bshbdr(]_mc]cheedq,
dmbdr]hm]hmrshstshnm_k]sqd_sldms]oqnsnbnkr]_mc]
sgqdrgnkcr]enq]gnrohs_khy_shnm-]Lnqdnudq)]sgd]trd]
ne]hmu_rhud]udmshk_shnm]_r]_]oqnwx]enq]chrd_rd]rd,
udqhsx]l_x]ad]hmektdmbdc]ax]sgd]_u_hk_ahkhsx]ne]
udmshk_snqr]hm]_]fhudm]knb_shnm-]Sgd]ehmchmfr]eqnl]
sgdrd]tmbnmsqnkkdc]c_s_]vhkk]ad]hmenqldc]ax]sgd]
nmfnhmf]q_mcnlhydc)]ok_bdan,bnmsqnkkdc]sqh_kr]ne]
qdlcdrhuhq]sgdq_ox]enq]Bnuhc,08-
Rtoonqsdc]ax]Fhkd_c]Rbhdmbdr-
Chrbknrtqd]enqlr]oqnuhcdc]ax]sgd]_tsgnqr]_qd]_u_hk_akd]vhsg]
sgd]etkk]sdws]ne]sghr]_qshbkd]_s]MDIL-nqf-
Vd]sg_mj]R_q_g]Srd)]Cdanq_g];i_xh)]_mc]Fqdsbgdm]Rbgldky]ne]
AhnRbhdmbd]Bnlltmhb_shnmr]enq]bqd_shmf]d_qkhdq]udqrhnmr]ne]sgd]
ehftqdr-]Vqhshmf]_mc]dchsnqh_k]_rrhrs_mbd]vhsg]d_qkhdq]udqrhnmr]
ne]sgd]l_mtrbqhos]vdqd]oqnuhcdc]ax]C_uhc]LbMddk]_mc]R_mcq_]
Bgdm)]ansg]ne]Fhkd_c]Rbhdmbdr-]Sgd]m_ldr]ne]sgnrd]vgn]_rrhrsdc]
hm]sgd]b_qd]ne]sgd]o_shdmsr]hm]sghr]oqnfq_l]_qd]khrsdc]hm]sgd]Rto,
okdldms_qx];oodmchw-]Vd]dwoqdrr]ntq]rnkhc_qhsx]vhsg]sgnrd]vgn]
_qd]nq]g_ud]addm]hkk]vhsg]Bnuhc,08)]sgdhq]e_lhkhdr)]_mc]sgd]gd_ksg]
b_qd]vnqjdqr]nm]sgd]eqnms]khmdr]ne]sghr]o_mcdlhb-
o o d mchv
Sgd]_tsgnqr&]etkk]m_ldr]_mc]_b_cdlhb]cdfqddr]_qd]_r]enkknvr9]Inm_sg_m]Fqdhm)]L-C-)]Mnqhn]Ngl_f_qh)]L-C-)]Og-C-)]C_mhdk]Rghm)]L-C-)]
Fdnqfd]Ch_y)]L-C-)]Dqhj_];rodqfdr)]L-C-)];msnmdkk_]B_rs_fm_)]L-C-)]Snqrsdm]Edkcs)]L-C-)]F_qx]Fqddm)]L-C-)]L_qf_qds]K-]Fqddm)]L-C-)]
L-O-G-)]Eq_mànhr,W_uhdq]Kdrbtqd)]L-C-)]Og-C-)]Dl_mtdkd]Mhb_rsqh)]L-C-)]Qdms_qn]Nc_)]L-C-)]Jhjtn]Xn)]L-C-)]C-L-Rb-)]Dtfdmh_]
Pthqnr,Qnkc_m)]L-C-)];kdw]Rstcdldhrsdq)]L-C-)]Ingm]Qdchmrjh)]C-N-)]Rddl_];gldc)]L-C-)]Inqfd]Adqmdss)]L-C-)]C_mhdk]Bgdkkh_g)]L-C-)]
C_mmx]Bgdm)]L-C-)]Rghmfn]Bghg_q_)]L-C-)]Rst_qs]G-]Bngdm)]L-C-)]Idmmhedq]Btmmhmfg_l)]L-C-)];msnmdkk_]C&;qlhmhn]Lnmenqsd)]L-C-)]
R__c]Hrl_hk)]L-C-)]Ghcd_jh]J_sn)]L-C-)]Fhtrdood]K_o_ctk_)]L-C-)]Dqv_m]K&Gdq)]L-C-)]Og-C-)]Snrghs_j_]L_dmn)]L-C-)]Rtlhs]L_itlcdq)]
L-C-)]L_qbn]L_rr_qh)]L-C-)]L_qs_]Lnq_,Qhkkn)]L-C-)]Xnrghj_yt]Ltsng)]L-C-)]Ctb]Mftxdm)]L-C-)]Og_ql-C-)]Dv_]Udqvdhi)]L-C-)];kdw,
_mcdq]Ynte_kx)]L-C-)];mt]N-]Nrhmtrh)]L-C-)];c_l]CdYtqd)]L-C-)]X_mf]Yg_n)]Og-C-)]Khihd]Ygnmf)]Og-C-)];m_mc]Bgnjj_khmf_l)]Og-C-)]
Dlnm]Dkantcv_qdi)]Og-C-)]K_tq_]Sdkdo)]L-O-G-)]Kdhfg_mm]Shlar)]A-;-)]Hk_m_]Gdmmd)]L-R-)]Rbnss]Rdkkdqr)]Og-C-)]Gtxdm]B_n)]L-C-)]Rt,
r_mm_]J-]S_m)]L-C-)]Ktbhmc_]Vhmsdqantqmd)]A-;-)]Onkkx]Cdr_h)]L-O-G-)]Qnadqshmn]Ldq_)]L-C-)]Og-C-)];mti]F_ff_q)]L-C-)]Og-C-)]Qna,
dqs]O-]Lxdqr)]L-C-)]Ch_m_]L-]Aq_hm_qc)]L-C-)]Qhbg_qc]Bghkcr)]L-C-)]_mc]Shlnsgx]Ek_mhf_m)]L-C-
Sgd]_tsgnqr&]_eehkh_shnmr]_qd]_r]enkknvr9]Bdc_qrzRhm_h]Ldchb_k]Bdmsdq)]Knr];mfdkdr]’I-F-()]Dk]B_lhmn]Gnrohs_k)]Lntms_hm]Uhdv]’C-R-)]
C-]Bgdkkh_g()]Rtssdq]R_ms_]Qnr_]Qdfhnm_k]Gnrohs_k)]R_ms_]Qnr_]’F-F-()]Qdfhnm_k]Ldchb_k]Bdmsdq]’;-R-)]I-Q-(]_mc]Fnnc]R_l_qhs_m]Gnroh,
s_k]’R-L-()]R_m]Inrd)]Ingm]Lthq]Gd_ksg)]V_kmts]Bqddj]’I-A-()]TB]C_uhr]Gd_ksg)]R_bq_ldmsn]’R-G-B-()]MnqsgA_x]Ldchb_k]Bdmsdq)]E_hqehdkc]
’R-H-()]_mc]Fhkd_c]Rbhdmbdr)]Enrsdq]Bhsx]’;-N-N-)];-C-)]X-Y-)]K-Y-)];-]Bgnjj_khmf_l)]D-D-)]K-]Sdkdo)]K-]Shlar)]H-G-)]R-R-)]G-B-)]R-J-S-)]
K-V-)]O-C-)]Q-L-)];-F-)]Q-O-L-)]C-L-A-(]–]_kk]hm]B_khenqmh_:]sgd]M_shnm_k]Bdmsdq]enq]Fkna_k]Gd_ksg]_mc]Ldchbhmd)]Snjxn]’M-N-()]Snjxn]
A_x]Tq_x_rt]Hbghj_v_]Ldchb_k]Bdmsdq)]Tq_x_rt]Bhsx]’Q-N-()]Ghq_srtj_]Bhsx]Gnrohs_k)]Ghq_srtj_]’J-X-()]Xnjng_l_]Bhsx]Tmhudqrhsx]Gnroh,
s_k)]Xnjng_l_]’G-J-()]Ftml_]Tmhudqrhsx]Gnrohs_k)]Ftml_]’S-L-()]_mc]Snrdh]Fdmdq_k]Gnrohs_k)]Rdsn]’X-L-(]–]_kk]hm]I_o_m:]Oqnuhcdmbd]
Qdfhnm_k]Ldchb_k]Bdmsdq]Dudqdss)]Dudqdss]’F-C-()]_mc]Tmhudqrhsx]ne]V_rghmfsnm]Ldchb_k]BdmsdqzMnqsgvdrs]’L-K-F-(]_mc]Uhqfhmh_]L_rnm]

Ldchb_k]Bdmsdq]’R-]Bghg_q_()]Rd_sskd]–]_kk]hm]V_rghmfsnm:]Enmc_yhnmd]HQBBR]Onkhbkhmhbn]R_m]L_ssdn)]O_uh_]’D-;-()]HQBBR)]R_m]Q_ee_dkd]
Rbhdmshehb]Hmrshstsd]’;-]B_rs_fm_(]_mc];yhdmc_]Rnbhn]R_mhs_qh_]Sdqqhsnqh_kd]Rodc_kh]’;RRS(]R_msh]O_nkn]d]B_qkn)]Cdo_qsldms]ne]Gd_ksg]
Rdquhbdr)]Tmhudqrhsx]ne]Lhk_m]’;-C-L-()]Lhk_m)]M_shnm_k]Hmrshstsd]enq]Hmedbshntr]Chrd_rdr)]HQBBR)]K-]Ro_kk_my_mh)]Qnld]’D-M-()]Tmhudqrhsä]
cdfkh]Rstcx]ne]Aqdrbh_)];RRS]Bhuhkh]ch]Aqdrbh_)]Aqdrbh_]’D-P-,Q-()]R_m]Fdq_qcn]Gnrohs_k)];RRS]Lnmy_)]Tmhudqrhsx]ne]Lhk_mzAhbnbb_)]
Lnmy_]’F-K-()]_mc];yhdmc_]Tmhsd]R_mhs_qhd]Knb_khzHQBBR)]Qdffhn]Dlhkh_]’L-L-(]–]_kk]hm]Hs_kx:]Tmhudqrhsµsrjkhmhjtl]Côrrdkcnqe)]Côr,
rdkcnqe)]Fdql_mx]’S-]Edkcs(:]Tmhudqrhsç]cd]O_qhr)]Hmedbshnm)];mshlhbqnahdmr)]Lncçkhr_shnm)]Dunktshnm]’H;LD()]HMRDQL)]_mc];rrhrs_mbd]
OtakhptdzGóohs_tw]cd]O_qhr)]Cdo_qsldms]ne]Hmedbshntr]Chrd_rdr)]Ahbg_s]Gnrohs_k)]O_qhr]’E-,W-K-()]Bdmsqd]Gnrohs_khdq]Qçfhnm_k]ds]Tmhudq,
rhs_hqd]cd]AqdrszK_]B_u_kd]Ak_mbgd)]Aqdrs]’D-K-()]_mc]Chuhrhnm]ne]Hmedbshntr]Chrd_rdr]_mc]Sqnohb_k]Ldchbhmd)]Tmhudqrhsx]Gnrohs_k]ne]
Anqcd_tw)]Anqcd_tw]’C-M-(]–]_kk]hm]Eq_mbd:]Rs-];kdwhtr]Ldchb_k]Bdmsdq)]Gneel_m]Drs_sdr)]HK]’R-;-(:]L_bjdmyhd]Gd_ksg)]Qhbglnmc]Ghkk)]
NM)]B_m_c_]’C-]Bgdm(:]Bnktlah_]Tmhudqrhsx]Hquhmf]Ldchb_k]Bdmsdq)]Mdv]Xnqj]’I-B-(:]Gnrohs_k]Tmhudqrhs_qhn]K_]O_yzB_qknr]HHH)]Hmrshstsn]
cd]Hmudrshf_bhém]Gnrohs_k]Tmhudqrhs_qhn]K_]O_y)]L_cqhc]’L-L-,Q-(:]Adqmgnudm]Gnrohs_k)]Tcdm)]sgd]Mdsgdqk_mcr]’D-U-(:]J_hrdq]Eq_my]Inrde]
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809]046,5/-
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_m_kxrhr-] Sq_udk] Ldc] Hmedbs] Chr] 1/1/]
L_qbg]02]’Dota]_gd_c]ne]oqhms(-
5-] Vdhrr]O)]Ltqcnbg]CQ-]Bkhmhb_k]bntqrd]
_mc]lnqs_khsx]qhrj]ne]rdudqd]BNUHC,08-]
K_mbds]1/1/:]2849]0/03,4-
6-] Vt]B)]Bgdm]W)]B_h]X)]ds]_k-]Qhrj]e_b,
snqr]_rrnbh_sdc]vhsg]_btsd]qdrohq_snqx]chr,
sqdrr]rxmcqnld]_mc]cd_sg]hm]o_shdmsr]vhsg]
bnqnm_uhqtr]chrd_rd]1/08]omdtlnmh_]hm]
Vtg_m)]Bghm_-]I;L;]Hmsdqm]Ldc]1/1/]
7-] Nmcdq]F)]Qdyy_]F)]Aqtr_edqqn]R-]B_rd,
e_s_khsx]q_sd]_mc]bg_q_bsdqhrshbr]ne]o_shdmsr]
cxhmf]hm]qdk_shnm]sn]BNUHC,08]hm]Hs_kx-]I;L;]
1/1/]L_qbg]12]’Dota]_gd_c]ne]oqhms(-
8-] Onrsnm]IS)]O_sdk]AJ)]C_uhr];L-]L_m_fd,
ldms]ne]bqhshb_kkx]hkk]_ctksr]vhsg]BNUHC,08-]
I;L;]1/1/]L_qbg]15]’Dota]_gd_c]ne]oqhms(-
0/-]B_n]A)]V_mf]X)]Vdm]C)]ds]_k-];]sqh_k]ne]
knohm_uhqzqhsnm_uhq]hm]_ctksr]gnrohs_khydc]
vhsg]rdudqd]Bnuhc,08-]M]Dmfk]I]Ldc-]CNH9]]
0/-0/45.MDILn_1//0171-
00-]Rgdm]B)]V_mf]Y)]Yg_n]E)]ds]_k-]Sqd_s,
ldms]ne]4]bqhshb_kkx]hkk]o_shdmsr]vhsg]BNU,
HC,08]vhsg]bnmu_kdrbdms]ok_rl_-]I;L;]
1/1/]L_qbg]16]’Dota]_gd_c]ne]oqhms(-
01-]Sntqds]E)]cd]K_la_kkdqhd]W-]Ne]bgknqn,
pthmd]_mc]BNUHC,08-];mshuhq_k]Qdr]1/1/]
02-]A_cdm]KQ)]Qtahm]DI-]Bnuhc,08]–]sgd]
rd_qbg]enq]deedbshud]sgdq_ox-]M]Dmfk]I]Ldc-]
CNH9]]0/-0/45.MDILd1//4366-
03-]cd]Vhs]D)]Edkcl_mm]E)]Bqnmhm]I)]ds]_k-]
Oqnogxk_bshb]_mc]sgdq_odtshb]qdlcdrhuhq]
’FR,4623(]sqd_sldms]hm]sgd]qgdrtr]l_,
b_ptd]lncdk]ne]LDQR,BnU]hmedbshnm-]Oqnb]
M_sk];b_c]Rbh]T]R];]1/1/:]0069]5660,5-
04-]Rgd_g_m]SO)]Rhlr];B)]Fq_g_l]QK)]ds]
_k-]Aqn_c,rodbsqtl]_mshuhq_k]FR,4623]hmgha,
hsr]ansg]dohcdlhb]_mc]ynnmnshb]bnqnm_uh,
qtrdr-]Rbh]Sq_mrk]Ldc]1/06:]8’285(9]d__k2542-
05-]Rgd_g_m]SO)]Rhlr];B)]Kdhrs]RQ)]ds]_k-]
Bnlo_q_shud]sgdq_odtshb]deehb_bx]ne]qdl,
cdrhuhq]_mc]bnlahm_shnm]knohm_uhq)]qhsnm_,
uhq)]_mc]hmsdqedqnm]ads_]_f_hmrs]LDQR,
BnU-]M_s]Bnlltm]1/1/:]009]111-
06-]V_mf]L)]B_n]Q)]Yg_mf]K)]ds]_k-]Qdlcd,
rhuhq]_mc]bgknqnpthmd]deedbshudkx]hmghahs]sgd]
qdbdmskx]dldqfdc]mnudk]bnqnm_uhqtr]’1/08,
mBnU(]hm]uhsqn-]Bdkk]Qdr]1/1/:]2/9]158,60-
07-]Ltk_mft]R)]Cncc]KD)]C_udx]QS]Iq)]ds]
_k-];]q_mcnlhydc)]bnmsqnkkdc]sqh_k]ne]Dan,
k_]uhqtr]chrd_rd]sgdq_odtshbr-]M]Dmfk]I]
Ldc]1/08:]2709]1182,2/2-
08-]Dtqnod_m] Ldchbhmdr] ;fdmbx-] Rtl,
l_qx]nm]bnlo_rrhnm_sd]trd9]]Qdlcdrhuhq]
Fhkd_c-];oqhk]2)]1/1/]’gssor9..vvv]-dl_]
-dtqno_]-dt.]dm.]cnbtldmsr.]nsgdq.]rtll_qx]
,]bnlo_rrhnm_sd],]trd],]qdlcdrhuhq],]fhkd_c dm]
-oce(-
1/-]Jti_vrjh]R;)]Vnmf]JJ)]Bnkkhmr]IO)]ds]
_k-]Ehqrs]01]o_shdmsr]vhsg]bnqnm_uhqtr]chr,
d_rd] 1/08] ’BNUHC,08(] hm] sgd] Tmhsdc]
Rs_sdr-]ldcQwhu)]L_qbg]01)]1/1/]’gssor9..
vvv]-ldcqwhu]-nqf.]bnmsdms.]0/]-00/0.]1/1/]
-/2]-/8]-1//21785u0(-
10-]Gnkrgtd]LK)]CdAnks]B)]Khmcpthrs]R)]ds]
_k-]Ehqrs]b_rd]ne]1/08]mnudk]bnqnm_uhqtr]hm]
sgd]Tmhsdc]Rs_sdr-]M]Dmfk]I]Ldc]1/1/:]2719]
818,25-
11-]Kdrbtqd]EW)]Ant_cl_]K)]Mftxdm]C)]ds]
_k-]Bkhmhb_k]_mc]uhqnknfhb_k]c_s_]ne]sgd]
ehqrs]b_rdr]ne]BNUHC,08]hm]Dtqnod9]_]b_rd]
rdqhdr-]K_mbds]Hmedbs]Chr]1/1/]L_qbg]16]
’Dota]_gd_c]ne]oqhms(-
12-];qdmsy]L)]Xhl]D)]Jk_ee]K)]ds]_k-]Bg_q,
_bsdqhrshbr]_mc]ntsbnldr]ne]10]bqhshb_kkx]hkk]
o_shdmsr]vhsg]BNUHC,08]hm]V_rghmfsnm]
Rs_sd-]I;L;]1/1/]L_qbg]08]’Dota]_gd_c]
ne]oqhms(-
13-]V_mf]C)]Gt]A)]Gt]B)]ds]_k-]Bkhmhb_k]
bg_q_bsdqhrshbr]ne]027]gnrohs_khydc]o_,
shdmsr]vhsg]1/08]mnudk]bnqnm_uhqtr,hmedbs,
dc]omdtlnmh_]hm]Vtg_m)]Bghm_-]I;L;]
1/1/]Edaqt_qx]6]’Dota]_gd_c]ne]oqhms(-
14-]Vt]Y)]LbFnnf_m]IL-]Bg_q_bsdqhrshbr]
ne]_mc]hlonqs_ms]kdrrnmr]eqnl]sgd]bnqnm_,
uhqtr]chrd_rd]1/08]’BNUHC,08(]ntsaqd_j]hm]
Bghm_9]rtll_qx]ne]_]qdonqs]ne]61]203]
b_rdr]eqnl]sgd]Bghmdrd]Bdmsdq]enq]Chrd_rd]
Bnmsqnk]_mc]Oqdudmshnm-]I;L;]1/1/]Eda,
qt_qx]13]’Dota]_gd_c]ne]oqhms(-
15-]Ygnt]E)]Xt]S)]Ct]Q)]ds]_k-]Bkhmhb_k]
bntqrd]_mc]qhrj]e_bsnqr]enq]lnqs_khsx]ne]
_ctks]hmo_shdmsr]vhsg]BNUHC,08]hm]Vt,
g_m)]Bghm_9]_]qdsqnrodbshud]bngnqs]rstcx-]
K_mbds]1/1/:]2849]0/43,51-
16-]Ag_sq_it]OJ)]Fg_rrdlhdg]AI)]Mhbgnkr]
L)]ds]_k-]Bnuhc,08]hm]bqhshb_kkx]hkk]o_shdmsr]hm]
sgd]Rd_sskd]qdfhnm]–]b_rd]rdqhdr-]M]Dmfk]I]
Ldc-]CNH9]]0/-0/45.MDILn_1//34//-
17-]HBM;QB]qdonqs]nm]BNUHC,08]hm]bqhsh,
b_k]b_qd-]Knmcnm9]]Hmsdmrhud]B_qd]M_shnm_k]
;tchs]%]Qdrd_qbg]Bdmsqd)]L_qbg]16)]1/1/]
’gssor9..vvv]-hbm_qb]-nqf.]C_s_Rdquhbdr]
.];ss_bgldmsr.]Cnvmkn_c.]a4e48474],]476/]
],]d_00],]8013],]//4/45/0/78a(-
18-]Yg_mf]B)]Rgh]K)]V_mf]ER-]Khudq]hmitqx]
hm]BNUHC,089]l_m_fdldms]_mc]bg_kkdmf,
dr-]K_mbds]F_rsqndmsdqnk]Gdo_snk]1/1/]
Anov phfgsSyS0.0.SD rr bgtrdssrSDdchb iSRnbhdsv )

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